{"id":"https://openalex.org/W2312367341","doi":"https://doi.org/10.14235/bs.2014.233","title":"Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer\u2019s Disease","display_name":"Lamiaceae Family Plants as a Potential Anticholinesterase Source in the Treatment of Alzheimer\u2019s Disease","publication_year":2014,"publication_date":"2014-05-06","ids":{"openalex":"https://openalex.org/W2312367341","doi":"https://doi.org/10.14235/bs.2014.233","mag":"2312367341"},"language":"en","primary_location":{"id":"doi:10.14235/bs.2014.233","doi":"https://doi.org/10.14235/bs.2014.233","is_oa":true,"landing_page_url":"https://doi.org/10.14235/bs.2014.233","pdf_url":"https://doi.org/10.14235/bs.2014.233","source":{"id":"https://openalex.org/S4210191091","display_name":"Bezmialem Science","issn_l":"2148-2373","issn":["2148-2373"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bezmialem Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.14235/bs.2014.233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014248621","display_name":"G\u00fcla\u00e7t\u0131 Top\u00e7u","orcid":"https://orcid.org/0000-0002-7946-6545","observed_orcids":["https://orcid.org/0000-0002-7946-6545"]},"institutions":[{"id":"https://openalex.org/I3125175737","display_name":"Bezmi\u00e2lem Vak\u0131f \u00dcniversitesi","ror":"https://ror.org/04z60tq39","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125175737"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gulacti TOPCU","raw_affiliation_strings":["KUSMAN Faculty of Pharmacy , Bezmialem Vakif University , Istanbul , Turkey","Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KUSMAN Faculty of Pharmacy , Bezmialem Vakif University , Istanbul , Turkey","institution_ids":["https://openalex.org/I3125175737"]},{"raw_affiliation_string":"Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey","institution_ids":["https://openalex.org/I3125175737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037857378","display_name":"Tuba Ku\u015fman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3125175737","display_name":"Bezmi\u00e2lem Vak\u0131f \u00dcniversitesi","ror":"https://ror.org/04z60tq39","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125175737"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tuba KUSMAN","raw_affiliation_strings":["Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey","institution_ids":["https://openalex.org/I3125175737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014248621"],"corresponding_institution_ids":["https://openalex.org/I3125175737"],"apc_list":null,"apc_paid":null,"fwci":1.5448,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.80200737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"1","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lamiaceae","display_name":"Lamiaceae","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9549999833106995},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.8019999861717224},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.8730000257492065},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9819999933242798},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.75},{"id":"https://openalex.org/keywords/galantamine","display_name":"galantamine","score":0.7799999713897705},{"id":"https://openalex.org/keywords/rivastigmine","display_name":"rivastigmine","score":0.8519999980926514},{"id":"https://openalex.org/keywords/physostigmine","display_name":"physostigmine","score":0.8510000109672546},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.7820000052452087},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6690000295639038},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2776332859","wikidata":"https://www.wikidata.org/wiki/Q411887","display_name":"Rivastigmine","level":5,"score":0.9662802219390869},{"id":"https://openalex.org/C2779056891","wikidata":"https://www.wikidata.org/wiki/Q412690","display_name":"Galantamine","level":5,"score":0.9374855756759644},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.8848083019256592},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.8082666397094727},{"id":"https://openalex.org/C2779046751","wikidata":"https://www.wikidata.org/wiki/Q421076","display_name":"Tacrine","level":4,"score":0.7630161046981812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7557387351989746},