{"id":"https://openalex.org/W2311933341","doi":"https://doi.org/10.1007/s00392-016-0979-8","title":"Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF","display_name":"Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF","publication_year":2016,"publication_date":"2016-03-26","ids":{"openalex":"https://openalex.org/W2311933341","doi":"https://doi.org/10.1007/s00392-016-0979-8","mag":"2311933341","pmid":"https://pubmed.ncbi.nlm.nih.gov/27017514","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4988995"},"language":"en","primary_location":{"id":"doi:10.1007/s00392-016-0979-8","doi":"https://doi.org/10.1007/s00392-016-0979-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00392-016-0979-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00392-016-0979-8.pdf","source":{"id":"https://openalex.org/S81098524","display_name":"Clinical Research in Cardiology","issn_l":"1861-0684","issn":["1861-0684","1861-0692"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research in Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00392-016-0979-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052087260","display_name":"Licette C.Y. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Licette C. Y. Liu","raw_affiliation_strings":["Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074566771","display_name":"Adriaan A. Voors","orcid":"https://orcid.org/0000-0002-5417-4415","observed_orcids":["https://orcid.org/0000-0002-5417-4415","https://orcid.org/0000-0002-8547-2992"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Adriaan A. Voors","raw_affiliation_strings":["Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. a.a.voors@umcg.nl","Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. a.a.voors@umcg.nl","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017097200","display_name":"John R. Teerlink","orcid":"https://orcid.org/0000-0001-9527-0852","observed_orcids":["https://orcid.org/0000-0001-9527-0852"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Teerlink","raw_affiliation_strings":["San Francisco Veterans Affairs Medical Center, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Francisco Veterans Affairs Medical Center, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066769664","display_name":"Gad Cotter","orcid":"https://orcid.org/0000-0002-9613-3339","observed_orcids":["https://orcid.org/0000-0002-9613-3339"]},"institutions":[{"id":"https://openalex.org/I4210137456","display_name":"Momentum Research","ror":"https://ror.org/04p5vvn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gad Cotter","raw_affiliation_strings":["Momentum Research, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Momentum Research, Durham, NC, USA","institution_ids":["https://openalex.org/I4210137456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019809785","display_name":"Beth A. Davison","orcid":"https://orcid.org/0000-0003-2374-6449","observed_orcids":["https://orcid.org/0000-0003-2374-6449"]},"institutions":[{"id":"https://openalex.org/I4210137456","display_name":"Momentum Research","ror":"https://ror.org/04p5vvn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth A. Davison","raw_affiliation_strings":["Momentum Research, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Momentum Research, Durham, NC, USA","institution_ids":["https://openalex.org/I4210137456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022076272","display_name":"Gary Michael Felker","orcid":"https://orcid.org/0000-0002-5931-1239","observed_orcids":["https://orcid.org/0000-0002-5931-1239"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Michael Felker","raw_affiliation_strings":["Duke University School of Medicine, Duke Heart Center, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine, Duke Heart Center, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023320363","display_name":"Gerasimos S Filippatos","orcid":"https://orcid.org/0000-0002-5640-0332","observed_orcids":["https://orcid.org/0000-0002-5640-0332"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Gerasimos Filippatos","raw_affiliation_strings":["School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036249348","display_name":"Yakuan Chen","orcid":"https://orcid.org/0000-0002-0331-0819","observed_orcids":["https://orcid.org/0000-0002-0331-0819"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yakuan Chen","raw_affiliation_strings":["Columbia University Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064906147","display_name":"Barry Greenberg","orcid":"https://orcid.org/0000-0002-6605-9385","observed_orcids":["https://orcid.org/0000-0002-6605-9385"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry H. Greenberg","raw_affiliation_strings":["University of California at San Diego, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017272571","display_name":"Piotr P. Ponikowski","orcid":"https://orcid.org/0000-0002-3391-7064","observed_orcids":["https://orcid.org/0000-0002-3391-7064"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Ponikowski","raw_affiliation_strings":["Clinical Military Hospital, Medical University, Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Military Hospital, Medical University, Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054668121","display_name":"Peter