{"id":"https://openalex.org/W2310580923","doi":"https://doi.org/10.1158/1940-6207.capr-15-0165","title":"Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques","display_name":"Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques","publication_year":2016,"publication_date":"2016-03-22","ids":{"openalex":"https://openalex.org/W2310580923","doi":"https://doi.org/10.1158/1940-6207.capr-15-0165","mag":"2310580923","pmid":"https://pubmed.ncbi.nlm.nih.gov/27006379","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932899"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.capr-15-0165","doi":"https://doi.org/10.1158/1940-6207.capr-15-0165","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-15-0165","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932899","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003264909","display_name":"Fitriya N. Dewi","orcid":"https://orcid.org/0000-0002-7908-7879","observed_orcids":["https://orcid.org/0000-0002-7908-7879"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["ID","US"],"is_corresponding":true,"raw_author_name":"Fitriya N. Dewi","raw_affiliation_strings":["1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","2Primate Research Center, Bogor Agricultural University, Bogor, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"2Primate Research Center, Bogor Agricultural University, Bogor, Indonesia","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065268260","display_name":"Charles E. Wood","orcid":"https://orcid.org/0000-0002-4648-6873","observed_orcids":["https://orcid.org/0000-0002-4648-6873"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Wood","raw_affiliation_strings":["1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028732744","display_name":"Cynthia J. Willson","orcid":"https://orcid.org/0000-0003-0942-3723","observed_orcids":["https://orcid.org/0000-0003-0942-3723"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia J. Willson","raw_affiliation_strings":["1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071573042","display_name":"Thomas C. Register","orcid":"https://orcid.org/0000-0002-4078-0166","observed_orcids":["https://orcid.org/0000-0002-4078-0166","https://orcid.org/0000-0002-1536-2288"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas C. Register","raw_affiliation_strings":["1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111792831","display_name":"Cynthia J. Lees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia J. Lees","raw_affiliation_strings":["1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028659405","display_name":"Timothy D. Howard","orcid":"https://orcid.org/0000-0003-2518-4902","observed_orcids":["https://orcid.org/0000-0003-2518-4902"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy D. Howard","raw_affiliation_strings":["3Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014633542","display_name":"Zhiqing Huang","orcid":"https://orcid.org/0000-0001-5092-9297","observed_orcids":["https://orcid.org/0000-0001-5092-9297"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiqing Huang","raw_affiliation_strings":["4Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090233781","display_name":"Susan K. Murphy","orcid":"https://orcid.org/0000-0001-8298-7272","observed_orcids":["https://orcid.org/0000-0001-8298-7272"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan K. Murphy","raw_affiliation_strings":["4Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006007842","display_name":"Janet Austin Tooze","orcid":"https://orcid.org/0000-0002-5160-0407","observed_orcids":["https://orcid.org/0000-0002-5160-0407"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet A. Tooze","raw_affiliation_strings":["5Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113170997","display_name":"Jeff W. Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff W. Chou","raw_affiliation_strings":["5Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024804165","display_name":"Lance David Miller","orcid":"https://orcid.org/0000-0003-3799-2528","observed_orcids":["https://orcid.org/0000-0003-3799-2528"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance D. Miller","raw_affiliation_strings":["6Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068860618","display_name":"J. Mark Cline","orcid":"https://orcid.org/0000-0003-4844-1238","observed_orcids":["https://orcid.org/0000-0003-4844-1238"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Mark Cline","raw_affiliation_strings":["1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5003264909"],"corresponding_institution_ids":["https://openalex.org/I21881038","https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":null,"apc_paid":null,"fwci":2.4254,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86541003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"5","first_page":"385","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-soy","display_name":"dietary soy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.8870000243186951},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.9670000076293945},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9179999828338623},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":1.0},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.925000011920929},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.9549999833106995},{"id":"https://openalex.org/keywords/menarche","display_name":"menarche","score":0.9890000224113464},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tff1","display_name":"TFF1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.8360000252723694},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.7350000143051147},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cynomolgus-macaques","display_name":"cynomolgus macaques","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7874506115913391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7615722417831421},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.726081132888794},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6701048016548157},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5774478912353516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5590885877609253},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5187609195709229},{"id":"https://openalex.org/C4258228","wikidata":"https://www.wikidata.org/wiki/Q492514","display_name":"Menarche","level":2,"score":0.45446059107780457},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.4142787456512451},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.31725770235061646},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2813136577606201},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18862739205360413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17018601298332214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0857880711555481},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05312967300415039}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030262","descriptor_name":"Soybean Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048789","descriptor_name":"Phytoestrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1940-6207.capr-15-0165","doi":"https://doi.org/10.1158/1940-6207.capr-15-0165","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-15-0165","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},{"id":"pmid:27006379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27006379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer prevention research (Philadelphia, Pa.