{"id":"https://openalex.org/W2312811751","doi":"https://doi.org/10.1021/acs.molpharmaceut.5b00989","title":"Synthesis and Preclinical Evaluation of Folate-NOTA-Al18F for PET Imaging of Folate-Receptor-Positive Tumors","display_name":"Synthesis and Preclinical Evaluation of Folate-NOTA-Al18F for PET Imaging of Folate-Receptor-Positive Tumors","publication_year":2016,"publication_date":"2016-04-07","ids":{"openalex":"https://openalex.org/W2312811751","doi":"https://doi.org/10.1021/acs.molpharmaceut.5b00989","mag":"2312811751","pmid":"https://pubmed.ncbi.nlm.nih.gov/27054811","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5343510"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.5b00989","doi":"https://doi.org/10.1021/acs.molpharmaceut.5b00989","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.5b00989","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5343510","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076012975","display_name":"Qingshou Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingshou Chen","raw_affiliation_strings":["Department\rof Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686444","display_name":"Xiangjun Meng","orcid":"https://orcid.org/0000-0001-5266-603X","observed_orcids":["https://orcid.org/0000-0001-5266-603X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangjun Meng","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001482204","display_name":"Paul S. Mcquade","orcid":"https://orcid.org/0000-0003-0282-0208","observed_orcids":["https://orcid.org/0000-0003-0282-0208"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul McQuade","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019927985","display_name":"Daniel J. Rubins","orcid":"https://orcid.org/0000-0002-1587-6190","observed_orcids":["https://orcid.org/0000-0002-1587-6190"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Rubins","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089328305","display_name":"Shu-An Lin","orcid":"https://orcid.org/0000-0002-2290-1657","observed_orcids":["https://orcid.org/0000-0002-2290-1657"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu-An Lin","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030724313","display_name":"Zhizhen Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhizhen Zeng","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027205093","display_name":"Hyking Haley","orcid":"https://orcid.org/0000-0001-6705-2276","observed_orcids":["https://orcid.org/0000-0001-6705-2276"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyking Haley","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103931921","display_name":"Patricia J. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Miller","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411282","display_name":"D. E. Gonz\u00e1lez Trotter","orcid":"https://orcid.org/0009-0005-5862-403X","observed_orcids":["https://orcid.org/0009-0005-5862-403X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dinko Gonz\u00e1lez Trotter","raw_affiliation_strings":["Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012446734","display_name":"Philip Stewart Low","orcid":"https://orcid.org/0000-0001-9042-5528","observed_orcids":["https://orcid.org/0000-0001-9042-5528"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip S. Low","raw_affiliation_strings":["Department\rof Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, United States","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012446734"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.3927,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.94514467,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"13","issue":"5","first_page":"1520","last_page":"1527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.777999997138977},{"id":"https://openalex.org/keywords/nota-chelator","display_name":"NOTA chelator","score":0.8859999775886536},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.625},{"id":"https://openalex.org/keywords/radiopharmaceutical-synthesis","display_name":"radiopharmaceutical synthesis","score":0.671999990940094},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9470000267028809},{"id":"https://openalex.org/keywords/micropet-imaging","display_name":"microPET imaging","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.9463986158370972},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7873700261116028},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7541779279708862},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.6390326023101807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5906445384025574},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.520659327507019},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5137432813644409},{"id":"https://openalex.org/C2778172261","wikidata":"https://www.wikidata.org/wiki/Q3796563","display_name":"Imaging agent","level":3,"score":0.4983255863189697},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4489089250564575},{"id":"https://openalex.org/C2776970183","wikidata":"https://www.wikidata.org/wiki/Q20155580","display_name":"Radiosynthesis","level":3,"score":0.43499869108200073},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.43333572149276733},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43140357732772827},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3219563364982605},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.2914294898509979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2768632769584656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20547473430633545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17676085233688354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12052208185195923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11533159017562866},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.10114046931266785},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007624","descriptor_name":"KB Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011854","descriptor_name":"Radiochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.5b00989","doi":"https://doi.org/10.1021/acs.molpharmaceut.5b00989","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.5b00989","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:27054811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27054811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4261075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5343510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5343510