{"id":"https://openalex.org/W2308969293","doi":"https://doi.org/10.1176/ajp.146.11.1427","title":"Apparent phase advance in diurnal MHPG rhythm in depression","display_name":"Apparent phase advance in diurnal MHPG rhythm in depression","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W2308969293","doi":"https://doi.org/10.1176/ajp.146.11.1427","mag":"2308969293","pmid":"https://pubmed.ncbi.nlm.nih.gov/2817113"},"language":"en","primary_location":{"id":"doi:10.1176/ajp.146.11.1427","doi":"https://doi.org/10.1176/ajp.146.11.1427","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.146.11.1427","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111583712","display_name":"Harry E. Gwirtsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H E Gwirtsman","raw_affiliation_strings":["Brentwood VA Hospital, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brentwood VA Hospital, Los Angeles","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015828524","display_name":"Angelos E Halaris","orcid":"https://orcid.org/0000-0002-6709-3067","observed_orcids":["https://orcid.org/0000-0002-6709-3067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Halaris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112059740","display_name":"A W Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Wolf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108206382","display_name":"Edward M. DeMet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E DeMet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075801402","display_name":"John E. Piletz","orcid":"https://orcid.org/0000-0002-0053-1587","observed_orcids":["https://orcid.org/0000-0002-0053-1587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Piletz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069177557","display_name":"Matthew Marler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Marler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2516,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.47405453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"146","issue":"11","first_page":"1427","last_page":"1433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.621999979019165},{"id":"https://openalex.org/keywords/mhpg","display_name":"MHPG","score":0.8059999942779541},{"id":"https://openalex.org/keywords/diurnal-cycle","display_name":"diurnal cycle","score":0.8270000219345093},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8899999856948853},{"id":"https://openalex.org/keywords/phase-advance","display_name":"phase advance","score":0.6899999976158142},{"id":"https://openalex.org/keywords/noradrenergic-system","display_name":"noradrenergic system","score":0.7639999985694885},{"id":"https://openalex.org/keywords/melancholic-depression","display_name":"endogenous depression","score":0.8569999933242798},{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acrophase","display_name":"acrophase","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C113324615","wikidata":"https://www.wikidata.org/wiki/Q472302","display_name":"Login","level":2,"score":0.7871561646461487},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.5616670846939087},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5410633683204651},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4962058663368225},{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.4944114685058594},{"id":"https://openalex.org/C2776403943","wikidata":"https://www.wikidata.org/wiki/Q1123260","display_name":"Palpitations","level":2,"score":0.47329750657081604},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44944268465042114},{"id":"https://openalex.org/C139676723","wikidata":"https://www.wikidata.org/wiki/Q1193832","display_name":"Sign (mathematics)","level":2,"score":0.4390886425971985},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.42463916540145874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.404477596282959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29995641112327576},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15517356991767883},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.11012205481529236},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.09049853682518005},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006018","descriptor_name":"Glycols","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1176/ajp.146.11.1427","doi":"https://doi.org/10.1176/ajp.146.11.1427","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.146.11.1427","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:2817113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2817113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4828668073","display_name":null,"funder_award_id":"MH-37664","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7162235947","display_name":null,"funder_award_id":"MH33109","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W41505552","https://openalex.org/W193300339","https://openalex.org/W1794165588","https://openalex.org/W1970284332","https://openalex.org/W1976632402","https://openalex.org/W1981774309","https://openalex.org/W1997683393","https://openalex.org/W2000943191","https://openalex.org/W2001275370","https://openalex.org/W2003267121","https://openalex.org/W2003623977","https://openalex.org/W2006770638","https://openalex.org/W2009940617","https://openalex.org/W2011104380","https://openalex.org/W2011270065","https://openalex.org/W2018420157","https://openalex.org/W2018519409","https://openalex.org/W2021241599","https://openalex.org/W2024276372","https://openalex.org/W2035190763","https://openalex.org/W2041168492","https://openalex.org/W2043136017","https://openalex.org/W2045510940","https://openalex.org/W2046616522","https://openalex.org/W2049165791","https://openalex.org/W2050101039","https://openalex.org/W2051437441","https://openalex.org/W2052024880","https://openalex.org/W2053597117","https://openalex.org/W2054146351","https://openalex.org/W2060086785","https://openalex.org/W2061378977","https://openalex.org/W2067107685","https://openalex.org/W2069076274","https://openalex.org/W2071975563","https://openalex.org/W2072219714","https://openalex.org/W2075044057","https://openalex.org/W2076035026","https://openalex.org/W2077341567","https://openalex.org/W2091560640","https://openalex.org/W2096352061","https://openalex.org/W2114645575","https://openalex.org/W2148021618","https://openalex.org/W2159020344","https://openalex.org/W2171682961","https://openalex.org/W2295580451","https://openalex.org/W2309980614","https://openalex.org/W2332317445","https://openalex.org/W2399297020","https://openalex.org/W2407092981","https://openalex.org/W2410101169","https://openalex.org/W2411454954","https://openalex.org/W2416086055","https://openalex.org/W2418329321","https://openalex.org/W2424959181","https://openalex.org/W2432083997","https://openalex.org/W2441951593","https://openalex.org/W2463004917","https://openalex.org/W2473396247"],"related_works":["https://openalex.org/W2088345891","https://openalex.org/W2473396247","https://openalex.org/W1967191643","https://openalex.org/W2054146351","https://openalex.org/W2051437441","https://openalex.org/W2109100135","https://openalex.org/W1965036952","https://openalex.org/W2410091259","https://openalex.org/W2073749725","https://openalex.org/W2052024880"],"abstract_inverted_index":{"Several":[0],"investigators":[1],"have":[2],"proposed":[3],"that":[4,8],"diurnal":[5,24,41],"rhythms,":[6],"particularly":[7],"of":[9,30,43,103],"the":[10,28],"norepinephrine":[11],"metabolite":[12],"3-methoxy-4-hydroxyphenylglycol":[13],"(MHPG),":[14],"show":[15],"abnormalities":[16],"in":[17,27,53,60,107,111],"affective":[18],"disorders.":[19],"The":[20],"present":[21],"study":[22,97],"compared":[23],"MHPG":[25,44],"rhythms":[26,110],"plasma":[29],"18":[31],"male":[32,38],"depressed":[33,61,112],"patients":[34],"and":[35,84,99],"12":[36],"healthy":[37],"volunteers.":[39],"A":[40],"rhythm":[42],"closely":[45],"fit":[46],"to":[47,56],"a":[48,57,91],"cosine":[49],"model":[50],"was":[51,88],"observed":[52],"volunteers":[54],"and,":[55],"lesser":[58],"extent,":[59],"patients.":[62,113],"Patients,":[63],"especially":[64],"those":[65],"with":[66,86,90],"endogenous":[67],"depression":[68],"(N":[69],"=":[70,79],"11),":[71],"demonstrated":[72],"an":[73],"earlier":[74],"acrophase":[75],"(mean":[76],"+/-":[77,81],"SD":[78],"12.53":[80],"3.38":[82],"hours),":[83],"treatment":[85],"desipramine":[87],"associated":[89],"significant":[92],"(3-hour)":[93],"phase":[94,105],"delay.":[95],"This":[96],"confirms":[98],"extends":[100],"previous":[101],"reports":[102],"apparent":[104],"advances":[106],"circadian":[108],"noradrenergic":[109]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}