S. Pang","orcid":"https://orcid.org/0000-0003-3444-2811","observed_orcids":["https://orcid.org/0000-0003-3444-2811"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. Pang","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012641937","display_name":"MARGARET FORNEY PRESCOTT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Margaret F. Prescott","raw_affiliation_strings":["Novartis Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108535618","display_name":"Tsushung A. Hua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tsushung A. Hua","raw_affiliation_strings":["Novartis Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051001507","display_name":"Thomas M. Severin","orcid":"https://orcid.org/0000-0001-7203-2042","observed_orcids":["https://orcid.org/0000-0001-7203-2042"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas M. Severin","raw_affiliation_strings":["Novartis Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053760015","display_name":"Marco Metra","orcid":"https://orcid.org/0000-0001-6691-8568","observed_orcids":["https://orcid.org/0000-0001-6691-8568"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Metra","raw_affiliation_strings":["University of Brescia, Brescia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5074566771"],"corresponding_institution_ids":["https://openalex.org/I1334415907"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":4.403,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.94723181,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"105","issue":"9","first_page":"727","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serelaxin","display_name":"serelaxin","score":1.0},{"id":"https://openalex.org/keywords/acute-heart-failure","display_name":"acute heart failure","score":0.996999979019165},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9879999756813049},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.972000002861023},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9484282732009888},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.8167049884796143},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6627770662307739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6215009689331055},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5933570861816406},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5252541899681091},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.49478214979171753},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4907113313674927},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32878005504608154},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07016029953956604},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1007/s00392-016-0979-8","doi":"https://doi.org/10.1007/s00392-016-0979-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00392-016-0979-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00392-016-0979-8.pdf","source":{"id":"https://openalex.org/S81098524","display_name":"Clinical Research in Cardiology","issn_l":"1861-0684","issn":["1861-0684","1861-0692"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research in Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4988995","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4988995","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Res Cardiol","raw_type":"Text"},{"id":"pmid:27017514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27017514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical research in cardiology : official journal of the German Cardiac Society","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/911ef2f8-6e36-4eaa-a605-4ad85d6557ab","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/911ef2f8-6e36-4eaa-a605-4ad85d6557ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liu, L C Y, Voors, A A, Teerlink, J R, Cotter, G, Davison, B A, Felker, G M, Filippatos, G, Chen, Y, Greenberg, B H, Ponikowski, P, Pang, P S, Prescott, M F, Hua, T A, Severin, T M & Metra, M 2016, 'Effects of serelaxin in acute heart failure patients with renal impairment : results from RELAX-AHF', Clinical Research in Cardiology, vol. 105, no. 9, pp. 727-737. https://doi.org/10.1007/s00392-016-0979-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt12r8q9qn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/12r8q9qn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical research in cardiology : official journal of the German Cardiac Society, vol 105, iss 9","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt12r8q9qn","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/12r8q9qn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Research in Cardiology, vol 105, iss 9","raw_type":"article"},{"id":"pmh:oai:iris.unibs.it:11379/504405","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/504405","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/194117","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11768/194117","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/11321","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/11321","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publisher","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/11321","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/11321","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publisher","raw_type":"Article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/911ef2f8-6e36-4eaa-a605-4ad85d6557ab","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/911ef2f8-6e36-4eaa-a605-4ad85d6557ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Research