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5874947905540466},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.5212422013282776},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5135028958320618},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48935216665267944},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47355714440345764},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.430338591337204},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41122332215309143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17337089776992798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09497177600860596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.14235/bs.2014.233","doi":"https://doi.org/10.14235/bs.2014.233","is_oa":true,"landing_page_url":"https://doi.org/10.14235/bs.2014.233","pdf_url":"https://doi.org/10.14235/bs.2014.233","source":{"id":"https://openalex.org/S4210191091","display_name":"Bezmialem Science","issn_l":"2148-2373","issn":["2148-2373"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bezmialem Science","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.680.9279","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.680.9279","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bezmialemscience.org/sayilar/4/buyuk/1-25.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6593e3f9acb048bcb8f264c033f12604","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6593e3f9acb048bcb8f264c033f12604","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bezmi\u00e2lem Science, Vol 2, Iss 1, Pp 1-25 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.14235/bs.2014.233","doi":"https://doi.org/10.14235/bs.2014.233","is_oa":true,"landing_page_url":"https://doi.org/10.14235/bs.2014.233","pdf_url":"https://doi.org/10.14235/bs.2014.233","source":{"id":"https://openalex.org/S4210191091","display_name":"Bezmialem Science","issn_l":"2148-2373","issn":["2148-2373"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bezmialem Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5263109630","display_name":null,"funder_award_id":"TBAG-107T592","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2312367341.pdf","grobid_xml":"https://content.openalex.org/works/W2312367341.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W93632731","https://openalex.org/W144495947","https://openalex.org/W168715043","https://openalex.org/W196101082","https://openalex.org/W1481497570","https://openalex.org/W1528685627","https://openalex.org/W1583413683","https://openalex.org/W1594248439","https://openalex.org/W1597763393","https://openalex.org/W1647994195","https://openalex.org/W1953450639","https://openalex.org/W1965761548","https://openalex.org/W1967774489","https://openalex.org/W1972489335","https://openalex.org/W1973885230","https://openalex.org/W1974982507","https://openalex.org/W1976281831","https://openalex.org/W1976684992","https://openalex.org/W1977267337","https://openalex.org/W1977398572","https://openalex.org/W1977608425","https://openalex.org/W1977998549","https://openalex.org/W1983945098","https://openalex.org/W1984769657","https://openalex.org/W1988193891","https://openalex.org/W1989112928","https://openalex.org/W1990307779","https://openalex.org/W1991078390","https://openalex.org/W1999354084","https://openalex.org/W2002246326","https://openalex.org/W2002315759","https://openalex.org/W2003432960","https://openalex.org/W2003701345","https://openalex.org/W2004585737","https://openalex.org/W2005742833","https://openalex.org/W2008428005","https://openalex.org/W2009965236","https://openalex.org/W2012096582","https://openalex.org/W2015774675","https://openalex.org/W2017450083","https://openalex.org/W2017952084","https://openalex.org/W2020660605","https://openalex.org/W2023967416","https://openalex.org/W2025092303","https://openalex.org/W2025844567","https://openalex.org/W2026879452","https://openalex.org/W2028451640","https://openalex.org/W2031561250","https://openalex.org/W2032183897","https://openalex.org/W2032303179","https://openalex.org/W2033637544","https://openalex.org/W2034907347","https://openalex.org/W2041158988","https://openalex.org/W2043043846","https://openalex.org/W2050206187","https://openalex.org/W2052453538","https://openalex.org/W2052645853","https://openalex.org/W2052847188","https://openalex.org/W2055691922","https://openalex.org/W2