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5343510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharm","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4261075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5343510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5341518688","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA023168","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310510","display_name":"Endocyte","ror":"https://ror.org/058dk4619"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W324626284","https://openalex.org/W1750338110","https://openalex.org/W1842119567","https://openalex.org/W1969552935","https://openalex.org/W1971135844","https://openalex.org/W1973189779","https://openalex.org/W1979398201","https://openalex.org/W1989086186","https://openalex.org/W1990585331","https://openalex.org/W1993215855","https://openalex.org/W1993388378","https://openalex.org/W1994337577","https://openalex.org/W1995094885","https://openalex.org/W1995291470","https://openalex.org/W1997316232","https://openalex.org/W1997391860","https://openalex.org/W2000768445","https://openalex.org/W2006121719","https://openalex.org/W2008644522","https://openalex.org/W2008935100","https://openalex.org/W2015182838","https://openalex.org/W2015266666","https://openalex.org/W2017495608","https://openalex.org/W2019233094","https://openalex.org/W2020489397","https://openalex.org/W2021734166","https://openalex.org/W2030948038","https://openalex.org/W2036302880","https://openalex.org/W2037088441","https://openalex.org/W2048708446","https://openalex.org/W2049368147","https://openalex.org/W2060350340","https://openalex.org/W2065452497","https://openalex.org/W2067848116","https://openalex.org/W2070002280","https://openalex.org/W2087899096","https://openalex.org/W2089645494","https://openalex.org/W2098735745","https://openalex.org/W2102695123","https://openalex.org/W2117500484","https://openalex.org/W2124268014","https://openalex.org/W2124948344","https://openalex.org/W2133127259","https://openalex.org/W2143042600","https://openalex.org/W2151523321","https://openalex.org/W2187906663","https://openalex.org/W2273284902","https://openalex.org/W2314966989","https://openalex.org/W2315187861","https://openalex.org/W2322600650","https://openalex.org/W2323389052","https://openalex.org/W2324107401","https://openalex.org/W2331783597","https://openalex.org/W2332816654","https://openalex.org/W2342326117","https://openalex.org/W4239756883"],"related_works":["https://openalex.org/W2762594267","https://openalex.org/W2582493126","https://openalex.org/W3093522712","https://openalex.org/W4400559345","https://openalex.org/W4400919023","https://openalex.org/W2588656173","https://openalex.org/W3028898334","https://openalex.org/W2492501745","https://openalex.org/W6987492536","https://openalex.org/W2102695123"],"abstract_inverted_index":{"UNLABELLED:":[0],"Folate-receptor-targeted":[1],"PET":[2,30,281],"radiotracers":[3],"can":[4,32],"potentially":[5],"serve":[6],"as":[7,141],"versatile":[8],"imaging":[9,146,207,256,282],"agents":[10],"for":[11,66,100,111,291,320],"the":[12,107,133,167,184,272],"diagnosis,":[13,324],"staging,":[14],"and":[15,78,85,128,135,163,171,179,186,213,237,254,271,288,325],"prediction":[16],"of":[17,21,91,109,118,126,137,166,188,194,200,215,226,233,240,245,251,327],"response":[18],"to":[19,55,120,318],"therapy":[20],"patients":[22,328],"with":[23,98,198,258,284,329],"folate-receptor":[24],"(FR)-expressing":[25],"cancers.":[26,331],"Because":[27],"current":[28],"FR-targeted":[29,280],"reagents":[31],"be":[33,63],"compromised":[34],"by":[35,95,104,176],"complex":[36],"labeling":[37],"procedures,":[38],"low":[39],"specific":[40,164,224],"activities,":[41],"poor":[42],"radiochemical":[43,211,231,238],"yields,":[44],"or":[45,157],"unwanted":[46],"accumulation":[47,165],"in":[48,83,86,106,124,132,169,183,267,322],"FR":[49,121,246],"negative":[50],"tissues,":[51],"we":[52,72,310],"have":[53,73],"undertaken":[54],"design":[56],"an":[57,268,277],"improved":[58,285,298],"folate-PET":[59],"agent":[60,283],"that":[61,199,312],"might":[62],"more":[64],"amenable":[65],"clinical":[67],"development.":[68],"For":[69],"this":[70],"purpose,":[71],"synthesized":[74],"a":[75,142,202,223,249,315],"folate-NOTA-Al(18)F":[76,92,119,195,216,313],"radiotracer":[77,168],"examined":[79],"its":[80,297],"properties":[81,287,299],"both":[82],"vitro":[84],"vivo.":[87],"METHODS:":[88],"Radiochemical":[89],"synthesis":[90,212],"was":[93,122,147,174,196,217],"achieved":[94],"incubating":[96],"(18)F(-)":[97],"AlCl3":[99],"2":[101],"min":[102,113],"followed":[103],"heating":[105],"presence":[108,134,185],"folate-NOTA":[110],"15":[112],"at":[114],"100":[115],"\u00b0C.":[116],"Binding":[117],"quantitated":[123],"homogenates":[125],"KB":[127],"Cal51":[129],"tumor":[130,161,170,270],"xenografts":[131],"absence":[136,187],"excess":[138,189],"folic":[139,190],"acid":[140],"competitor.":[143],"In":[144],"vivo":[145,181,260],"performed":[148],"on":[149],"nu/nu":[150],"mice":[151],"bearing":[152],"either":[153],"FR+ve":[154],"(KB":[155],"cell)":[156,160],"FR-ve":[158],"(A549":[159],"xenografts,":[162],"other":[172],"tissues":[173],"assessed":[175],"high-resolution":[177],"micro-PET":[178,255],"ex":[180,259],"biodistribution":[182,261],"acid.":[191],"Image":[192],"quality":[193],"compared":[197],"(99m)Tc-EC20,":[201],"clinically":[203],"established":[204],"folate-targeted":[205],"SPECT":[206],"agent.":[208],"RESULTS:":[209],"Total":[210],"purification":[214],"completed":[218],"within":[219],"37":[220],"min,":[221],"yielding":[222],"activity":[225],"68.82":[227],"\u00b1":[228,235,242],"18.5":[229],"GBq/\u03bcmol,":[230],"yield":[232],"18.6":[234],"4.5%,":[236],"purity":[239],"98.3":[241],"2.9%.":[243],"Analysis":[244],"binding":[247],"revealed":[248],"Kd":[250],"\u223c1.0":[252],"nM,":[253],"together":[257],"analyses":[262],"demonstrated":[263],"high":[264,289],"FR-mediated":[265],"uptake":[266],"FR+":[269],"kidneys.":[273],"CONCLUSIONS:":[274],"Folate-NOTA-Al(18)F":[275],"constitutes":[276,314],"easily":[278],"prepared":[279],"radiopharmaceutical":[286],"specificity":[290],"folate":[292],"receptor":[293],"expressing":[294],"tumors.":[295],"Given":[296],"over":[300],"(99m)Tc-EC20":[301,319],"(i.e.,":[302],"higher":[303],"resolution,":[304],"shorter":[305],"image":[306],"acquisition":[307],"time,":[308],"etc.),":[309],"conclude":[311],"viable":[316],"alternative":[317],"use":[321],"identification,":[323],"staging":[326],"FR-expressing":[330]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}