{"id":"https://openalex.org/W2310039153","doi":"https://doi.org/10.1158/1538-7445.chromepi15-pr04","title":"Abstract PR04: Targeting super-enhancer driven oncogene transcription through cyclin-dependent kinase inhibitors","display_name":"Abstract PR04: Targeting super-enhancer driven oncogene transcription through cyclin-dependent kinase inhibitors","publication_year":2016,"publication_date":"2016-01-14","ids":{"openalex":"https://openalex.org/W2310039153","doi":"https://doi.org/10.1158/1538-7445.chromepi15-pr04","mag":"2310039153"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.chromepi15-pr04","doi":"https://doi.org/10.1158/1538-7445.chromepi15-pr04","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.chromepi15-pr04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069634592","display_name":"Ma\u0142gorzata Krajewska","orcid":"https://orcid.org/0000-0002-2243-5924","observed_orcids":["https://orcid.org/0000-0002-2243-5924"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malgorzata Krajewska","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107174679","display_name":"Nathan F. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan F. Moore","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014982944","display_name":"Edmond Chipumuro","orcid":"https://orcid.org/0009-0009-1640-1718","observed_orcids":["https://orcid.org/0009-0009-1640-1718"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmond Chipumuro","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103190532","display_name":"Tinghu Zhang","orcid":"https://orcid.org/0000-0003-1028-8020","observed_orcids":["https://orcid.org/0000-0003-1028-8020"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tinghu Zhang","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019424374","display_name":"Eugenio Marco","orcid":"https://orcid.org/0000-0002-3675-263X","observed_orcids":["https://orcid.org/0000-0002-3675-263X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugenio Marco","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068507476","display_name":"Clark M. Hatheway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clark Hatheway","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104256607","display_name":"Bandana Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bandana Sharma","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076667777","display_name":"Nicholas P. Kwiatkowski","orcid":"https://orcid.org/0000-0002-2092-4185","observed_orcids":["https://orcid.org/0000-0002-2092-4185"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Kwiatkowski","raw_affiliation_strings":["2Whitehead Institute for Biomedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Whitehead Institute for Biomedical Research, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038587862","display_name":"Guo\u2010Cheng Yuan","orcid":"https://orcid.org/0000-0002-2283-4714","observed_orcids":["https://orcid.org/0000-0002-2283-4714"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guo-Cheng Yuan","raw_affiliation_strings":["2Whitehead Institute for Biomedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Whitehead Institute for Biomedical Research, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112460504","display_name":"Richard A. Young","orcid":"https://orcid.org/0000-0001-8855-8647","observed_orcids":["https://orcid.org/0000-0001-8855-8647"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Young","raw_affiliation_strings":["2Whitehead Institute for Biomedical Research, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Whitehead Institute for Biomedical Research, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022352605","display_name":"Nathanael S. Gray","orcid":"https://orcid.org/0000-0001-5354-7403","observed_orcids":["https://orcid.org/0000-0001-5354-7403"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathanael S. Gray","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002000126","display_name":"Rani E. George","orcid":"https://orcid.org/0000-0003-4206-1779","observed_orcids":["https://orcid.org/0000-0003-4206-1779"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rani E. George","raw_affiliation_strings":["1Dana-Farber Cancer Institute, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Dana-Farber Cancer Institute, Boston, MA,","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"2_Supplement","first_page":"PR04","last_page":"PR04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.399399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.399399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.1720000058412552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.15940000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/super-enhancers","display_name":"super-enhancers","score":0.7369999885559082},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cdk7","display_name":"CDK7","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cdk12","display_name":"CDK12","score":0.9129999876022339},{"id":"https://openalex.org/keywords/thz1","display_name":"THZ1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/oncogenic-transcription","display_name":"oncogenic transcription","score":0.5730000138282776},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.8050000071525574},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/rna-processing","display_name":"RNA processing","score":0.9100000262260437},{"id":"https://openalex.org/keywords/transcriptional-amplification","display_name":"transcriptional amplification","score":0.6980000138282776},{"id":"https://openalex.org/keywords/covalent-kinase-inhibitors","display_name":"covalent kinase