{"id":"https://openalex.org/W2313147407","doi":"https://doi.org/10.1136/heartjnl-2014-306118.196","title":"196 Tsg-6: A Novel Regulator Of VSMC Differentiation and Calcification?","display_name":"196 Tsg-6: A Novel Regulator Of VSMC Differentiation and Calcification?","publication_year":2014,"publication_date":"2014-05-31","ids":{"openalex":"https://openalex.org/W2313147407","doi":"https://doi.org/10.1136/heartjnl-2014-306118.196","mag":"2313147407"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2014-306118.196","doi":"https://doi.org/10.1136/heartjnl-2014-306118.196","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2014-306118.196","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077395189","display_name":"Rebecca F. Taylor","orcid":"https://orcid.org/0000-0003-4033-3793","observed_orcids":["https://orcid.org/0000-0003-4033-3793"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Taylor","raw_affiliation_strings":["University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006588214","display_name":"Anthony J. Day","orcid":"https://orcid.org/0000-0002-1415-3134","observed_orcids":["https://orcid.org/0000-0002-1415-3134"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony Day","raw_affiliation_strings":["University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052276045","display_name":"Ann E. Canfield","orcid":"https://orcid.org/0000-0002-8983-5674","observed_orcids":["https://orcid.org/0000-0002-8983-5674"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ann Canfield","raw_affiliation_strings":["University of Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22587456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"Suppl 3","first_page":"A108.2","last_page":"A108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.5307999849319458,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.260699987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tsg-6","display_name":"TSG-6","score":0.9769999980926514},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/beta-glycerophosphate","display_name":"beta-glycerophosphate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.8259999752044678},{"id":"https://openalex.org/keywords/msx2","display_name":"Msx2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.8499413728713989},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.8462271690368652},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.7710710167884827},{"id":"https://openalex.org/C2781122658","wikidata":"https://www.wikidata.org/wiki/Q24744812","display_name":"Calponin","level":3,"score":0.7005050182342529},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.6847912073135376},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5783342123031616},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5316163897514343},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4986228942871094},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.45986035466194153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44233840703964233},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.41158634424209595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35992181301116943},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3479418456554413},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33885592222213745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30441412329673767},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.20471692085266113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12900736927986145},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.12366202473640442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10663524270057678}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/heartjnl-2014-306118.196","doi":"https://doi.org/10.1136/heartjnl-2014-306118.196","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2014-306118.196","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:heartjnl:100/Suppl_3/A108-b","doi":null,"is_oa":false,"landing_page_url":"http://heart.bmj.com/cgi/content/short/100/Suppl_3/A108-b","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2765574605","https://openalex.org/W2316811686","https://openalex.org/W7171577166","https://openalex.org/W2415229948","https://openalex.org/W3197253632","https://openalex.org/W2074974255","https://openalex.org/W1973030849","https://openalex.org/W3029276492","https://openalex.org/W2937565719","https://openalex.org/W2167105570"],"abstract_inverted_index":{"Vascular":[0],"calcification":[1],"is":[2,14,36,107,205,230],"the":[3,9,28,45,84,115,195,234],"formation":[4,49],"of":[5,19,27,47,86,95,118,142,157,173,209,220,240],"bone-like":[6],"structures":[7],"in":[8,44,122,161,232],"vessel":[10],"wall.":[11],"The":[12],"pathology":[13],"characterised":[15],"by":[16,74,83,102,171,197],"osteogenic":[17,87,154,218],"differentiation":[18,80,219],"vascular":[20,57,210],"smooth":[21,96,166],"muscle":[22,97,167,177],"cells":[23],"(VSMCs)":[24],"and":[25,50,91,93,131,138,152,183,187,217],"mineralisation":[26,147,216],"extracellular":[29],"matrix.":[30],"Tumour":[31],"necrosis":[32],"factor-stimulated":[33],"gene-6":[34],"(TSG-6)":[35],"an":[37],"inflammation-associated":[38],"protein":[39],"that":[40,226],"has":[41],"been":[42],"implicated":[43],"inhibition":[46],"bone":[48],"thus,":[51],"we":[52],"hypothesised,":[53],"may":[54],"also":[55,224],"influence":[56],"calcification.":[58],"Confluent":[59],"VSMCs":[60,162],"were":[61],"cultured":[62],"with":[63,76],"3":[64],"mM":[65],"beta-glycerophosphate":[66],"(BGP)":[67],"to":[68,124,193],"induce":[69],"mineralisation.":[70],"Calcification":[71],"was":[72,81,127],"confirmed":[73,135],"staining":[75],"alizarin":[77],"red.":[78],"Osteogenic":[79],"demonstrated":[82],"up-regulation":[85,172],"markers":[88,99,175],"(e.g.":[89,100],"Runx2":[90],"Msx2)":[92],"down-regulation":[94],"cell":[98],"aSMA)":[101],"qPCR.":[103],"TSG-6":[104,126,143,159,204,228,242],"mRNA":[105],"expression":[106,133,144,160,229],"significantly":[108,145],"up-regulated":[109],"(6-fold,":[110],"p":[111,149],"<":[112,150],"0.0005)":[113],"during":[114],"early":[116],"stages":[117],"BGP-induced":[119],"VSMC":[120,235,247],"mineralisation,":[121],"comparison":[123],"control.":[125],"knocked-down":[128],"using":[129,136,185],"siRNA":[130],"reduced":[132],"(>86%)":[134],"qPCR":[137,186],"western":[139,188],"blotting.":[140,189],"Loss":[141],"increased":[146],"(1.6-fold,":[148],"0.001)":[151],"accelerated":[153],"differentiation.":[155],"Knock-down":[156],"basal":[158,227,241],"promoted":[163],"a":[164,206,244],"mature":[165],"phenotype,":[168],"as":[169,238],"shown":[170],"contractile":[174,246],"(smooth":[176],"myosin":[178],"heavy":[179],"chain,":[180],"aSMA,":[181],"SM22a":[182],"calponin)":[184],"On-going":[190],"studies":[191],"aim":[192],"determine":[194],"mechanism":[196],"which":[198,212],"these":[199],"effects":[200],"occur.":[201],"In":[202],"conclusion,":[203],"novel":[207],"regulator":[208],"calcification,":[211],"can":[213],"modulate":[214],"both":[215],"VSMCs.":[221],"Our":[222],"data":[223],"suggest":[225],"crucial":[231],"maintaining":[233],"synthetic":[236],"state,":[237],"loss":[239],"promotes":[243],"mature,":[245],"phenotype.":[248]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}
