{"id":"https://openalex.org/W231025824","doi":"https://doi.org/10.1023/a:1026404227624","title":"Transforming growth factor \u03b21 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells","display_name":"Transforming growth factor \u03b21 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W231025824","doi":"https://doi.org/10.1023/a:1026404227624","mag":"231025824","pmid":"https://pubmed.ncbi.nlm.nih.gov/10390144"},"language":"en","primary_location":{"id":"doi:10.1023/a:1026404227624","doi":"https://doi.org/10.1023/a:1026404227624","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1026404227624","pdf_url":null,"source":{"id":"https://openalex.org/S100674681","display_name":"Clinical & Experimental Metastasis","issn_l":"0262-0898","issn":["0262-0898","1573-7276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Metastasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022664740","display_name":"Wilhelmina Duivenvoorden","orcid":"https://orcid.org/0000-0003-3439-9163","observed_orcids":["https://orcid.org/0000-0003-3439-9163"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wilhelmina C.M. Duivenvoorden","raw_affiliation_strings":["Hamilton Regional Cancer Centre, McMaster University, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton Regional Cancer Centre, McMaster University, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522075","display_name":"Holger W. Hirte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Holger W. Hirte","raw_affiliation_strings":["Hamilton Regional Cancer Centre, McMaster University, Hamilton, Ontario, Canada","Hamilton Regional Cancer Centre, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton Regional Cancer Centre, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Hamilton Regional Cancer Centre, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100738658","display_name":"Gurmit Kaur Jagjit Singh","orcid":"https://orcid.org/0000-0002-3310-3706","observed_orcids":["https://orcid.org/0000-0002-3310-3706"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gurmit Singh","raw_affiliation_strings":["Hamilton Regional Cancer Centre, McMaster University, Hamilton, Ontario, Canada","Hamilton Regional Cancer Centre, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamilton Regional Cancer Centre, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Hamilton Regional Cancer Centre, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98251732"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":2.2655,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.88026634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"1","first_page":"33","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9890000224113464},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":1.0},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.925000011920929},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.626545786857605},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6248080730438232},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.545699954032898},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5443673729896545},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5128012299537659},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.48842209577560425},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.46141964197158813},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4449983537197113},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.44325560331344604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.415462464094162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39989563822746277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38217636942863464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35432225465774536},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3365901708602905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06873437762260437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05481913685798645}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1026404227624","doi":"https://doi.org/10.1023/a:1026404227624","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1026404227624","pdf_url":null,"source":{"id":"https://openalex.org/S100674681","display_name":"Clinical & Experimental Metastasis","issn_l":"0262-0898","issn":["0262-0898","1573-7276"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & Experimental Metastasis","raw_type":"journal-article"},{"id":"pmid:10390144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10390144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & experimental metastasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1419228847","https://openalex.org/W1484945382","https://openalex.org/W1495031987","https://openalex.org/W1500327513","https://openalex.org/W1505978562","https://openalex.org/W1514761907","https://openalex.org/W1525488707","https://openalex.org/W1546229037","https://openalex.org/W1546598465","https://openalex.org/W1550476632","https://openalex.org/W1593295279","https://openalex.org/W1595561754","https://openalex.org/W1600110256","https://openalex.org/W1626663099","https://openalex.org/W1808371613","https://openalex.org/W1882182790","https://openalex.org/W1904151540","https://openalex.org/W1921315347","https://openalex.org/W1963741882","https://openalex.org/W1969633015","https://openalex.org/W1969803272","https://openalex.org/W1978908854","https://openalex.org/W1980968239","https://openalex.org/W1991412644","https://openalex.org/W1995249913","https://openalex.org/W2007505920","https://openalex.org/W2010189280","https://openalex.org/W2017992936","https://openalex.org/W2021131224","https://openalex.org/W2021851067","https://openalex.org/W2028749490","https://openalex.org/W2047853476","https://openalex.org/W2049769334","https://openalex.org/W2059345500","https://openalex.org/W2072273255","https://openalex.org/W2073246990","https://openalex.org/W2073865988","https://openalex.org/W2075451472","https://openalex.org/W2079831464","https://openalex.org/W2095571954","https://openalex.org/W2107237937","https://openalex.org/W2129059044","https://openalex.org/W2153055943","https://openalex.org/W2167417167","https://openalex.org/W2168151332","https://openalex.org/W2255395527","https://openalex.org/W2290575488","https://openalex.org/W2339618925","https://openalex.org/W2397048910","https://openalex.org/W2419148924","https://openalex.org/W2466482004"],"related_works":["https://openalex.org/W2129851937","https://openalex.org/W4246702549","https://openalex.org/W2079932446","https://openalex.org/W2150026933","https://openalex.org/W2319002884","https://openalex.org/W2108725202","https://openalex.org/W2534152327","https://openalex.org/W2142562078","https://openalex.org/W7097498395","https://openalex.org/W2039688872"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}