{"id":"https://openalex.org/W2309182002","doi":"https://doi.org/10.1042/cs0650143","title":"The Effects of Cardioselective and Non-Selective \u03b2-Adrenoceptor Blockade on the Hypokalaemic and Cardiovascular Responses to Adrenomedullary Hormones in Man","display_name":"The Effects of Cardioselective and Non-Selective \u03b2-Adrenoceptor Blockade on the Hypokalaemic and Cardiovascular Responses to Adrenomedullary Hormones in Man","publication_year":1983,"publication_date":"1983-08-01","ids":{"openalex":"https://openalex.org/W2309182002","doi":"https://doi.org/10.1042/cs0650143","mag":"2309182002","pmid":"https://pubmed.ncbi.nlm.nih.gov/6861446"},"language":"en","primary_location":{"id":"doi:10.1042/cs0650143","doi":"https://doi.org/10.1042/cs0650143","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0650143","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000572520","display_name":"Allan D. Struthers","orcid":"https://orcid.org/0000-0002-2926-2528","observed_orcids":["https://orcid.org/0000-0002-2926-2528"]},"institutions":[{"id":"https://openalex.org/I2801766584","display_name":"Monklands Hospital","ror":"https://ror.org/05m64xs77","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801443577","https://openalex.org/I2801766584"]},{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. D. Struthers","raw_affiliation_strings":["Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","institution_ids":["https://openalex.org/I2801766584"]},{"raw_affiliation_string":"University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K","institution_ids":["https://openalex.org/I2802797558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109983392","display_name":"John L. Reid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766584","display_name":"Monklands Hospital","ror":"https://ror.org/05m64xs77","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801443577","https://openalex.org/I2801766584"]},{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. L. Reid","raw_affiliation_strings":["Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","institution_ids":["https://openalex.org/I2801766584"]},{"raw_affiliation_string":"University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K","institution_ids":["https://openalex.org/I2802797558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021570855","display_name":"R. Whitesmith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766584","display_name":"Monklands Hospital","ror":"https://ror.org/05m64xs77","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801443577","https://openalex.org/I2801766584"]},{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Whitesmith","raw_affiliation_strings":["Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","institution_ids":["https://openalex.org/I2801766584"]},{"raw_affiliation_string":"University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K","institution_ids":["https://openalex.org/I2802797558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000948715","display_name":"J C Rodger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766584","display_name":"Monklands Hospital","ror":"https://ror.org/05m64xs77","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801443577","https://openalex.org/I2801766584"]},{"id":"https://openalex.org/I2802797558","display_name":"Stobhill Hospital","ror":"https://ror.org/04pc31859","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2802797558"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. C. Rodger","raw_affiliation_strings":["Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Monklands General Hospital, Airdrie, Scotland, U.K","institution_ids":["https://openalex.org/I2801766584"]},{"raw_affiliation_string":"University Department of Materia Medica and Department of Biochemistry, Stobhill General Hospital, Glasgow, Scotland, U.K","institution_ids":["https://openalex.org/I2802797558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.5904,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.98678213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"65","issue":"2","first_page":"143","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.2549000084400177,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.20749999582767487,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-blockade","display_name":"beta-adrenergic blockade","score":0.8820000290870667},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.9399999976158142},{"id":"https://openalex.org/keywords/timolol","display_name":"timolol","score":1.0},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.9049999713897705},{"id":"https://openalex.org/keywords/serum-potassium","display_name":"serum potassium","score":0.8429999947547913},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cardiovascular-response","display_name":"cardiovascular