{"id":"https://openalex.org/W2311987167","doi":null,"title":"Angiopoietin-2 overexpression in morris hepatoma results in increased tumor perfusion and induction of critical angiogenesis-promoting genes.","display_name":"Angiopoietin-2 overexpression in morris hepatoma results in increased tumor perfusion and induction of critical angiogenesis-promoting genes.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W2311987167","mag":"2311987167","pmid":"https://pubmed.ncbi.nlm.nih.gov/16954561"},"language":"en","primary_location":{"id":"pmid:16954561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16954561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112067098","display_name":"Pierre Kunz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Pierre Kunz","raw_affiliation_strings":["Department of Anatomy and Cell Biology III, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology III, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005601239","display_name":"Johannes Hoffend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Hoffend","raw_affiliation_strings":["University of Heidelberg#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg#TAB#","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082176296","display_name":"Annette Altmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette Altmann","raw_affiliation_strings":["German Cancer Research Center (DKFZ)","University of Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Center (DKFZ)","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"University of Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008622761","display_name":"Antonia Dimitrakopoulou\u2010Strauss","orcid":"https://orcid.org/0000-0003-0338-9472","observed_orcids":["https://orcid.org/0000-0003-0338-9472"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antonia Dimitrakopoulou-Strauss","raw_affiliation_strings":["German Cancer Research Center (dkfz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Center (dkfz","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060233539","display_name":"Dirk Koczan","orcid":"https://orcid.org/0000-0002-3183-998X","observed_orcids":["https://orcid.org/0000-0002-3183-998X"]},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Koczan","raw_affiliation_strings":["University of  Rostock"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of  Rostock","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051876759","display_name":"Michael Eisenhut","orcid":"https://orcid.org/0000-0002-8505-1186","observed_orcids":["https://orcid.org/0000-0002-8505-1186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Eisenhut","raw_affiliation_strings":["Imaging and Radiooncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Radiooncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024745372","display_name":"Gabriel A. Bonaterra","orcid":"https://orcid.org/0000-0002-8660-9014","observed_orcids":["https://orcid.org/0000-0002-8660-9014"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriel A Bonaterra","raw_affiliation_strings":["University of Heidelberg#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg#TAB#","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109084012","display_name":"Thomas J. Dengler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas J Dengler","raw_affiliation_strings":["University of Heidelberg#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg#TAB#","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010448744","display_name":"Walter Mier","orcid":"https://orcid.org/0000-0002-3901-5061","observed_orcids":["https://orcid.org/0000-0002-3901-5061"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Walter Mier","raw_affiliation_strings":["University of Heidelberg#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg#TAB#","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010632119","display_name":"Uwe Haberkorn","orcid":"https://orcid.org/0000-0001-6630-0338","observed_orcids":["https://orcid.org/0000-0001-6630-0338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe Haberkorn","raw_affiliation_strings":["Imaging and Radiooncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Radiooncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053068157","display_name":"Ralf Kinscherf","orcid":"https://orcid.org/0000-0002-5506-7398","observed_orcids":["https://orcid.org/0000-0002-5506-7398"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Kinscherf","raw_affiliation_strings":["University of Heidelberg#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Heidelberg#TAB#","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.449,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.52966143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"47","issue":"9","first_page":"1515","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":1.0},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/morris-hepatoma","display_name":"Morris hepatoma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.9390000104904175},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.6639999747276306},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.878000020980835},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5019999742507935},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6949999928474426},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8138372898101807},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6048646569252014},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.581534743309021},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.5316057205200195},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5166780948638916},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48961764574050903},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46752381324768066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4644456207752228},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4643429219722748},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4429028630256653},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.43815121054649353},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4216718375682831},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3892309069633484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38213199377059937},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2596322298049927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09389886260032654},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042501","descriptor_name":"Angiogenic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043925","descriptor_name":"Angiogenesis