{"id":"https://openalex.org/W2310145756","doi":null,"title":"The role of CCL5 (RANTES) in the immune response against Mycobacterium tuberculosis in the guinea pig","display_name":"The role of CCL5 (RANTES) in the immune response against Mycobacterium tuberculosis in the guinea pig","publication_year":2005,"publication_date":"2005-02-17","ids":{"openalex":"https://openalex.org/W2310145756","mag":"2310145756"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/1506","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/1506","pdf_url":"https://hdl.handle.net/1969.1/1506","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1969.1/1506","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014756239","display_name":"Troy Skwor","orcid":"https://orcid.org/0000-0002-1920-0788","observed_orcids":["https://orcid.org/0000-0002-1920-0788"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Troy Skwor","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1920-0788","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014756239"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":1.0},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bcg-vaccination","display_name":"BCG vaccination","score":0.7020000219345093},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.734000027179718},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.722000002861023},{"id":"https://openalex.org/keywords/tuberculous-pleurisy","display_name":"pleural tuberculosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pleural-effusion","display_name":"pleural effusion","score":0.902999997138977},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.640999972820282},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.6349999904632568},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6993153691291809},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6538572311401367},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.6032390594482422},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5750254988670349},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5334708094596863},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42474284768104553},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3981061577796936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3948606848716736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26908451318740845},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.16389071941375732},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07643431425094604},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.06696781516075134}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/1506","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/1506","pdf_url":"https://hdl.handle.net/1969.1/1506","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2310145756","doi":null,"is_oa":false,"landing_page_url":"http://oaktrust.library.tamu.edu/bitstream/1969.1/1506/1/etd-tamu-2004C-MDSC-Skwor.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/1506","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/1506","pdf_url":"https://hdl.handle.net/1969.1/1506","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2310145756.pdf","grobid_xml":"https://content.openalex.org/works/W2310145756.grobid-xml"},"referenced_works_count":213,"referenced_works":["https://openalex.org/W18521442","https://openalex.org/W45752262","https://openalex.org/W67368441","https://openalex.org/W98832283","https://openalex.org/W173754060","https://openalex.org/W204546040","https://openalex.org/W258113846","https://openalex.org/W963089722","https://openalex.org/W1480920464","https://openalex.org/W1481608537","https://openalex.org/W1485705546","https://openalex.org/W1489330398","https://openalex.org/W1506446583","https://openalex.org/W1506899062","https://openalex.org/W1507898351","https://openalex.org/W1508678300","https://openalex.org/W1509377507","https://openalex.org/W1510958293","https://openalex.org/W1529226217","https://openalex.org/W1532072084","https://openalex.org/W1535223882","https://openalex.org/W1538029215","https://openalex.org/W1540820582","https://openalex.org/W1544053969","https://openalex.org/W1547225947","https://openalex.org/W1554360333","https://openalex.org/W1557707473","https://openalex.org/W1560919596","https://openalex.org/W1562505691","https://openalex.org/W1563631631","https://openalex.org/W1568477959","https://openalex.org/W1604726444","https://openalex.org/W1638738262","https://openalex.org/W1651291190","https://openalex.org/W1666992496","https://openalex.org/W1671219548","https://openalex.org/W1814276120","https://openalex.org/W1837402067","https://openalex.org/W1847326477","https://openalex.org/W1886086121","https://openalex.org/W1896777078","https://openalex.org/W1925266814","https://openalex.org/W1928818161","https://openalex.org/W1934312184","https