response","score":0.550000011920929},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.6470000147819519},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8370000123977661},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.9315087795257568},{"id":"https://openalex.org/C2778073030","wikidata":"https://www.wikidata.org/wiki/Q413994","display_name":"Timolol","level":3,"score":0.7457185983657837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6387925744056702},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6068311333656311},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5927382111549377},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.583041787147522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4843045771121979},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.4672529399394989},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.45286720991134644},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.44141480326652527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36752384901046753},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.08312037587165833},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.05769181251525879},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007008","descriptor_name":"Hypokalemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013999","descriptor_name":"Timolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/cs0650143","doi":"https://doi.org/10.1042/cs0650143","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0650143","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:6861446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6861446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Clinical Trial"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/18cb2d58-8752-4e07-b993-88b54983b371","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/18cb2d58-8752-4e07-b993-88b54983b371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Struthers, A D, Reid, J L, Whitesmith, R & Rodger, J C 1983, 'The effects of cardioselective and non-selective beta-adrenoceptor blockade on the hypokalaemic and cardiovascular responses to adrenomedullary hormones in man', Clinical Science, vol. 65, no. 2, pp. 143-7.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1966946242","https://openalex.org/W1991866498","https://openalex.org/W2031109036","https://openalex.org/W2045436525","https://openalex.org/W2046785549","https://openalex.org/W2053385870","https://openalex.org/W2054992237","https://openalex.org/W2074095576","https://openalex.org/W2074422660","https://openalex.org/W2092771620","https://openalex.org/W2093186992","https://openalex.org/W2094726749","https://openalex.org/W2097530566","https://openalex.org/W2142556879","https://openalex.org/W2270459591","https://openalex.org/W2284531888","https://openalex.org/W2467224354","https://openalex.org/W2891899192"],"related_works":["https://openalex.org/W2059014716","https://openalex.org/W2102266932","https://openalex.org/W2163045107","https://openalex.org/W2002556471","https://openalex.org/W2920841110","https://openalex.org/W2009477977","https://openalex.org/W2059312633","https://openalex.org/W163486784","https://openalex.org/W2048692939","https://openalex.org/W1985315902"],"abstract_inverted_index":{"Adrenaline":[0,38,82],"was":[1,20],"infused":[2],"intravenously":[3],"in":[4,105],"nine":[5],"normal":[6],"volunteers":[7],"to":[8,12,89,95,122,130,134,142,150,160],"plasma":[9],"concentrations":[10],"similar":[11],"those":[13],"found":[14,104],"after":[15,25,68,125,137,145],"myocardial":[16],"infarction.":[17],"This":[18],"study":[19],"undertaken":[21],"on":[22],"three":[23],"occasions":[24],"5":[26],"days'":[27],"treatment":[28],"with":[29,112],"placebo":[30],"or":[31,36,114],"the":[32,40,47,55,70,84,106,153],"beta-adrenoceptor":[33],"antagonists,":[34],"atenolol":[35,113,138],"timolol.":[37,115,146],"increased":[39,54,141],"systolic":[41],"pressure":[42,49,72],"by":[43,50,58,65],"11":[44],"mmHg,":[45,52],"decreased":[46],"diastolic":[48,71],"14":[51],"and":[53,76,139],"heart":[56,77],"rate":[57,78],"7":[59],"beats/min.":[60],"These":[61],"changes":[62,102],"were":[63,103,110],"prevented":[64],"atenolol.":[66],"However,":[67],"timolol":[69],"rose":[73],"(+19":[74],"mmHg)":[75],"fell":[79,119,129],"(-8":[80],"beats/min).":[81],"caused":[83],"corrected":[85],"QT":[86],"interval":[87],"(QTc)":[88],"lengthen":[90],"(0.36":[91],"+/-":[92,97],"0.02":[93],"s":[94],"0.41":[96],"0.06":[98],"s).":[99],"No":[100],"significant":[101],"QTc":[107],"when":[108],"subjects":[109],"pretreated":[111],"The":[116],"serum":[117],"potassium":[118,128,164],"from":[120,152],"4.06":[121],"3.22":[123],"mmol/l":[124,136,144],"adrenaline.":[126],"Serum":[127],"a":[131,156],"lesser":[132],"extent":[133],"3.67":[135],"actually":[140],"4.25":[143],"Adrenaline-mediated":[147],"hypokalaemia":[148],"appears":[149],"result":[151],"stimulation":[154],"of":[155],"beta":[157],"2-adrenoceptor":[158],"linked":[159],"membrane":[161],"Na+/K+-ATPase":[162],"causing":[163],"influx.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
