{"id":"https://openalex.org/W23133455","doi":null,"title":"Measurement of megakaryocyte frequency and ploidy distribution in unfractionated murine bone marrow.","display_name":"Measurement of megakaryocyte frequency and ploidy distribution in unfractionated murine bone marrow.","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W23133455","mag":"23133455","pmid":"https://pubmed.ncbi.nlm.nih.gov/2465169"},"language":"en","primary_location":{"id":"pmid:2465169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2465169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051775780","display_name":"Laurence Corash","orcid":"https://orcid.org/0000-0002-8615-9869","observed_orcids":["https://orcid.org/0000-0002-8615-9869"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Corash","raw_affiliation_strings":["Department of Laboratory Medicine, University of California School of Medicine, San Francisco 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California School of Medicine, San Francisco 94143","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111405610","display_name":"J Levin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Levin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001332643","display_name":"Y Mok","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Mok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G Baker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112062623","display_name":"James R. McDowell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J McDowell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0259,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91006007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"278","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/megakaryocyte-ploidy","display_name":"megakaryocyte ploidy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.6029999852180481},{"id":"https://openalex.org/keywords/murine-bone-marrow","display_name":"murine bone marrow","score":0.7250000238418579},{"id":"https://openalex.org/keywords/megakaryocyte-maturation","display_name":"megakaryocyte maturation","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.9643106460571289},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7818061709403992},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6308687925338745},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.559982419013977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521307647228241},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.4675883948802948},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.41388750076293945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35085850954055786},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32267582416534424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2999994456768036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19872498512268066},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.16601860523223877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15583714842796326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13045892119407654},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11319035291671753},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09158524870872498},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.07924088835716248},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2465169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2465169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"mag:23133455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2465169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W23689343","https://openalex.org/W63864630","https://openalex.org/W121389000","https://openalex.org/W185941675","https://openalex.org/W1274671738","https://openalex.org/W1808018531","https://openalex.org/W1820832512","https://openalex.org/W1852416791","https://openalex.org/W2127689078","https://openalex.org/W2145481747","https://openalex.org/W2160882187","https://openalex.org/W2221264044","https://openalex.org/W2345087846","https://openalex.org/W2396552409","https://openalex.org/W2400605378","https://openalex.org/W2417963520","https://openalex.org/W2434483345"],"related_works":["https://openalex.org/W2351437716","https://openalex.org/W277604187","https://openalex.org/W1706129219","https://openalex.org/W1998357553","https://openalex.org/W2398306539","https://openalex.org/W10405645","https://openalex.org/W2344076026","https://openalex.org/W2164978496","https://openalex.org/W2124306898","https://openalex.org/W2118385042"],"abstract_inverted_index":{"Measurement":[0],"of":[1,16,158,164,185,205,214,221,236],"megakaryocyte":[2,40,75,114,142,161,166,237],"frequency,":[3],"ploidy":[4,143,148,187,207,240],"distribution,":[5],"and":[6,71,134,151,155,231,239],"maturation":[7],"stage":[8],"have":[9,34,43],"been":[10],"complicated":[11],"by":[12],"the":[13,140,159,165,177,215],"low":[14],"frequency":[15,115,238],"megakaryocytes":[17,54],"in":[18,50,55],"either":[19],"bone":[20,58,95,224,229],"marrow":[21,59,225,230],"or":[22,39],"spleen.":[23],"Due":[24],"to":[25,52,72,170],"harsh":[26],"labeling":[27],"conditions,":[28,86],"previous":[29],"studies":[30],"utilizing":[31],"flow":[32],"cytometry":[33],"not":[35],"quantified":[36],"cell":[37,63,89,171],"recovery":[38,90,220],"frequency.":[41],"We":[42],"modified":[44,136],"our":[45,125,135],"two-color":[46,216],"fluorescence-activated":[47],"cytometric":[48],"technique":[49,129,217],"order":[51],"identify":[53],"unfractionated":[56,92,228],"murine":[57,94],"with":[60,78,106,130,168,196],"a":[61],"fluoresceinated":[62],"surface":[64,172],"immunologic":[65],"probe":[66],"(heterologous":[67],"polyclonal":[68],"platelet":[69],"antiserum)":[70],"selectively":[73],"measure":[74],"DNA":[76,110],"content":[77],"propidium":[79],"iodide":[80],"using":[81],"isosmolar":[82],"conditions.":[83],"Under":[84],"these":[85],"total":[87,160,222],"nucleated":[88,223],"from":[91,227],"normal":[93],"marrow,":[96],"after":[97],"all":[98],"preparative":[99],"procedures,":[100],"averaged":[101],"68.0%":[102],"+/-":[103,108,121],"5.0%":[104],"(SD)":[105],"93.5%":[107],"2.0%":[109],"staining":[111],"efficiency.":[112],"Mean":[113],"(n":[116],"=":[117],"30)":[118],"was":[119,145],"0.14%":[120],"0.04%.":[122],"Using":[123],"both":[124],"previously":[126,242],"described":[127],"gating":[128],"single":[131],"parameter":[132,138],"analysis":[133],"dual":[137],"technique,":[139],"modal":[141],"class":[144,188],"16N.":[146],"Low":[147],"megakaryocytes,":[149],"2N":[150],"4N,":[152],"constituted":[153],"9.8%":[154],"10.8%,":[156],"respectively,":[157],"population.":[162],"Analysis":[163],"population":[167,180],"respect":[169],"fluorescence":[173],"intensity":[174],"demonstrated":[175],"that":[176],"dimly":[178],"fluorescent":[179,198],"contained":[181,201],"an":[182,202],"increased":[183,203],"proportion":[184,204],"lower":[186],"cells":[189,208,226],"(2N":[190],"+":[191,193,210],"4N":[192],"8N)":[194],"compared":[195],"brightly":[197],"cells,":[199],"which":[200],"higher":[206],"(16N":[209],"32N).":[211],"Our":[212],"modifications":[213],"yielded":[218],"improved":[219],"provided":[232],"more":[233],"precise":[234],"measurements":[235],"than":[241],"available.":[243]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
