{"id":"https://openalex.org/W2313386262","doi":"https://doi.org/10.1089/aid.1.1986.2.51","title":"HTLV-III/LAV ANTIBODIES AND VIRUS IN HEMOPHILIA PATIENTS IN NEBRASKA: SURVEY AND INITIATION OF A PROSPECTIVE STUDY","display_name":"HTLV-III/LAV ANTIBODIES AND VIRUS IN HEMOPHILIA PATIENTS IN NEBRASKA: SURVEY AND INITIATION OF A PROSPECTIVE STUDY","publication_year":1986,"publication_date":"1986-02-01","ids":{"openalex":"https://openalex.org/W2313386262","doi":"https://doi.org/10.1089/aid.1.1986.2.51","mag":"2313386262","pmid":"https://pubmed.ncbi.nlm.nih.gov/2424467"},"language":"en","primary_location":{"id":"doi:10.1089/aid.1.1986.2.51","doi":"https://doi.org/10.1089/aid.1.1986.2.51","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1.1986.2.51","pdf_url":null,"source":{"id":"https://openalex.org/S4210220745","display_name":"Aids Research","issn_l":"0737-6006","issn":["0737-6006","2332-4112"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046772826","display_name":"David J. Volsky","orcid":"https://orcid.org/0000-0001-6788-1752","observed_orcids":["https://orcid.org/0000-0001-6788-1752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Volsky","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100845738","display_name":"Yintang Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yin-Tang Wu","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000190434","display_name":"Faruk Sinangil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faruk Sinangil","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064976025","display_name":"Jonathan C. Goldsmith","orcid":"https://orcid.org/0000-0002-9907-9526","observed_orcids":["https://orcid.org/0000-0002-9907-9526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan C. Goldsmith","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2494,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61466039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":"51","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.06350000202655792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-iii","display_name":"HTLV-III","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hiv-antibodies","display_name":"HIV antibodies","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hemophilia","display_name":"hemophilia","score":0.824999988079071},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9660000205039978},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.39800000190734863},{"id":"https://openalex.org/keywords/antibody-titers","display_name":"antibody titers","score":0.718999981880188},{"id":"https://openalex.org/keywords/blood-product-transfusion","display_name":"blood product transfusion","score":0.5320000052452087},{"id":"https://openalex.org/keywords/factor-viii-concentrate","display_name":"factor VIII concentrate","score":0.8230000138282776},{"id":"https://openalex.org/keywords/factor-ix-concentrate","display_name":"factor IX concentrate","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778258694","wikidata":"https://www.wikidata.org/wiki/Q1923157","display_name":"Cryoprecipitate","level":3,"score":0.7720409035682678},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.68888920545578},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6778604388237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.642615795135498},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.6037803292274475},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5874312520027161},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5312331318855286},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5003862380981445},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49985265731811523},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4339510202407837},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009329","descriptor_name":"Nebraska","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017977","descriptor_name":"Deltaretrovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017977","descriptor_name":"Deltaretrovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/aid.1.1986.2.51","doi":"https://doi.org/10.1089/aid.1.1986.2.51","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.1.1986.2.51","pdf_url":null,"source":{"id":"https://openalex.org/S4210220745","display_name":"Aids Research","issn_l":"0737-6006","issn":["0737-6006","2332-4112"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research","raw_type":"journal-article"},{"id":"pmid:2424467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2424467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1133164194","display_name":null,"funder_award_id":"CA 37465","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6104308252","display_name":null,"funder_award_id":"190001-11","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1968873679","https://openalex.org/W1977282539","https://openalex.org/W1997685222","https://openalex.org/W1999381784","https://openalex.org/W2003721666","https://openalex.org/W2013357966","https://openalex.org/W2014317403","https://openalex.org/W2016534065","https://openalex.org/W2042695720","https://openalex.org/W2064272987","https://openalex.org/W2091565871","https://openalex.org/W2137267461","https://openalex.org/W2161420098","https://openalex.org/W2418577758"],"related_works":["https://openalex.org/W2086555891","https://openalex.org/W2082677930","https://openalex.org/W155078154","https://openalex.org/W2437280427","https://openalex.org/W2274280482","https://openalex.org/W2075631901","https://openalex.org/W2018258966","https://openalex.org/W203094308","https://openalex.org/W2221783022","https://openalex.org/W2044729844"],"abstract_inverted_index":{"Thirty-nine":[0],"patients":[1,36,81,120,182,194],"from":[2,148],"the":[3,11,27,77,119,164,169,175,181,199],"Nebraska":[4],"Regional":[5],"Hemophilia":[6],"Center":[7],"were":[8,40,83],"studied":[9],"for":[10,20,42],"prevalence":[12],"and":[13,19,49,69,111],"titers":[14,141],"of":[15,23,33,58,61,118,137,142,168,180,193],"antibodies":[16,44,144],"to":[17,145,150,172,198,203],"HTLV-III/LAV,":[18],"clinical":[21],"symptoms":[22],"possible":[24,170],"progression":[25],"toward":[26],"acquired":[28],"immunodeficiency":[29],"syndrome":[30],"(AIDS).":[31],"Fourteen":[32],"26":[34],"(54%)":[35],"with":[37,72,123,163],"hemophilia":[38],"A":[39],"positive":[41],"HTLV-III/LAV":[43,74,133,146,158,173],"as":[45],"determined":[46],"by":[47,65],"immunofluorescence":[48],"Western":[50],"blotting.":[51],"Retrovirus":[52],"was":[53],"detected":[54],"in":[55,183],"cultured":[56],"lymphocytes":[57],"two":[59,100,112],"out":[60],"three":[62],"seropositive":[63,139],"individuals":[64],"reverse":[66],"transcriptase":[67],"assay":[68],"molecular":[70],"hybridization":[71],"cloned":[73],"probe.":[75],"Of":[76],"twelve":[78],"factor":[79,90,124],"VIII-deficient":[80],"who":[82],"seronegative,":[84],"one":[85,104],"had":[86,105,113,132,186],"received":[87],"only":[88,94,122],"heat-treated":[89],"VIII":[91],"concentrates,":[92,103,126],"six":[93],"cryoprecipitate":[95,131],"or":[96,130,189],"fresh":[97],"frozen":[98],"plasma,":[99,129],"prothrombin":[101],"complex":[102],"not":[106,190],"been":[107,115],"transfused":[108],"since":[109],"1983,":[110],"never":[114],"transfused.":[116],"None":[117],"treated":[121],"IX":[125],"volunteer":[127],"donor":[128],"antibodies.":[134],"In":[135,166],"12":[136],"14":[138],"hemophiliacs,":[140],"serum":[143],"ranged":[147],"1:1,280":[149],"1:10,240,":[151],"indicating":[152],"a":[153],"strong":[154],"immune":[155],"response":[156],"against":[157],"antigens":[159],"and/or":[160],"persistent":[161],"infection":[162],"virus.":[165],"spite":[167],"exposure":[171],"during":[174],"past":[176],"four":[177],"years,":[178],"none":[179],"this":[184,191],"group":[185,192],"AIDS.":[187],"Whether":[188],"has":[195],"developed":[196],"immunity":[197],"AIDS":[200],"retrovirus":[201],"remains":[202],"be":[204],"determined.":[205]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}