059377071","https://openalex.org/W2061744759","https://openalex.org/W2064299673","https://openalex.org/W2064860329","https://openalex.org/W2066051584","https://openalex.org/W2066708204","https://openalex.org/W2067222952","https://openalex.org/W2067816865","https://openalex.org/W2073567243","https://openalex.org/W2074259977","https://openalex.org/W2078548800","https://openalex.org/W2079286054","https://openalex.org/W2079570556","https://openalex.org/W2082213920","https://openalex.org/W2083560899","https://openalex.org/W2083683595","https://openalex.org/W2083765618","https://openalex.org/W2085784683","https://openalex.org/W2086367367","https://openalex.org/W2088490840","https://openalex.org/W2091401166","https://openalex.org/W2092047588","https://openalex.org/W2093181477","https://openalex.org/W2093607636","https://openalex.org/W2093786094","https://openalex.org/W2103732576","https://openalex.org/W2105718579","https://openalex.org/W2110744130","https://openalex.org/W2116642619","https://openalex.org/W2116984154","https://openalex.org/W2118020656","https://openalex.org/W2122429894","https://openalex.org/W2127817386","https://openalex.org/W2135336998","https://openalex.org/W2139241586","https://openalex.org/W2151815081","https://openalex.org/W2165537450","https://openalex.org/W2168135047","https://openalex.org/W2199940260","https://openalex.org/W2312493906","https://openalex.org/W2320261624","https://openalex.org/W2332151508","https://openalex.org/W2343963060","https://openalex.org/W2398740439","https://openalex.org/W2408697614","https://openalex.org/W2429296312","https://openalex.org/W2488470729","https://openalex.org/W2496985709","https://openalex.org/W2506766117","https://openalex.org/W2952094713","https://openalex.org/W3008009061","https://openalex.org/W3009949247","https://openalex.org/W4251931133","https://openalex.org/W6643446636"],"related_works":["https://openalex.org/W7097593628","https://openalex.org/W1528685627","https://openalex.org/W3199985966","https://openalex.org/W7061329816","https://openalex.org/W2893930979","https://openalex.org/W7162140150","https://openalex.org/W2116642619","https://openalex.org/W2130936553","https://openalex.org/W4213205152","https://openalex.org/W2008648606"],"abstract_inverted_index":{"Alzheimer's":[0,120,177],"disease":[1],"(AD)":[2],"is":[3,39,42,74,80,96],"one":[4],"of":[5,20,31,51,83,105,113,146,163,176],"the":[6,16,49,60,84,100,103,144,174],"most":[7],"common":[8],"and":[9,41,63,70,78,122,137,160,165],"progressive":[10],"neurodegenerative":[11],"disorders":[12],"with":[13,107],"dementia":[14],"in":[15,102,173],"world.The":[17],"precise":[18],"causes":[19],"AD":[21,37],"are":[22,34,54,124,168],"not":[23,45],"fully":[24],"understood":[25],"yet,":[26],"although":[27],"several":[28],"important":[29],"features":[30],"its":[32],"pathophysiology":[33],"well":[35],"described.Current":[36],"treatment":[38,104,118,175],"symptomatic":[40],"mainly,":[43],"but":[44],"exclusively,":[46],"focused":[47],"on":[48,127,143],"inhibition":[50],"cholinesterases":[52],"(ChEs).There":[53],"four":[55],"cholinesterase":[56,148],"inhibitors":[57,149],"approved":[58,98],"by":[59,99],"U.S.":[61],"Food":[62],"Drug":[64],"Administration":[65],"(FDA):":[66],"tacrine,":[67],"donepezil,":[68],"rivastigmine,":[69],"galantamine.Among":[71],"them,":[72],"galantamine":[73],"a":[75,81,116,161],"natural":[76,85,138,151],"drug,":[77],"rivastigmine":[79],"derivative":[82],"drug":[86],"physostigmine.In":[87],"addition,":[88],"only":[89],"an":[90],"NMDA":[91],"(N-methyl-D-aspartate)":[92],"receptor":[93],"antagonist,":[94],"memantine,":[95],"also":[97],"FDA":[101],"patients":[106],"moderate":[108],"to":[109,128],"severe":[110],"AD.However,":[111],"none":[112],"them":[114],"provides":[115],"satisfactory":[117],"for":[119],"disease,":[121],"studies":[123,142],"still":[125],"going":[126],"find":[129],"new":[130,147],"potential":[131,171],"drugs":[132,172],"from":[133,150,154],"both":[134],"synthetic":[135],"chemicals":[136],"sources.In":[139],"this":[140],"review,":[141],"discovery":[145],"sources,":[152],"particularly":[153],"Lamiaceae":[155],"family":[156],"plants":[157],"were":[158],"evaluated,":[159],"number":[162],"terpenoids":[164],"phenolics/flavonoids":[166],"isolated":[167],"presented":[169],"as":[170],"disease.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}