{"id":"https://openalex.org/W231099894","doi":null,"title":"Regulation of sphingolipid synthesis in renal cells from normal subjects and familial hypercholesterolemic subjects","display_name":"Regulation of sphingolipid synthesis in renal cells from normal subjects and familial hypercholesterolemic subjects","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W231099894","mag":"231099894"},"language":"en","primary_location":{"id":"mag:231099894","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/7171353","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032644557","display_name":"Sumantra Chatterjee","orcid":"https://orcid.org/0000-0002-5076-1698","observed_orcids":["https://orcid.org/0000-0002-5076-1698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumantra Chatterjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5076-1698","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Clarke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Clarke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110177982","display_name":"Peter O. Kwiterovich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter O. Kwiterovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01855481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipid-biosynthesis","display_name":"sphingolipid biosynthesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9359999895095825},{"id":"https://openalex.org/keywords/renal-proximal-tubular-cells","display_name":"renal proximal tubular cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lactosylceramide","display_name":"lactosylceramide","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":1.0},{"id":"https://openalex.org/keywords/lysine-methylation","display_name":"lysine methylation","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.8897978663444519},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.8263311386108398},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7167031168937683},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5700176954269409},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5498603582382202},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.511277437210083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5069622993469238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4994995594024658},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.4980752468109131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48783615231513977},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.44228994846343994},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.42568475008010864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33631229400634766},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2662525773048401},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12484753131866455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09443414211273193},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:231099894","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/7171353","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1583865009","https://openalex.org/W1628167280","https://openalex.org/W2010722564","https://openalex.org/W2024459845","https://openalex.org/W2116328518","https://openalex.org/W2051289027","https://openalex.org/W1571265449","https://openalex.org/W2025974151","https://openalex.org/W104607401","https://openalex.org/W2605525678"],"abstract_inverted_index":{"The":[0,37,144],"authors":[1,145],"have":[2],"investigated":[3],"the":[4,48,64,92,98,121,148,161],"effects":[5],"of":[6,50,66,84,100,123,129,151,165,179],"lipoproteins":[7],"on":[8],"sphingolipid":[9,175],"metabolism":[10],"in":[11,139,153,169,173],"proximal":[12],"renal":[13,155],"tubular":[14],"cells":[15,41,109,140,156],"from":[16],"normal":[17,40,114,154],"subjects":[18,29],"and":[19,34,53,58,103,128,135,177],"low":[20],"density":[21],"lipoprotein":[22],"(LDL)":[23],"receptor-negative":[24],"homozygous":[25],"familial":[26],"hypercholesterolemic":[27],"(FH)":[28],"(TB,BA,DD,VH)":[30],"employing":[31],"(/sup":[32,35,51,54,67,101,104,124,130],"3/H)serine":[33,55,68,105,131],"3/H)glucose.":[36],"results":[38,172],"were:":[39],"-":[42,110],"1)":[43],"LDL":[44,79,93,116,142,162,166],"(25":[45],"..mu..g/ml)":[46,118],"decreased":[47],"incorporation":[49,65,99,122],"3/H)glucose":[52,102,125],"into":[56,69,106,126,132],"ceramide":[57],"LacCer":[59,127,134],"about":[60],"2-3":[61,137],"fold;":[62],"2)":[63],"sphingomyelin":[70,136],"was":[71],"also":[72],"reduced":[73],"2":[74],"fold":[75,138],"by":[76,81,91,160],"LDL;":[77],"3)":[78],"modified":[80],"reductive":[82],"methylation":[83],"lysine":[85],"residues":[86],"(which":[87],"is":[88],"not":[89,96],"recognized":[90],"receptor)":[94],"did":[95],"decrease":[97],"sphingolipids;":[107],"FH":[108,170],"In":[111],"contrast":[112],"to":[113],"cells,":[115,171],"(100":[117],"stimulated":[119],"both":[120],"ceramide,":[133],"lacking":[141],"receptors.":[143],"conclude":[146],"that":[147],"endogenous":[149],"synthesis":[150,176],"sphingolipids":[152],"may":[157],"be":[158],"regulated":[159],"receptor.":[163],"Lack":[164],"receptor,":[167],"as":[168],"increased":[174],"storage":[178],"LacCer.":[180]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}