inhibitors","score":0.6600000262260437},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.793874979019165},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.6978757977485657},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6448613405227661},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6071391701698303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5897982716560364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48962122201919556},{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.4719212055206299},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.456400066614151},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42651426792144775},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42193490266799927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41835179924964905},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3172105848789215},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.30435436964035034},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.2928731143474579},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.23185482621192932},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.175933837890625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1615617871284485},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.15941613912582397},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.chromepi15-pr04","doi":"https://doi.org/10.1158/1538-7445.chromepi15-pr04","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.chromepi15-pr04","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2408643602","https://openalex.org/W2170846478","https://openalex.org/W2298401663","https://openalex.org/W2092758083","https://openalex.org/W4253781941","https://openalex.org/W2338340854","https://openalex.org/W2280725868","https://openalex.org/W4409944430","https://openalex.org/W4210455850","https://openalex.org/W2740622331"],"abstract_inverted_index":{"Abstract":[0],"Cyclin-dependent":[1],"kinases":[2],"(CDKs)":[3],"with":[4,128,207],"primary":[5],"roles":[6],"in":[7,16,44,51,75,94,110,178,182,303],"transcription":[8,25,52,76,152,201,236,247,286],"regulation":[9],"are":[10],"emerging":[11],"as":[12,68,159,250],"tractable":[13],"therapeutic":[14],"targets":[15],"cancers":[17,243],"driven":[18,98,244,284],"by":[19,54,99,230,245],"the":[20,32,56,235,240,295],"aberrant":[21],"expression":[22],"of":[23,37,60,114,131,140,166,199,210,218,234,242,294],"oncogenic":[24,38,246],"factors.":[26],"Our":[27],"goal":[28],"is":[29],"to":[30,106,137,155,189,196],"disrupt":[31],"myriad":[33],"and":[34,65,78,92,149,162,214,301],"pleomorphic":[35],"features":[36],"MYC":[39],"through":[40,287],"inhibiting":[41],"CDKs":[42],"involved":[43],"its":[45],"transcriptional":[46,133,227],"amplifier":[47],"role.":[48],"CDK7":[49,85],"participates":[50],"initiation":[53],"phosphorylating":[55],"carboxy-terminal":[57],"domain":[58],"(CTD)":[59],"RNA":[61,79,211],"polymerase":[62],"(Pol)":[63],"II":[64,142],"also":[66],"functions":[67,74],"a":[69,82,111,170,215],"CDK-activating":[70],"kinase,":[71],"while":[72],"CDK12":[73,167],"elongation":[77],"processing.":[80],"Using":[81],"novel":[83],"covalent":[84],"inhibitor,":[86,175],"THZ1,":[87],"we":[88],"demonstrated":[89],"striking":[90],"activity":[91,168,181],"selectivity":[93],"neuroblastoma":[95],"(NB)":[96],"cells":[97],"high":[100],"MYCN":[101,148],"expression.":[102],"This":[103],"response":[104],"translated":[105],"significant":[107,197],"tumor":[108],"regression":[109],"mouse":[112],"model":[113],"high-risk":[115],"NB,":[116],"without":[117],"introducing":[118],"discernible":[119],"toxicity.":[120],"We":[121],"determined":[122],"that":[123,226],"this":[124],"effect":[125],"was":[126,205],"associated":[127,206],"global":[129,200],"inhibition":[130,165,198],"MYCN-dependent":[132],"amplification.":[134],"THZ1":[135],"led":[136],"preferential":[138,208],"downregulation":[139,209],"Pol":[141],"occupancy":[143],"at":[144],"super-enhancer-associated":[145],"genes,":[146],"including":[147],"other":[150],"master":[151],"factors":[153,213,248],"critical":[154],"neuronal":[156],"development":[157],"such":[158,249],"PHOX2B,":[160],"GATA2,":[161],"DBH.":[163],"Similarly,":[164],"using":[169],"novel,":[171],"first-in-class":[172],"small":[173],"molecule":[174],"THZ-5-31-1,":[176],"resulted":[177],"potent":[179],"antitumor":[180],"MYCN-overexpressing":[183],"NB":[184],"cells.":[185],"THZ-5-31-1":[186],"doses":[187],"sufficient":[188],"induce":[190],"PARP":[191],"cleavage":[192],"did":[193],"not":[194],"lead":[195],"elongation.":[202],"Rather,":[203],"cytotoxicity":[204],"processing":[212],"higher":[216],"percentage":[217],"immature":[219],"mRNA":[220],"transcripts.":[221],"Together,":[222],"these":[223],"results":[224],"suggest":[225],"CDK":[228],"inhibitors,":[229],"affecting":[231],"different":[232],"aspects":[233],"machinery,":[237],"may":[238],"inhibit":[239],"growth":[241],"MYC.":[251],"Citation":[252],"Format:":[253],"Malgorzata":[254],"Krajewska,":[255],"Nathan":[256],"F.":[257],"Moore,":[258],"Edmond":[259],"Chipumuro,":[260],"Tinghu":[261],"Zhang,":[262],"Eugenio":[263],"Marco,":[264],"Clark":[265],"Hatheway,":[266],"Bandana":[267],"Sharma,":[268],"Nicholas":[269],"Kwiatkowski,":[270],"Guo-Cheng":[271],"Yuan,":[272],"Richard":[273],"A.":[274],"Young,":[275],"Nathanael":[276],"S.":[277],"Gray,":[278],"Rani":[279],"E.":[280],"George.":[281],"Targeting":[282],"super-enhancer":[283],"oncogene":[285],"cyclin-dependent":[288],"kinase":[289],"inhibitors.":[290],"[abstract].":[291],"In:":[292],"Proceedings":[293],"AACR":[296],"Special":[297],"Conference":[298],"on":[299],"Chromatin":[300],"Epigenetics":[302],"Cancer;":[304],"Sep":[305],"24-27,":[306],"2015;":[307],"Atlanta,":[308],"GA.":[309],"Philadelphia":[310],"(PA):":[311],"AACR;":[312],"Cancer":[313],"Res":[314],"2016;76(2":[315],"Suppl):Abstract":[316],"nr":[317],"PR04.":[318]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
