{"id":"https://openalex.org/W2308896852","doi":null,"title":"Cancers as systemic functional diseases, Part 2: clinical implications.","display_name":"Cancers as systemic functional diseases, Part 2: clinical implications.","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2308896852","mag":"2308896852","pmid":"https://pubmed.ncbi.nlm.nih.gov/20486625"},"language":"en","primary_location":{"id":"pmid:20486625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20486625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109155536","display_name":"Jeffrey Keith Spaneas Bland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey Bland","raw_affiliation_strings":["Institute for Functional Medicine, Gig Harbor, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Functional Medicine, Gig Harbor, Washington, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109155536"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"16","issue":"3","first_page":"54","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.16369999945163727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.16369999945163727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.13650000095367432,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.12060000002384186,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chronic-disease-management","display_name":"chronic disease management","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cancer-survivorship","display_name":"cancer survivorship","score":0.6990000009536743},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.5009999871253967},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.6819999814033508},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.671999990940094},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.7730000019073486},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.596444845199585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5579405426979065},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5015678405761719},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.48675537109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4434768557548523},{"id":"https://openalex.org/C2776463041","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer screening","level":3,"score":0.4252215325832367},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40893515944480896},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3789743185043335}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006266","descriptor_name":"Health Education","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010347","descriptor_name":"Patient Care Planning","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D010353","descriptor_name":"Patient Education as Topic","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D012648","descriptor_name":"Self Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:20486625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20486625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1587501597","https://openalex.org/W1874942157","https://openalex.org/W1969536729","https://openalex.org/W1970263201","https://openalex.org/W1982279452","https://openalex.org/W1984361737","https://openalex.org/W1988092401","https://openalex.org/W1993937831","https://openalex.org/W2015705446","https://openalex.org/W2024008007","https://openalex.org/W2030511481","https://openalex.org/W2031138054","https://openalex.org/W2038812418","https://openalex.org/W2041559106","https://openalex.org/W2063351659","https://openalex.org/W2066089129","https://openalex.org/W2066110731","https://openalex.org/W2071947632","https://openalex.org/W2079894826","https://openalex.org/W2080257278","https://openalex.org/W2082439166","https://openalex.org/W2109284306","https://openalex.org/W2110600130","https://openalex.org/W2114487412","https://openalex.org/W2128113547","https://openalex.org/W2132628605","https://openalex.org/W2136143580","https://openalex.org/W2140940088","https://openalex.org/W2147150575","https://openalex.org/W2150791953","https://openalex.org/W2155878103","https://openalex.org/W2158417496","https://openalex.org/W2165428460","https://openalex.org/W2167402114","https://openalex.org/W2225848857","https://openalex.org/W2335679869","