{"id":"https://openalex.org/W2312965612","doi":"https://doi.org/10.1152/ajpcell.1998.274.4.c914","title":"Sulfhydryls associated with H2O2-induced channel activation are on luminal side of ryanodine receptors","display_name":"Sulfhydryls associated with H2O2-induced channel activation are on luminal side of ryanodine receptors","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2312965612","doi":"https://doi.org/10.1152/ajpcell.1998.274.4.c914","mag":"2312965612","pmid":"https://pubmed.ncbi.nlm.nih.gov/9575787"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1998.274.4.c914","doi":"https://doi.org/10.1152/ajpcell.1998.274.4.c914","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1998.274.4.c914","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111799738","display_name":"Toshiharu \u00d4ba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiharu Oba","raw_affiliation_strings":["Departments of Physiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007492003","display_name":"Tatsuya Ishikawa","orcid":"https://orcid.org/0000-0003-3553-6510","observed_orcids":["https://orcid.org/0000-0003-3553-6510"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Ishikawa","raw_affiliation_strings":["Pediatrics, Nagoya City University Medical School, Mizuho-ku, Nagoya 467, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Nagoya City University Medical School, Mizuho-ku, Nagoya 467, Japan; and","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108287557","display_name":"Mamoru Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mamoru Yamaguchi","raw_affiliation_strings":["Department of Veterinary Bioscience, Ohio State University, Columbus, Ohio 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Bioscience, Ohio State University, Columbus, Ohio 43210","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4229,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.8951467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"274","issue":"4","first_page":"C914","last_page":"C921"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.7289999723434448},{"id":"https://openalex.org/keywords/calcium-release-channel","display_name":"calcium release channel","score":0.6159999966621399},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7390000224113464},{"id":"https://openalex.org/keywords/channel-activation","display_name":"channel activation","score":0.5239999890327454},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.5400000214576721},{"id":"https://openalex.org/keywords/p-chloromercuriphenylsulfonic-acid","display_name":"p-chloromercuriphenylsulfonic acid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.6000000238418579},{"id":"https://openalex.org/keywords/caffeine-contracture","display_name":"caffeine contracture","score":0.5440000295639038},{"id":"https://openalex.org/keywords/skinned-muscle-fibers","display_name":"skinned muscle fibers","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.8113730549812317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6952725648880005},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.6130499243736267},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5190242528915405},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46933192014694214},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45166897773742676},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3324640691280365},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2997509837150574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26060187816619873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12729761004447937},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12349852919578552}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001001","descriptor_name":"Anura","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002731","descriptor_name":"4-Chloromercuribenzenesulfonate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013439","descriptor_name":"Sulfhydryl Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1998.274.4.c914","doi":"https://doi.org/10.1152/ajpcell.1998.274.4.c914","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1998.274.4.c914","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:9575787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9575787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1495748721","https://openalex.org/W1496902535","https://openalex.org/W1556814137","https://openalex.org/W1596238171","https://openalex.org/W1852969178","https://openalex.org/W1970727439","https://openalex.org/W1979996866","https://openalex.org/W2019385148","https://openalex.org/W2020392997","https://openalex.org/W2033648099","https://openalex.org/W2039547987","https://openalex.org/W2039804727","https://openalex.org/W2053264179","https://openalex.org/W2055730756","https://openalex.org/W2075506960","https://openalex.org/W2076408588","https://openalex.org/W2082401112","https://openalex.org/W2090389306","https://openalex.org/W2090898843","https://openalex.org/W2099209706","https://openalex.org/W2128113643","https://openalex.org/W2129276307","https://openalex.org/W2131310568","https://openalex.org/W2138450406","https://openalex.org/W2227174102","https://openalex.org/W2238440277","https://openalex.org/W2337328173","https://openalex.org/W2358927500","https://openalex.org/W2399644778","https://openalex.org/W2400228013","https://openalex.org/W2411812279","https://openalex.org/W2432263744","https://openalex.org/W4298347324"],"related_works":["https://openalex.org/W2136301623","https://openalex.org/W2257311363","https://openalex.org/W2411812279","https://openalex.org/W2082401112","https://openalex.org/W2357859346","https://openalex.org/W2238440277","https://openalex.org/W2073602735","https://openalex.org/W2399644778","https://openalex.org/W2029045905","https://openalex.org/W1967380913"],"abstract_inverted_index":{"The":[0],"mechanism":[1],"underlying":[2],"H2O2-induced":[3,179],"activation":[4,181],"of":[5,24,62,67,94,98,106,139,161,169],"frog":[6],"skeletal":[7],"muscle":[8,183],"ryanodine":[9],"receptors":[10],"was":[11],"studied":[12],"using":[13],"skinned":[14,25],"fibers":[15,26],"and":[16,53,73,182],"by":[17,113,131,159],"measuring":[18],"single":[19],"Ca(2+)-release":[20,43,174],"channel":[21,90,108,175,180],"current.":[22],"Exposure":[23,79],"to":[27,80,87,102,122,128,142,178],"3-10":[28],"mM":[29,37,85,100,134],"H2O2":[30,34,63,82,101,135,152],"elicited":[31,130],"spontaneous":[32],"contractures.":[33],"at":[35,83],"1":[36],"potentiated":[38],"caffeine":[39],"contracture.":[40,184],"When":[41],"the":[42,65,89,92,103,162,173],"channels":[44,143],"were":[45,57,76],"incorporated":[46],"into":[47],"lipid":[48],"bilayers,":[49],"open":[50,54],"probability":[51],"(Po)":[52],"time":[55],"constants":[56],"increased":[58],"on":[59],"intraluminal":[60],"addition":[61],"in":[64,91,125,155,172],"presence":[66,93],"cis":[68,81,114,140],"catalase,":[69],"but":[70],"unitary":[71],"conductance":[72],"reversal":[74],"potential":[75],"not":[77],"affected.":[78],"1.5":[84,99,133],"failed":[86],"activate":[88],"trans":[95,104,132,151],"catalase.":[96],"Application":[97],"side":[105],"a":[107],"that":[109,129,144,167],"had":[110,145],"been":[111,146],"oxidized":[112],"p-chloromercuriphenylsulfonic":[115],"acid":[116],"(pCMPS;":[117],"50":[118],"microM)":[119],"still":[120],"led":[121],"an":[123],"increase":[124],"Po,":[126],"comparable":[127],"without":[136,150],"pCMPS.":[137],"Addition":[138],"pCMPS":[141],"treated":[147],"with":[148],"or":[149],"rapidly":[153],"resulted":[154],"high":[156],"Po":[157],"followed":[158],"closure":[160],"channel.":[163],"These":[164],"results":[165],"suggest":[166],"oxidation":[168],"luminal":[170],"sulfhydryls":[171],"may":[176],"contribute":[177]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
