{"id":"https://openalex.org/W2312809598","doi":"https://doi.org/10.1055/s-0034-1374865","title":"Identifizierung der Mutation im Dock8 Gen in der LEW.1AR1-iddm Ratte, einem Tiermodell des humanen Typ 1 Diabetes mellitus","display_name":"Identifizierung der Mutation im Dock8 Gen in der LEW.1AR1-iddm Ratte, einem Tiermodell des humanen Typ 1 Diabetes mellitus","publication_year":2014,"publication_date":"2014-05-06","ids":{"openalex":"https://openalex.org/W2312809598","doi":"https://doi.org/10.1055/s-0034-1374865","mag":"2312809598"},"language":"de","primary_location":{"id":"doi:10.1055/s-0034-1374865","doi":"https://doi.org/10.1055/s-0034-1374865","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1374865","pdf_url":null,"source":{"id":"https://openalex.org/S26605106","display_name":"Diabetologie und Stoffwechsel","issn_l":"1861-9002","issn":["1861-9002","1861-9010"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologie und Stoffwechsel","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000623957","display_name":"T Arndt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Arndt","raw_affiliation_strings":["Medizinische Hochschule Hannover, Institut f\u00fcr Klinische Biochemie, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Institut f\u00fcr Klinische Biochemie, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Wedekind","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D Wedekind","raw_affiliation_strings":["Medizinische Hochschule Hannover, Institut f\u00fcr Versuchstierkunde, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Institut f\u00fcr Versuchstierkunde, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091222608","display_name":"Anne J\u00f6rns","orcid":"https://orcid.org/0000-0003-0176-972X","observed_orcids":["https://orcid.org/0000-0003-0176-972X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A J\u00f6rns","raw_affiliation_strings":["Medizinische Hochschule Hannover, Institut f\u00fcr Klinische Biochemie, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Institut f\u00fcr Klinische Biochemie, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033411682","display_name":"Georgios Tsiavaliaris","orcid":"https://orcid.org/0000-0002-5161-4884","observed_orcids":["https://orcid.org/0000-0002-5161-4884"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Tsiavaliaris","raw_affiliation_strings":["Medizinische Hochschule Hannover, Institut f\u00fcr Biophysikalische Chemie, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Institut f\u00fcr Biophysikalische Chemie, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072084304","display_name":"Edwin P. J. G. Cuppen","orcid":"https://orcid.org/0000-0002-0400-9542","observed_orcids":["https://orcid.org/0000-0002-0400-9542"]},"institutions":[{"id":"https://openalex.org/I4210115206","display_name":"Hubrecht Institute for Developmental Biology and Stem Cell Research","ror":"https://ror.org/023qc4a07","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1322597698","https://openalex.org/I4210115206"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E Cuppen","raw_affiliation_strings":["Hubrecht Institut, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubrecht Institut, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210115206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013830553","display_name":"HJ Hedrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"HJ Hedrich","raw_affiliation_strings":["Medizinische Hochschule Hannover, Institut f\u00fcr Versuchstierkunde, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Institut f\u00fcr Versuchstierkunde, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043148796","display_name":"Sigurd Lenzen","orcid":"https://orcid.org/0000-0003-2125-8193","observed_orcids":["https://orcid.org/0000-0003-2125-8193"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Lenzen","raw_affiliation_strings":["Medizinische Hochschule Hannover, Institut f\u00fcr Klinische Biochemie, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Hochschule Hannover, Institut f\u00fcr Klinische Biochemie, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18833933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"S 01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/diabetic-rats","display_name":"diabetic rats","score":0.6119999885559082},{"id":"https://openalex.org/keywords/fine-mapping","display_name":"fine