Inducing Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16954561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16954561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.3291","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.3291","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/47/9/1515.full.pdf","raw_type":"text"},{"id":"mag:2311987167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16954561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1516458390","https://openalex.org/W1565284612","https://openalex.org/W1961498819","https://openalex.org/W1965783357","https://openalex.org/W1966879486","https://openalex.org/W1976513809","https://openalex.org/W1976557192","https://openalex.org/W1986154258","https://openalex.org/W1995585602","https://openalex.org/W1996859043","https://openalex.org/W2012255417","https://openalex.org/W2051487747","https://openalex.org/W2054919355","https://openalex.org/W2066639629","https://openalex.org/W2075506033","https://openalex.org/W2083921492","https://openalex.org/W2086030886","https://openalex.org/W2099122266","https://openalex.org/W2100537119","https://openalex.org/W2100864427","https://openalex.org/W2113920157","https://openalex.org/W2128154767","https://openalex.org/W2138687800","https://openalex.org/W2145621549","https://openalex.org/W2151989484","https://openalex.org/W2152215024","https://openalex.org/W2152525228","https://openalex.org/W2165223841","https://openalex.org/W2170201138","https://openalex.org/W2170770755"],"related_works":["https://openalex.org/W1894622856","https://openalex.org/W2391817231","https://openalex.org/W2166119177","https://openalex.org/W2099928391","https://openalex.org/W2170201138","https://openalex.org/W2063761866","https://openalex.org/W2110944827","https://openalex.org/W2277251767","https://openalex.org/W2423408228","https://openalex.org/W7065579165"],"abstract_inverted_index":{"UNLABELLED:":[0],"Monitoring":[1],"of":[2,28,159,165,177,228],"angiogenesis-relevant":[3],"approaches":[4],"with":[5,51,65,70,124,215],"functional":[6],"imaging":[7],"and":[8,88,96,129,146,198,233,248],"histomorphometric":[9],"analyses":[10],"is":[11],"desirable":[12],"to":[13,23,82,138,191],"evaluate":[14],"the":[15,25,67,125,216],"biologic":[16],"effects.":[17],"In":[18,57],"this":[19],"study":[20],"we":[21],"wished":[22],"examine":[24],"complex":[26],"effects":[27,84],"angiopoietin-2":[29],"(Ang-2)":[30],"gene":[31],"transfer":[32],"in":[33,119,213,240],"a":[34,40,163],"rat":[35],"hepatoma":[36,47],"model.":[37],"METHODS:":[38],"Using":[39],"bicistronic":[41],"retroviral":[42],"vector":[43],"for":[44,230],"Ang-2,":[45],"Morris":[46],"(MH3924A)":[48],"cell":[49,109,143],"lines":[50],"Ang-2":[52,206],"expression":[53,207,227],"were":[54,75,80,92,131],"generated":[55],"(Ang-2-MH3924A).":[56],"human":[58],"umbilical":[59],"vein":[60],"endothelial":[61,108],"cells":[62],"(HUVECs)":[63],"cocultured":[64],"Ang-2-MH3924A,":[66],"proliferative":[68],"action":[69],"or":[71,210],"without":[72,221],"growth":[73,87,106,135,183,218],"factors":[74],"determined.":[76],"Furthermore,":[77],"animal":[78],"experiments":[79],"performed":[81],"measure":[83],"on":[85,246],"tumor":[86,134,223],"perfusion.":[89],"Finally,":[90],"tumors":[91],"examined":[93],"by":[94,114,168],"immunohistochemistry":[95],"DNA":[97,171],"chip":[98,172],"analysis.":[99],"RESULTS:":[100],"Ang-2-expressing":[101],"MH3924A":[102,140],"enhanced":[103,169,226],"basic":[104],"fibroblast":[105],"factor-mediated":[107],"proliferation.":[110],"Perfusion,":[111],"as":[112,186,188],"measured":[113],"H(2)(15)O":[115],"PET,":[116],"was":[117,136],"increased":[118,126,157,166],"genetically":[120],"modified":[121],"tumors.":[122],"Consistent":[123],"perfusion,":[127],"micro-":[128],"macrovascularization":[130],"increased.":[132],"However,":[133],"similar":[137],"wild-type":[139],"(WT-MH3924A).":[141],"Proliferating":[142],"nuclear":[144],"antigen":[145],"TUNEL":[147],"(terminal":[148],"deoxynucleotidyl":[149],"transferase-mediated":[150],"dUTP":[151],"nick-end":[152],"labeling)":[153],"staining":[154],"revealed":[155],"an":[156,175],"number":[158],"positive":[160],"cells,":[161],"indicating":[162],"compensation":[164],"proliferation":[167],"apoptosis.":[170],"analysis":[173],"showed":[174],"induction":[176],"angiogenesis-promoting":[178],"genes,":[179],"including":[180,242],"crucial":[181],"vascular":[182,217],"factor":[184,219],"receptors,":[185],"well":[187],"genes":[189,229],"related":[190],"extracellular":[192],"matrix":[193],"(ECM),":[194],"apoptosis,":[195,232],"signal":[196,234],"transduction,":[197],"oxidative":[199],"stress.":[200],"CONCLUSION:":[201],"Our":[202],"results":[203],"suggest":[204],"that":[205],"increases":[208],"perfusion":[209],"vascularization,":[211],"especially":[212],"interaction":[214],"system,":[220],"affecting":[222],"growth.":[224],"Simultaneous,":[225],"ECM,":[231],"transduction":[235],"indicates":[236],"Ang-2's":[237],"versatile":[238],"role":[239],"angiogenesis":[241],"its":[243],"destabilizing":[244],"function":[245],"ECM":[247],"endothelium.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}