{"id":"https://openalex.org/W2310035752","doi":"https://doi.org/10.1172/jci86801","title":"Cancer\u2019s got nerve: Schwann cells drive perineural invasion","display_name":"Cancer\u2019s got nerve: Schwann cells drive perineural invasion","publication_year":2016,"publication_date":"2016-03-20","ids":{"openalex":"https://openalex.org/W2310035752","doi":"https://doi.org/10.1172/jci86801","mag":"2310035752","pmid":"https://pubmed.ncbi.nlm.nih.gov/26999601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4811122"},"language":"en","primary_location":{"id":"doi:10.1172/jci86801","doi":"https://doi.org/10.1172/jci86801","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci86801","pdf_url":"http://www.jci.org/articles/view/86801/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/86801/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063733765","display_name":"Salma H. Azam","orcid":"https://orcid.org/0000-0003-1861-0475","observed_orcids":["https://orcid.org/0000-0003-1861-0475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salma H. Azam","raw_affiliation_strings":["Curriculum in Genetics and Molecular Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curriculum in Genetics and Molecular Biology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017773172","display_name":"Chad Victor Pecot","orcid":"https://orcid.org/0000-0002-5250-2999","observed_orcids":["https://orcid.org/0000-0002-5250-2999"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad V. Pecot","raw_affiliation_strings":["Department of Medicine,","Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","Lineberger Comprehensive Cancer Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017773172"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.2927,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86545614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"126","issue":"4","first_page":"1242","last_page":"1244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.7584903240203857},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.6594987511634827},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6087344288825989},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5544416904449463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45867830514907837},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4372020363807678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43188297748565674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35604381561279297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34978997707366943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14090684056282043}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019002","descriptor_name":"CD56 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci86801","doi":"https://doi.org/10.1172/jci86801","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci86801","pdf_url":"http://www.jci.org/articles/view/86801/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4811122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4811122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:26999601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26999601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci86801","doi":"https://doi.org/10.1172/jci86801","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci86801","pdf_url":"http://www.jci.org/articles/view/86801/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3757727673","display_name":"NRSA in Genetics","funder_award_id":"T32GM007092","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G866671421","display_name":null,"funder_award_id":"GM007092","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332524","display_name":"Gillings School of Public Health","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2310035752.pdf","grobid_xml":"https://content.openalex.org/works/W2310035752.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1532654778","https://openalex.org/W1557220830","https://openalex.org/W1964239599","https://openalex.org/W1966192867","https://openalex.org/W1972111650","https://openalex.org/W2001052726","https://openalex.org/W2005067021","https://openalex.org/W2014334618","https://openalex.org/W2017962781","https://openalex.org/W2018543404","https://openalex.org/W2022121781","https://openalex.org/W2024523695","https://openalex.org/W2034401564","https://openalex.org/W2049959255","https://openalex.org/W2050019055","https://openalex.org/W2077247278","https://openalex.org/W2083977403","https://openalex.org/W2091562888","https://openalex.org/W2095612053","https://openalex.org/W2113048638","https://openalex.org/W2113774043","https://openalex.org/W2151356556","https://openalex.org/W2162900557","https://openalex.org/W2306715392","https://openalex.org/W2409142170","https://openalex.org/W4236458467"],"related_works":["https://openalex.org/W2306715392","https://openalex.org/W4212877747","https://openalex.org/W7024378806","https://openalex.org/W2502092975","https://openalex.org/W2915348578","https://openalex.org/W2324753312","https://openalex.org/W4409633431","https://openalex.org/W4302275376","https://openalex.org/W2120421863","https://openalex.org/W4312631292"],"abstract_inverted_index":{"The":[0,96],"invasion":[1,22],"of":[2,29,40,51,85,90,98,110],"cancer":[3,13,65,68,91],"cells":[4,63,66,92],"around":[5],"and":[6,15,55,64,72,107],"into":[7,104],"nerves":[8],"is":[9,33],"associated":[10],"with":[11],"increased":[12],"aggression":[14],"poor":[16],"patient":[17],"outcome.":[18],"As":[19],"this":[20,49,86,99],"perineural":[21,94,111],"increases":[23],"disease":[24],"severity,":[25],"a":[26],"better":[27],"understanding":[28],"how":[30],"the":[31,38,52,105],"process":[32],"regulated":[34],"may":[35],"help":[36],"in":[37,46,93],"development":[39],"therapeutics":[41],"to":[42],"target":[43],"neuronal":[44],"involvement":[45],"cancer.":[47],"In":[48],"issue":[50],"JCI,":[53],"Deborde":[54],"colleagues":[56],"show":[57],"that":[58],"direct":[59],"contact":[60],"between":[61],"Schwann":[62,87],"promotes":[67],"cell":[69],"dissociation,":[70],"migration,":[71],"invasion.":[73,95,112],"Moreover,":[74],"their":[75],"data":[76],"specifically":[77],"suggest":[78],"NCAM1":[79],"as":[80],"an":[81],"important":[82],"molecular":[83,108],"mediator":[84],"cell-directed":[88],"regulation":[89],"results":[97],"study":[100],"provide":[101],"new":[102],"insight":[103],"cellular":[106],"mechanisms":[109]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
