{"id":"https://openalex.org/W2309398802","doi":null,"title":"Specific identification of intracellular immunoglobulin in paraffin sections of multiple myeloma and macroglobulinemia using an immunoperoxidase technique.","display_name":"Specific identification of intracellular immunoglobulin in paraffin sections of multiple myeloma and macroglobulinemia using an immunoperoxidase technique.","publication_year":1977,"publication_date":"1977-04-01","ids":{"openalex":"https://openalex.org/W2309398802","mag":"2309398802","pmid":"https://pubmed.ncbi.nlm.nih.gov/403769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032074"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2032074","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032074","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032074","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112148042","display_name":"Geraldine S. Pinkus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G S Pinkus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083115147","display_name":"JONATHAN W. SAID","orcid":"https://orcid.org/0000-0001-9474-2563","observed_orcids":["https://orcid.org/0000-0001-9474-2563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J W Said","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.2574,"has_fulltext":false,"cited_by_count":288,"citation_normalized_percentile":{"value":0.98894822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"87","issue":"1","first_page":"47","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-immunoglobulin","display_name":"intracellular immunoglobulin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/macroglobulinemia","display_name":"macroglobulinemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/paraffin-embedded-tissue","display_name":"paraffin-embedded tissue","score":0.8539999723434448},{"id":"https://openalex.org/keywords/m-protein","display_name":"M protein","score":0.8399999737739563},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lymphoplasmacytic-cells","display_name":"lymphoplasmacytic cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/bone-marrow-biopsy","display_name":"bone marrow biopsy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/formalin-fixed-tissue","display_name":"formalin-fixed tissue","score":0.5490000247955322},{"id":"https://openalex.org/keywords/decalcification","display_name":"decalcification","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C128102431","wikidata":"https://www.wikidata.org/wiki/Q6005550","display_name":"Immunoperoxidase","level":4,"score":0.9154345989227295},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.7613590359687805},{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.6725835204124451},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6432113647460938},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.613955557346344},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.508319079875946},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.49575552344322205},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.4569757878780365},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.4359320104122162},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4293590486049652},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4118041694164276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4049653708934784},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3464685380458832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.315341979265213},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.29124006628990173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26432520151138306},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.10167357325553894}],"mesh":[{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2032074","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032074","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:403769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/403769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:2309398802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/403769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2032074","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032074","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W82759262","https://openalex.org/W1891685124","https://openalex.org/W1983409664","https://openalex.org/W2006387884","https://openalex.org/W2032552530","https://openalex.org/W2036089223","https://openalex.org/W2075183241","https://openalex.org/W2092733095","https://openalex.org/W2111039706","https://openalex.org/W2135184231","https://openalex.org/W2157086829","https://openalex.org/W2417716798"],"related_works":["https://openalex.org/W2417716798","https://openalex.org/W1970202940","https://openalex.org/W2315686769","https://openalex.org/W2407384165","https://openalex.org/W2398831927","https://openalex.org/W2412176331","https://openalex.org/W7098762940","https://openalex.org/W2318811741","https://openalex.org/W2075183241","https://openalex.org/W2523101471"],"abstract_inverted_index":{"Paraffin-embedded":[0],"tissues":[1,63],"of":[2,5,11,23,100],"47":[3],"cases":[4,10],"multiple":[6],"myeloma":[7],"and":[8,55,61,91,109],"4":[9],"macroglobulinemia":[12],"were":[13,43],"studied":[14],"by":[15],"the":[16,39,79,85,92],"immunoperoxidase":[17,104],"indirect":[18],"sandwich":[19],"technique":[20,105],"for":[21,112],"identification":[22],"intracytoplasmic":[24],"immunoglobulin.":[25],"Specific":[26],"immunoglobulin":[27,81,94,115],"with":[28],"a":[29,107],"single":[30],"heavy":[31],"and/or":[32],"light":[33],"chain":[34],"was":[35,76],"readily":[36],"detected":[37,82],"in":[38,71,84,96,116],"neoplastic":[40],"cells.":[41],"Studies":[42],"performed":[44],"on":[45,62],"iliac":[46],"crest":[47],"bone":[48],"marrow":[49],"biopsies":[50],"which":[51,67],"had":[52,68],"been":[53,69],"fixed":[54,70],"decalcified":[56],"using":[57],"Zenker's-acetic":[58],"acid":[59],"solution":[60],"from":[64],"various":[65],"sites":[66],"formalin.":[72],"An":[73],"excellent":[74],"correlation":[75],"obtained":[77],"between":[78],"specific":[80,110],"intracellularly":[83],"plasma":[86],"cells":[87,90],"or":[88,98],"lymphoplasmacytic":[89],"monoclonal":[93],"found":[95],"serum":[97],"urine":[99],"these":[101],"cases.":[102],"The":[103],"represents":[106],"sensitive":[108],"method":[111],"identifying":[113],"intracellular":[114],"paraffin-embedded":[117],"tissues.":[118]},"counts_by_year":[{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":130},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}