{"id":"https://openalex.org/W2313185080","doi":"https://doi.org/10.1097/shk.0000000000000603","title":"Cellular Stress Responses and Monitored Cellular Activities","display_name":"Cellular Stress Responses and Monitored Cellular Activities","publication_year":2016,"publication_date":"2016-03-08","ids":{"openalex":"https://openalex.org/W2313185080","doi":"https://doi.org/10.1097/shk.0000000000000603","mag":"2313185080","pmid":"https://pubmed.ncbi.nlm.nih.gov/26954943"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0000000000000603","doi":"https://doi.org/10.1097/shk.0000000000000603","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000603","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031601538","display_name":"Teiji Sawa","orcid":"https://orcid.org/0000-0001-9558-9011","observed_orcids":["https://orcid.org/0000-0001-9558-9011"]},"institutions":[{"id":"https://openalex.org/I205924995","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I1319490839","https://openalex.org/I205924995"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210128784","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210128784"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Teiji Sawa","raw_affiliation_strings":["Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","Address reprint requests to Teiji Sawa, MD, PhD, 465 Kajii-cho, Kamigyo, Kyoto 602-8566, Japan. E-mail: [email\u00a0protected]","TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Address reprint requests to Teiji Sawa, MD, PhD, 465 Kajii-cho, Kamigyo, Kyoto 602-8566, Japan. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan","institution_ids":["https://openalex.org/I205924995","https://openalex.org/I4210128784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101006725","display_name":"Yoshifumi Naito","orcid":"https://orcid.org/0009-0004-4336-7723","observed_orcids":["https://orcid.org/0009-0004-4336-7723"]},"institutions":[{"id":"https://openalex.org/I205924995","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I1319490839","https://openalex.org/I205924995"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210128784","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210128784"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Yoshifumi Naito","raw_affiliation_strings":["Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan","institution_ids":["https://openalex.org/I205924995","https://openalex.org/I4210128784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080819101","display_name":"Hideya Kato","orcid":"https://orcid.org/0000-0001-5197-6829","observed_orcids":["https://orcid.org/0000-0001-5197-6829"]},"institutions":[{"id":"https://openalex.org/I205924995","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I1319490839","https://openalex.org/I205924995"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210128784","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210128784"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Hideya Kato","raw_affiliation_strings":["Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan","institution_ids":["https://openalex.org/I205924995","https://openalex.org/I4210128784"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043528593","display_name":"Fumimasa Amaya","orcid":"https://orcid.org/0000-0003-2934-0845","observed_orcids":["https://orcid.org/0000-0003-2934-0845"]},"institutions":[{"id":"https://openalex.org/I205924995","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I1319490839","https://openalex.org/I205924995"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210128784","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210128784"]}],"countries":["GB","JP"],"is_corresponding":false,"raw_author_name":"Fumimasa Amaya","raw_affiliation_strings":["Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"TS and FA are currently receiving grants from Grant-in-Aid for Scientific Research (Kakenhi Nos. 24390403, 10206013, 15H05008 to TS, and J152004025 to FA), Japan Society for the Promotion of Science, Japan","institution_ids":["https://openalex.org/I205924995","https://openalex.org/I4210128784"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0594,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.02919538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"46","issue":"2","first_page":"113","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4221000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4221000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.2199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.0885000005364418,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.7450000047683716},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9089999794960022},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/xenobiotic-detoxification","display_name":"xenobiotic detoxification","score":0.8450000286102295},{"id":"https://openalex.org/keywords/proteobacteria","display_name":"Proteobacteria","score":0.5839999914169312},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9539999961853027},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.746999979019165},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.9160000085830688},{"id":"https://openalex.org/keywords/inflammatory-syndrome","display_name":"inflammatory syndrome","score":0.8130000233650208},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6006276607513428},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5428422093391418},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.5015175342559814},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5002987384796143},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.4532396197319031},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4191015362739563},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4105187952518463},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37223130464553833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2893819212913513},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.2777751684188843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18561306595802307},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1338416039943695},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.13137778639793396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10946694016456604},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/shk.0000000000000603","doi":"https://doi.org/10.1097/shk.0000000000000603","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000603","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:26954943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26954943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1229821466","display_name":"Inflammasome