in Cardiology, 105(9), 727 - 737. SPRINGER HEIDELBERG","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00392-016-0979-8","doi":"https://doi.org/10.1007/s00392-016-0979-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00392-016-0979-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00392-016-0979-8.pdf","source":{"id":"https://openalex.org/S81098524","display_name":"Clinical Research in Cardiology","issn_l":"1861-0684","issn":["1861-0684","1861-0692"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research in Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320315432","display_name":"Cytokinetics","ror":"https://ror.org/03tx9ss94"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"},{"id":"https://openalex.org/F4320333259","display_name":"Abbott Vascular","ror":"https://ror.org/05d67dc31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2311933341.pdf","grobid_xml":"https://content.openalex.org/works/W2311933341.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1508372417","https://openalex.org/W1511208491","https://openalex.org/W1573768413","https://openalex.org/W1592228396","https://openalex.org/W1964611256","https://openalex.org/W1979974003","https://openalex.org/W1981396509","https://openalex.org/W1981928687","https://openalex.org/W2001246657","https://openalex.org/W2016209925","https://openalex.org/W2017873721","https://openalex.org/W2026470245","https://openalex.org/W2033209427","https://openalex.org/W2033972839","https://openalex.org/W2034774373","https://openalex.org/W2053422287","https://openalex.org/W2054965274","https://openalex.org/W2055864845","https://openalex.org/W2072070134","https://openalex.org/W2072075701","https://openalex.org/W2077641457","https://openalex.org/W2078762775","https://openalex.org/W2083891358","https://openalex.org/W2093799426","https://openalex.org/W2096133307","https://openalex.org/W2105225153","https://openalex.org/W2107477990","https://openalex.org/W2117817860","https://openalex.org/W2118292976","https://openalex.org/W2118625269","https://openalex.org/W2126420462","https://openalex.org/W2126919203","https://openalex.org/W2133652794","https://openalex.org/W2133739113","https://openalex.org/W2150784397","https://openalex.org/W2152369470","https://openalex.org/W2160176956","https://openalex.org/W2160489474","https://openalex.org/W2163394653","https://openalex.org/W2298868338"],"related_works":["https://openalex.org/W4317435252","https://openalex.org/W2033972839","https://openalex.org/W2998077612","https://openalex.org/W4299122288","https://openalex.org/W1573768413","https://openalex.org/W2107477990","https://openalex.org/W2096133307","https://openalex.org/W2609921509","https://openalex.org/W2016209925","https://openalex.org/W2969766757"],"abstract_inverted_index":{"BACKGROUND:":[0],"Serelaxin":[1],"showed":[2],"beneficial":[3],"effects":[4],"on":[5],"clinical":[6],"outcome":[7],"and":[8,28,106,123,141,196],"trajectories":[9],"of":[10,32,41,121],"renal":[11,26,90,157,180,221],"markers":[12],"in":[13,116,163,199,204,210,213,218,229],"patients":[14,48,78,155,178,219],"with":[15,49,156,160,177,193,220],"acute":[16],"heart":[17],"failure.":[18],"We":[19],"aimed":[20],"to":[21,94,226],"study":[22],"the":[23,29,36,42,119,230],"interaction":[24,138,151],"between":[25],"function":[27],"treatment":[30,159],"effect":[31],"serelaxin.":[33],"METHODS:":[34],"In":[35,86,154],"current":[37],"post":[38],"hoc":[39],"analysis":[40],"RELAX-AHF":[43,214],"trial,":[44],"we":[45],"included":[46],"all":[47],"available":[50],"estimated":[51,71],"glomerular":[52],"filtration":[53],"rate":[54],"(eGFR)":[55],"at":[56],"baseline":[57,81,89],"(n":[58],"=":[59,139,152],"1132).":[60],"Renal":[61,189],"impairment":[62,91,181],"was":[63,92,126,191,215],"defined":[64],"as":[65],"an":[66],"eGFR":[67,82],"<60":[68,83],"ml/min/1.73":[69,84],"m(2)":[70],"by":[72],"creatinine.":[73],"RESULTS:":[74],"817":[75],"(72.2":[76],"%)":[77],"had":[79],"a":[80,95,164],"m(2).":[85],"placebo-treated":[87,200],"patients,":[88,118,201],"related":[93],"higher":[96,194],"180":[97],"day":[98],"cardiovascular":[99,122,195],"(HR":[100,109,129,170,182],"3.12,":[101],"95":[102,111,131,144,172,184],"%":[103,112,132,145,173,185],"CI":[104,113,133,146,174,186],"1.33-7.30)":[105],"all-cause":[107,124,167,197],"mortality":[108,125,168,198,212],"2.81,":[110],"1.34-5.89).":[114],"However,":[115],"serelaxin-treated":[117,205],"risk":[120],"less":[127],"pronounced":[128,166,217],"1.19,":[130],"0.54":[134],"-2.64;":[135],"p":[136,149],"for":[137,150],"0.106,":[140],"HR":[142],"1.15":[143],"0.56-2.34":[147],"respectively;":[148],"0.088).":[153],"impairment,":[158],"serelaxin":[161],"resulted":[162],"more":[165,216],"reduction":[169,209],"0.53,":[171],"0.34-0.83),":[175],"compared":[176],"without":[179],"1.30,":[183],"0.51-3.29).":[187],"CONCLUSION:":[188],"dysfunction":[190],"associated":[192],"but":[202],"not":[203],"patients.":[206],"The":[207],"observed":[208],"(cardiovascular)":[211],"dysfunction.":[222],"These":[223],"observations":[224],"need":[225],"be":[227],"confirmed":[228],"ongoing":[231],"RELAX-AHF-2":[232],"trial.":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}