://openalex.org/W1935904707","https://openalex.org/W1941961496","https://openalex.org/W1959861774","https://openalex.org/W1966771241","https://openalex.org/W1966805747","https://openalex.org/W1967981628","https://openalex.org/W1973266914","https://openalex.org/W1977130245","https://openalex.org/W1977654213","https://openalex.org/W1980693461","https://openalex.org/W1986011878","https://openalex.org/W1989701896","https://openalex.org/W1996288593","https://openalex.org/W1996950781","https://openalex.org/W1998310721","https://openalex.org/W1999769934","https://openalex.org/W2001278078","https://openalex.org/W2002287426","https://openalex.org/W2005889674","https://openalex.org/W2006774887","https://openalex.org/W2006824931","https://openalex.org/W2010130350","https://openalex.org/W2011703114","https://openalex.org/W2012001629","https://openalex.org/W2013334014","https://openalex.org/W2014748042","https://openalex.org/W2014859732","https://openalex.org/W2017883909","https://openalex.org/W2018752560","https://openalex.org/W2023395434","https://openalex.org/W2025159406","https://openalex.org/W2025788012","https://openalex.org/W2027344845","https://openalex.org/W2028121061","https://openalex.org/W2028527058","https://openalex.org/W2029170529","https://openalex.org/W2029554086","https://openalex.org/W2029649408","https://openalex.org/W2030892259","https://openalex.org/W2032996592","https://openalex.org/W2033167205","https://openalex.org/W2035827257","https://openalex.org/W2037556753","https://openalex.org/W2038682607","https://openalex.org/W2049425687","https://openalex.org/W2049491684","https://openalex.org/W2050862002","https://openalex.org/W2051161288","https://openalex.org/W2052237637","https://openalex.org/W2052801683","https://openalex.org/W2054197076","https://openalex.org/W2054734697","https://openalex.org/W2057775435","https://openalex.org/W2057963035","https://openalex.org/W2059782047","https://openalex.org/W2060098138","https://openalex.org/W2061547700","https://openalex.org/W2061814831","https://openalex.org/W2063587295","https://openalex.org/W2065791817","https://openalex.org/W2066717330","https://openalex.org/W2070771684","https://openalex.org/W2070971742","https://openalex.org/W2075477269","https://openalex.org/W2076054894","https://openalex.org/W2078632334","https://openalex.org/W2081199994","https://openalex.org/W2082076486","https://openalex.org/W2084575557","https://openalex.org/W2087260579","https://openalex.org/W2087905758","https://openalex.org/W2089321956","https://openalex.org/W2090599143","https://openalex.org/W2091581294","https://openalex.org/W2093031111","https://openalex.org/W2094210266","https://openalex.org/W2095736339","https://openalex.org/W2096353975","https://openalex.org/W2097168105","https://openalex.org/W2097410798","https://openalex.org/W2098644908","https://openalex.org/W2099499236","https://openalex.org/W2099770366","https://openalex.org/W2102578857","https://openalex.org/W2102888433","https://openalex.org/W2104941073","https://openalex.org/W2105164715","https://openalex.org/W2105627161","https://openalex.org/W2107357004","https://openalex.org/W2107499811","https://openalex.org/W2108580966","https://openalex.org/W2108980066","https://openalex.org/W2109624542","https://openalex.org/W2110240848","https://openalex.org/W2111094647","https://openalex.org/W2112583269","https://openalex.org/W2113649904","https://openalex.org/W2114004413","https://openalex.org/W2114495529","https://openalex.org/W2115477132","https://openalex.org/W2115681469","https://openalex.org/W2115802786","https://openalex.org/W2117328868","https://openalex.org/W2118033114","https://openalex.org/W2119910602","https://openalex.org/W2120498547","https://openalex.org/W2122696789","https://openalex.org/W2122708604","https://openalex.org/W2123450457","https://openalex.org/W2124668320","https://openalex.org/W2126453774","https://openalex.org/W2129525334","https://openalex.org/W2129710335","https://openalex.org/W2129936527","https://openalex.org/W2130046741","https://openalex.org/W2130634758","https://openalex.org/W2132778553","https://openalex.org/W2132879755","https://openalex.org/W2133922377","https://openalex.org/W2134448305","https://openalex.org/W2134801546","https://openalex.org/W2135577920","https://openalex.org/W2136827191","https://openalex.org/W2137806615","https://openalex.org/W2137847849","https://openalex.org/W2138432086","https://openalex.org/W2139140126","https://openalex.org/W2139795951","https://openalex.org/W2140883547","https://openalex.org/W2141912213","https://openalex.org/W2142021677","https://openalex.org/W2146014199","https://openalex.org/W2148104823","https://openalex.org/W2148320237","https://openalex.org/W2151026535","https://openalex.org/W2151612737","https://openalex.org/W2151648526","https://openalex.org/W2152937186","https://openalex.org/W2