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4932899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Prev Res (Phila)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4932899","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4932899","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Prev Res (Phila)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.6875,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1322238596","display_name":"SOY AND ESTROGEN INTERACTIONS IN THE BREAST","funder_award_id":"R01AT000639","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G9000328302","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000903615","display_name":"Laboratory Animal & Comparative Medicine Training","funder_award_id":"T32OD010957","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332689","display_name":"Wake Forest School of Medicine","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W914670989","https://openalex.org/W1827367692","https://openalex.org/W1967791820","https://openalex.org/W1967841068","https://openalex.org/W1970869473","https://openalex.org/W1976726102","https://openalex.org/W1976739900","https://openalex.org/W1982228042","https://openalex.org/W1990153910","https://openalex.org/W1993988720","https://openalex.org/W2000513465","https://openalex.org/W2006486496","https://openalex.org/W2008651555","https://openalex.org/W2010457001","https://openalex.org/W2015104432","https://openalex.org/W2017820158","https://openalex.org/W2021383412","https://openalex.org/W2028691872","https://openalex.org/W2031017817","https://openalex.org/W2034080965","https://openalex.org/W2039395322","https://openalex.org/W2042412547","https://openalex.org/W2045370334","https://openalex.org/W2045991021","https://openalex.org/W2046332265","https://openalex.org/W2048637593","https://openalex.org/W2048863570","https://openalex.org/W2057826198","https://openalex.org/W2059253709","https://openalex.org/W2062838782","https://openalex.org/W2077986050","https://openalex.org/W2081098333","https://openalex.org/W2096748132","https://openalex.org/W2103368550","https://openalex.org/W2103989098","https://openalex.org/W2107542271","https://openalex.org/W2113437172","https://openalex.org/W2118917928","https://openalex.org/W2121554827","https://openalex.org/W2128719333","https://openalex.org/W2130410032","https://openalex.org/W2134047883","https://openalex.org/W2138415423","https://openalex.org/W2139002248","https://openalex.org/W2142396486","https://openalex.org/W2148775403","https://openalex.org/W2152193434","https://openalex.org/W2166151601","https://openalex.org/W2168746754","https://openalex.org/W2170104026","https://openalex.org/W2170728568","https://openalex.org/W4242580111"],"related_works":["https://openalex.org/W2519723759","https://openalex.org/W1991866157","https://openalex.org/W2121554827","https://openalex.org/W2133197996","https://openalex.org/W2046332265","https://openalex.org/W2098042867","https://openalex.org/W1980765494","https://openalex.org/W2083905479","https://openalex.org/W1527063362","https://openalex.org/W2312880216"],"abstract_inverted_index":{"Endogenous":[0],"estrogens":[1,20],"influence":[2],"mammary":[3,40,228,241],"gland":[4,41,242],"development":[5],"during":[6,12,203],"puberty":[7],"and":[8,84,90,94,102,109,126,143,148,167,201,233,240],"breast":[9],"cancer":[10],"risk":[11],"adulthood.":[13],"Early-life":[14],"exposure":[15,226],"to":[16],"dietary":[17],"or":[18,58,187,192],"environmental":[19],"may":[21],"alter":[22,178],"estrogen-mediated":[23],"processes.":[24],"Soy":[25,135,174],"foods":[26],"contain":[27],"phytoestrogenic":[28],"isoflavones":[29],"(IF),":[30],"which":[31],"have":[32],"mixed":[33],"estrogen":[34,80,97],"agonist/antagonist":[35],"properties.":[36],"Here,":[37],"we":[38],"evaluated":[39],"responses":[42],"over":[43],"time":[44],"in":[45,171],"pubertal":[46,205],"female":[47],"cynomolgus":[48],"macaques":[49],"fed":[50],"diets":[51],"containing":[52,61],"either":[53],"casein/lactalbumin":[54],"(n":[55,69],"=":[56,70],"12)":[57],"soy":[59,225],"protein":[60],"a":[62,215],"human-equivalent":[63],"dose":[64],"of":[65,88,96,100,115,128,153,180],"120":[66],"mg":[67],"IF/day":[68],"17)":[71],"for":[72,146,190,218],"approximately":[73],"4.5":[74],"years":[75],"spanning":[76],"menarche.":[77,151],"We":[78],"assessed":[79],"receptor":[81,238],"(ER)":[82],"expression":[83,140,179,200,230],"activity,":[85],"promoter":[86,188],"methylation":[87,127,189],"ERs":[89,191],"their":[91],"downstream":[92],"targets,":[93],"markers":[95],"metabolism.":[98],"Expression":[99,152],"ER\u03b1":[101,104,147,229],"classical":[103],"response":[105],"genes":[106],"(TFF1,":[107],"PGR,":[108],"GREB1)":[110],"decreased":[111,168],"with":[112],"maturity,":[113],"independent":[114],"diet.":[116],"A":[117],"significant":[118],"inverse":[119],"correlation":[120],"was":[121,163],"observed":[122],"between":[123],"TFF1":[124,133],"mRNA":[125,145],"CpG":[129],"sites":[130],"within":[131],"the":[132,204,208],"promoter.":[134],"effects":[136,236],"included":[137],"lower":[138,144],"ER\u03b2":[139],"before":[141,165],"menarche":[142,166,170,232],"GREB1":[149],"after":[150,169,231],"GATA-3,":[154],"an":[155],"epithelial":[156],"differentiation":[157],"marker":[158],"that":[159,210],"regulates":[160],"ER\u03b1-mediated":[161],"transcription,":[162],"elevated":[164],"soy-fed":[172],"animals.":[173],"did":[175],"not":[176],"significantly":[177],"other":[181],"ER":[182,199],"activity":[183,202,239],"markers,":[184],"estrogen-metabolizing":[185],"enzymes,":[186],"ER-regulated":[193],"genes.":[194],"Our":[195],"results":[196],"demonstrate":[197],"greater":[198],"transition,":[206],"supporting":[207],"idea":[209],"this":[211],"life":[212],"stage":[213],"is":[214],"critical":[216],"window":[217],"phenotypic":[219],"modulation":[220],"by":[221],"estrogenic":[222],"compounds.":[223],"Pubertal":[224],"decreases":[227],"exerts":[234],"subtle":[235],"on":[237],"differentiation.":[243],"Cancer":[244],"Prev":[245],"Res;":[246],"9(5);":[247],"385-95.":[248],"\u00a92016":[249],"AACR.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}