mediated neuroinflammation as a novel target of chronic pain","funder_award_id":"15H04969","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G577036740","display_name":"The mechanism on ventilator induced kidney injury associated with kidney-lung crosstalk","funder_award_id":"24390404","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7619471293","display_name":"Therapeutic possibility of MANF, a new class of nerve growth factor, against neuropathic pain.","funder_award_id":"26670692","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W22461457","https://openalex.org/W115356933","https://openalex.org/W1515041923","https://openalex.org/W1521381364","https://openalex.org/W1523213544","https://openalex.org/W1534687091","https://openalex.org/W1647075334","https://openalex.org/W1883244306","https://openalex.org/W1964115194","https://openalex.org/W1965021143","https://openalex.org/W1974522038","https://openalex.org/W1979017842","https://openalex.org/W1984672460","https://openalex.org/W1989700964","https://openalex.org/W1996488304","https://openalex.org/W2005036344","https://openalex.org/W2007389227","https://openalex.org/W2009527638","https://openalex.org/W2011007912","https://openalex.org/W2019492856","https://openalex.org/W2023542615","https://openalex.org/W2026932718","https://openalex.org/W2027969289","https://openalex.org/W2033448006","https://openalex.org/W2038324706","https://openalex.org/W2038481472","https://openalex.org/W2042705631","https://openalex.org/W2046818883","https://openalex.org/W2049506893","https://openalex.org/W2053095874","https://openalex.org/W2055571966","https://openalex.org/W2057585285","https://openalex.org/W2058373529","https://openalex.org/W2064966129","https://openalex.org/W2068141342","https://openalex.org/W2077930526","https://openalex.org/W2080287136","https://openalex.org/W2081422975","https://openalex.org/W2084034472","https://openalex.org/W2086671458","https://openalex.org/W2087186922","https://openalex.org/W2093579074","https://openalex.org/W2098356981","https://openalex.org/W2104818214","https://openalex.org/W2107513655","https://openalex.org/W2109491705","https://openalex.org/W2112068811","https://openalex.org/W2112655328","https://openalex.org/W2116379047","https://openalex.org/W2117611012","https://openalex.org/W2117723317","https://openalex.org/W2117999670","https://openalex.org/W2118580783","https://openalex.org/W2125382661","https://openalex.org/W2134219545","https://openalex.org/W2137173138","https://openalex.org/W2139776848","https://openalex.org/W2141370830","https://openalex.org/W2149723200","https://openalex.org/W2150594596","https://openalex.org/W2153751762","https://openalex.org/W2161802000","https://openalex.org/W2165288651","https://openalex.org/W2171154574","https://openalex.org/W2171740941","https://openalex.org/W2205080227","https://openalex.org/W2266355581","https://openalex.org/W2462855682","https://openalex.org/W2615749116","https://openalex.org/W2745410698","https://openalex.org/W4231306940","https://openalex.org/W4254804607"],"related_works":["https://openalex.org/W3030792024","https://openalex.org/W2038414489","https://openalex.org/W2530253449","https://openalex.org/W4312196449","https://openalex.org/W2894565780","https://openalex.org/W4231221631","https://openalex.org/W3009610935","https://openalex.org/W7067509500","https://openalex.org/W4404637136","https://openalex.org/W2167049000"],"abstract_inverted_index":{"To":[0],"survive,":[1],"organisms":[2],"require":[3],"mechanisms":[4,42],"that":[5,63,72,79],"enable":[6],"them":[7],"to":[8,34,44,46,88,171,201],"sense":[9],"changes":[10],"in":[11,96,105,173,231],"the":[12,31,41,55,97,154,178,182,195,225,232],"outside":[13,56],"environment,":[14],"introduce":[15],"necessary":[16],"responses,":[17],"and":[18,40,78,117,126,142,149,152,160,192,210],"resist":[19],"unfavorable":[20],"distortion.":[21],"Consequently,":[22],"through":[23],"evolutionary":[24],"adaptation,":[25],"cells":[26,65],"have":[27,101],"become":[28],"equipped":[29,67],"with":[30,68,168],"apparatus":[32],"required":[33],"monitor":[35],"their":[36,74],"fundamental":[37,75],"intracellular":[38,99],"processes":[39],"needed":[43],"try":[45],"offset":[47],"malfunction":[48],"without":[49],"receiving":[50],"any":[51],"direct":[52],"signals":[53],"from":[54],"environment.":[57],"It":[58],"has":[59],"been":[60,102],"shown":[61],"recently":[62],"eukaryotic":[64],"are":[66],"a":[69,221],"special":[70],"mechanism":[71,87],"monitors":[73],"cellular":[76,93,130,136,169,208],"functions":[77],"some":[80],"pathogenic":[81],"proteobacteria":[82],"can":[83,217],"override":[84],"this":[85],"monitoring":[86],"cause":[89],"harm.":[90],"The":[91,162],"monitored":[92,207],"activities":[94,116,137,209],"involved":[95],"stressed":[98],"response":[100],"researched":[103],"extensively":[104],"Caenorhabditis":[106],"elegans,":[107],"where":[108],"discovery":[109],"of":[110,184,197,227],"an":[111],"association":[112],"between":[113],"key":[114],"mitochondrial":[115,140,198,215],"innate":[118],"immune":[119],"responses":[120,170],"was":[121],"named":[122],"\"cellular":[123],"associated":[124,167],"detoxification":[125],"defenses":[127],"(cSADD).\"":[128],"This":[129],"surveillance":[131],"pathway":[132,164],"(cSADD)":[133],"oversees":[134],"core":[135],"such":[138],"as":[139],"respiration":[141,199],"protein":[143],"transport":[144],"into":[145],"mitochondria,":[146],"detects":[147],"xenobiotics":[148],"invading":[150],"pathogens,":[151],"activates":[153],"endocrine":[155],"pathways":[156],"controlling":[157],"behavior,":[158],"detoxification,":[159],"immunity.":[161],"cSADD":[163],"is":[165],"probably":[166,218],"stress":[172],"human":[174],"inflammatory":[175,186,229],"diseases.":[176],"In":[177],"critical":[179,233],"care":[180,234],"field,":[181],"pathogenesis":[183,226],"lethal":[185,228],"syndromes":[187,191,230],"(e.g.,":[188],"respiratory":[189],"distress":[190],"sepsis)":[193],"involves":[194],"disturbance":[196],"leading":[200],"cell":[202],"death.":[203],"Up-to-date":[204],"knowledge":[205,222],"about":[206],"cSADD,":[211],"especially":[212],"focusing":[213],"on":[214],"involvement,":[216],"help":[219],"fill":[220],"gap":[223],"regarding":[224],"field.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}