155050002","https://openalex.org/W2156132467","https://openalex.org/W2157737997","https://openalex.org/W2158113015","https://openalex.org/W2159586303","https://openalex.org/W2161965432","https://openalex.org/W2162146381","https://openalex.org/W2162186771","https://openalex.org/W2162397728","https://openalex.org/W2164350084","https://openalex.org/W2168174741","https://openalex.org/W2168384341","https://openalex.org/W2171564346","https://openalex.org/W2172009888","https://openalex.org/W2182298680","https://openalex.org/W2188890963","https://openalex.org/W2191654227","https://openalex.org/W2221153673","https://openalex.org/W2237403372","https://openalex.org/W2242935671","https://openalex.org/W2245063338","https://openalex.org/W2329624450","https://openalex.org/W2342908712","https://openalex.org/W2399895799","https://openalex.org/W2403619870","https://openalex.org/W2414297626","https://openalex.org/W2429402849","https://openalex.org/W2472648115","https://openalex.org/W4312600660","https://openalex.org/W4312991605","https://openalex.org/W4313377128"],"related_works":["https://openalex.org/W1963602064","https://openalex.org/W2026954989","https://openalex.org/W2116880858","https://openalex.org/W1974922643","https://openalex.org/W2131436565","https://openalex.org/W2124668320","https://openalex.org/W2002988406","https://openalex.org/W2114495529","https://openalex.org/W2072633085","https://openalex.org/W2132778553"],"abstract_inverted_index":{"Tuberculosis":[0],"is":[1],"the":[2,31,37,120],"second":[3],"leading":[4],"cause":[5],"of":[6,17,30,33,57,74,128,200,216,276],"morbidity":[7],"and":[8,48,52,68,90,95,109,113,133,145,162,177,190,219,232,239,253,279,286],"mortality":[9],"worldwide":[10],"due":[11],"to":[12,87,152,157,167,193,202],"an":[13,154,295],"infectious":[14],"disease.":[15],"Development":[16],"a":[18,27,62],"new":[19],"tuberculosis":[20,140,184,204,305],"(TB)":[21],"vaccine":[22],"would":[23],"be":[24],"facilitated":[25],"by":[26,36,81,260],"better":[28],"understanding":[29],"mechanisms":[32],"protection":[34],"induced":[35,249],"current":[38],"TB":[39],"vaccine,":[40],"Mycobacterium":[41],"bovis":[42],"BCG.":[43],"Recombinant":[44],"guinea":[45,175,247],"pig":[46],"(rgp)CCL5":[47],"anti-rgpCCL5":[49,76,149,259],"were":[50,221,241],"developed":[51],"characterized.":[53],"The":[54,72,126,198],"biological":[55],"activity":[56],"rgpCCL5":[58,257],"was":[59,79,85,99,141,150,165,207],"determined":[60],"in":[61,93,119,124,135,143,146,179,205,209,236,246,270,282,300],"chemotaxis":[63],"assay":[64,156],"using":[65,101],"T":[66],"lymphocytes":[67],"pleural":[69,211,237,283],"exudate":[70],"cells.":[71],"specificity":[73],"rabbit":[75],"polyclonal":[77],"antibody":[78],"confirmed":[80],"Western":[82],"blot.":[83],"RgpCCL5":[84,104],"used":[86,151,166],"stimulate":[88],"alveolar":[89],"peritoneal":[91],"macrophages":[92],"vitro.":[94],"cytokine/chemokine":[96,233],"gene":[97],"expression":[98,132],"evaluated":[100],"real-time":[102,163],"PCR.":[103],"stimulated":[105],"TNF\u03b1,":[106,278],"IL-1\u03b2,":[107],"CCL2,":[108],"CXCL8":[110],"mRNA":[111,189,218,234,281],"\\nexpression":[112],"TNF\u03b1":[114],"protein":[115,160,191,220],"production":[116,134],"(as":[117],"assessed":[118],"L929":[121],"cell":[122],"bioassay)":[123],"macrophages.":[125],"effect":[127],"BCG-vaccination":[129],"on":[130,243],"CCL5":[131,169,217,268,280],"leukocytes":[136,302],"infected":[137,178],"with":[138,181,250,255],"M.":[139,183,203,304],"examined":[142],"vitro":[144,180],"vivo.":[147],"Polyclonal":[148],"develop":[153],"ELISA":[155],"quantify":[158],"gpCCL5":[159,188,201,299],"levels,":[161],"PCR":[164],"detect":[168],"mRNA.":[170],"Leukocytes":[171],"isolated":[172],"from":[173,195],"BCG-vaccinated":[174],"pigs":[176,248],"virulent":[182],"demonstrated":[185],"significantly":[186],"elevated":[187],"compared":[192],"cells":[194,238],"naive":[196],"animals.":[197],"response":[199],"vivo":[206],"studied":[208],"tuberculous":[210,251],"effusions,":[212],"where":[213],"peak":[214],"levels":[215,235,275],"reached":[222],"at":[223],"day":[224,244],"4":[225,245],"post-induction.":[226],"Disease":[227],"severity,":[228],"cellular":[229],"differentiation,":[230],"histology,":[231],"granulomas":[240],"analyzed":[242],"pleurisy":[252],"treated":[254],"either":[256],"or":[258],"direct":[261],"intra-pleural":[262],"injection.":[263],"In":[264],"these":[265,292],"studies,":[266],"neutralizing":[267],"resulted":[269],"reduced":[271,287],"macrophage":[272],"accumulation,":[273],"diminished":[274],"IFN\u03b3,":[277],"effusion":[284],"cells,":[285],"spontaneous":[288],"lymphocyte":[289],"proliferation.":[290],"Together":[291],"studies":[293],"suggest":[294],"important":[296],"role":[297],"for":[298],"activating":[301],"during":[303],"infection.":[306]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}