mapping","score":0.6299999952316284},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8999999761581421},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.42800000309944153},{"id":"https://openalex.org/keywords/backcross-populations","display_name":"backcross populations","score":0.7400000095367432},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5896012187004089},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4711134731769562},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4165356457233429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20545604825019836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0034-1374865","doi":"https://doi.org/10.1055/s-0034-1374865","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1374865","pdf_url":null,"source":{"id":"https://openalex.org/S26605106","display_name":"Diabetologie und Stoffwechsel","issn_l":"1861-9002","issn":["1861-9002","1861-9010"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologie und Stoffwechsel","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1951469632","https://openalex.org/W2030757128","https://openalex.org/W2316648942","https://openalex.org/W2092071297","https://openalex.org/W2090649530","https://openalex.org/W2059143109","https://openalex.org/W2888330174","https://openalex.org/W2036460674","https://openalex.org/W1986697733","https://openalex.org/W2516209811"],"abstract_inverted_index":{"Hintergrund:":[0],"Die":[1,69,107,208,234],"LEW.1AR1-":[2,133,212,235],"iddm":[3,134,183,213,236],"Ratte":[4,135,237],"ist":[5,15],"ein":[6],"Tiermodell":[7],"des":[8,169],"humanen":[9],"Typ":[10],"1":[11,45],"Diabetes":[12],"mellitus.":[13],"Sie":[14],"zus\u00e4tzlich":[16],"charakterisiert":[17],"durch":[18],"einen":[19,113],"variierenden":[20,203,221],"T-Zellanteil":[21,204],"im":[22,115,164,229],"peripheren":[23],"Blut.":[24],"Mithilfe":[25,180],"zweier":[26],"R\u00fcckkreuzungspopulationen":[27,77],"mit":[28,175],"dem":[29,32,218],"BN":[30],"und":[31,162],"PAR":[33],"Stamm":[34],"unter":[35,78],"Ber\u00fccksichtigung":[36],"beider":[37,76],"Ph\u00e4notypen":[38],"konnte":[39,100,187,228],"die":[40,57,101,173,191,197,215,240,247,254],"Iddm8":[41,59,72,103],"Suszeptibilit\u00e4tsregion":[42,102],"auf":[43,246,253],"Chromosom":[44],"als":[46,87,199,223],"Bereich":[47],"der":[48,53,71,132,142,144,166,211,220],"Mutation":[49,192,209],"kartiert":[50],"werden.":[51,106,233],"Ziel":[52],"Studie":[54],"war":[55],"es,":[56],"Region":[58,73],"mittels":[60,75],"SNP":[61,98],"Analysen":[62,99],"einzugrenzen":[63],"sowie":[64],"Kandiadatengene":[65],"zu":[66,136,141,155,160,217,256],"identifizieren.":[67],"Methoden:":[68],"Feinkartierung":[70],"erfolgte":[74],"Einsatz":[79],"von":[80,109,158,244],"SNPs":[81],"(":[82,117,146],"single":[83],"nucleotide":[84],"polymorphisms":[85],")":[86,122,150],"informative":[88],"Marker.":[89],"In":[90],"eingegrenzten":[91],"Suszeptibilit\u00e4tsregionen":[92],"wurden":[93],"Kandidatengene":[94],"sequenziert.":[95],"Ergebnisse:":[96],"Durch":[97],"deutlich":[104],"verkleinert":[105],"Sequenzierung":[108],"Kandidatengenen":[110],"zeigte":[111],"sodann":[112],"Basenaustausch":[114,153],"Dock8":[116,139,194,230],"dedicator":[118],"of":[119],"cytokinesis":[120],"8":[121],"Gen":[123,231],"in":[124,131,193,210,251],"Exon":[125],"44":[126],"Position":[127],"228,622,763,":[128],"welcher":[129],"nur":[130],"finden":[137],"war.":[138],"geh\u00f6rt":[140],"Superfamilie":[143],"GEF":[145],"guanine":[147],"exchange":[148],"factor":[149],"Proteine.":[151],"Dieser":[152],"f\u00fchrt":[154],"einem":[156],"Aminos\u00e4urenaustausch":[157],"Glutamin":[159],"Glutamat":[161],"lokalisiert":[163],"\u00df4-Faltblatt":[165],"DHR2":[167],"Dom\u00e4ne":[168],"Proteins,":[170],"welche":[171],"f\u00fcr":[172,196,201],"Interaktion":[174],"Cdc42":[176],"(GTPase)":[177],"verantwortlich":[178,205],"ist.":[179,206],"einer":[181],"(LEW.1AR1-":[182],"x":[184],"LEW.1AR1)":[185],"F2":[186],"nachgewiesen":[188],"werden,":[189],"dass":[190],"sowohl":[195,216],"Diabetesentwicklung":[198,226,255],"auch":[200,224],"den":[202,242],"Schlussfolgerungen:":[207],"Ratte,":[214],"Ph\u00e4notyp":[219],"T-Zellen":[222],"zur":[225],"f\u00fchrt,":[227],"identifiziert":[232],"bietet":[238],"somit":[239],"M\u00f6glichkeit,":[241],"Einfluss":[243],"GEFs":[245],"Funktion":[248],"verschiedener":[249],"Immunzellen":[250],"Hinblick":[252],"untersuchen.":[257]},"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2016-06-24T00:00:00"}