https://openalex.org/W2798979732","https://openalex.org/W2842063781"],"related_works":["https://openalex.org/W7208012080","https://openalex.org/W3040855297","https://openalex.org/W2883777660","https://openalex.org/W4391233105","https://openalex.org/W2564166704","https://openalex.org/W4386376087","https://openalex.org/W4386375953","https://openalex.org/W2181359645","https://openalex.org/W1979744503","https://openalex.org/W2261070115"],"abstract_inverted_index":{"T":[0],"he":[1],"emerging":[2,251],"view":[3],"is":[4,35,45,94,129,165,250,264,358],"that":[5,16,34,55,147,263,344,357],"many":[6,22],"cancers,":[7],"due":[8],"to":[9,18,59,191,246,266,271],"present":[10],"therapeutics,":[11],"may":[12],"become":[13],"chronic":[14,284],"diseases":[15],"need":[17],"be":[19],"managed":[20],"over":[21],"years":[23],"with":[24,176,218,339,360],"diet,":[25],"lifestyle,":[26],"and":[27,87,109,145,158,209,221,317,330,351],"environment":[28],"changes.'-^":[29],"Management":[30],"of":[31,40,50,68,92,97,118,126,132,163,168,182,195,201,216,234,240,278,286,292,306,319,324,335,348,355,364],"the":[32,38,48,61,79,95,105,130,166,193,199,214,232,255,276,283,287,299,304,315,353],"patient":[33],"appropriate":[36],"for":[37,174,254,282,313],"stage":[39],"his":[41,268],"or":[42,52,115,134,188],"her":[43],"disease":[44,196],"dependent":[46],"upon":[47],"availability":[49],"biomarkers":[51,343],"screening":[53,69,76,93,127,183,224,294,310],"tests":[54,70,225],"have":[56,71,227,332],"been":[57,72,228],"validated":[58],"define":[60],"status":[62],"ofthe":[63,257,260],"individual.":[64],"Traditionally,":[65],"four":[66],"types":[67],"employed,":[73],"including":[74,138],"early-detection":[75],"such":[77,102,197,204],"as":[78,103,170,198,205,273,275],"Pap":[80],"test,":[81],"mammography,":[82],"dermatology":[83],"screen,":[84,86],"oral":[85],"colonoscopy.":[88],"The":[89,123,179,322],"second":[90],"type":[91,125,181,291],"use":[96,131,167,200],"gene-based":[98],"cellular":[99],"tumor-specific":[100],"markers":[101,137],"KRAS,":[104],"APC":[106],"gene,":[107],"TP53":[108],"BAT26":[110],"in":[111,120,213,230,236,311],"stool":[112],"sample":[113],"DNA,":[114],"cytological":[116],"examination":[117],"cells":[119],"sputum":[121],"samples.":[122],"third":[124],"test":[128,184],"serum":[133,187],"urine":[135,189,215],"genetic":[136],"cyclin":[139],"E,":[140],"MCM,":[141],"PCNA,":[142],"pl6,":[143],"BCL-2,":[144],"VEGF":[146],"monitor":[148],"cell-cycle":[149,155],"progression,":[150],"DNA":[151,153],"replication,":[152],"synthesis,":[154],"control,":[156],"antiapoptosis,":[157],"angiogenesis.":[159],"One":[160],"prime":[161],"example":[162],"this":[164],"CA-125":[169],"a":[171,237,279],"tumor":[172],"marker":[173],"women":[175],"ovarian":[177],"cancer.":[178,241,361],"fourth":[180],"employs":[185],"soluble":[186],"metabolites":[190,203],"follow":[192],"course":[194,233],"catecholamine":[202],"vanillylmandelic":[206],"acid":[207,211],"(VMA)":[208],"homovanillic":[210],"(HVA)":[212],"patients":[217],"neuroblastoma.":[219],"Genetic":[220],"molecular":[222],"biological":[223],"traditionally":[226],"used":[229],"following":[231],"therapy":[235],"well-described":[238],"form":[239],"Beyond":[242],"these":[243,346],"traditional":[244],"approaches":[245],"cancer":[247,272,288,325],"assessment,":[248],"however,":[249],"another":[252],"strategy":[253],"assessment":[256],"fimctional":[258],"state":[259,354],"patient's":[261],"physiology":[262,350,366],"related":[265],"both":[267],"individual":[269],"predisposition":[270],"well":[274],"design":[277],"personalized":[280],"program":[281],"management":[285],"survivor.":[289],"This":[290],"biomarker":[293],"takes":[295],"its":[296],"lead":[297],"fi-om":[298,326],"pioneering":[300],"work":[301],"done":[302],"on":[303],"value":[305],"prostate-specific":[307],"antigen":[308],"(PSA)":[309],"males":[312],"defining":[314],"risk":[316],"progression":[318,331],"prostate":[320],"cancer,'":[321],"states":[323],"initiation":[327],"through":[328],"promotion":[329],"different":[333],"stages":[334,347,363],"disturbed":[336,365],"metabolism":[337],"associated":[338],"them.":[340],"There":[341],"are":[342],"identify":[345],"distorted":[349],"reflect":[352],"fiinction":[356],"consistent":[359],"These":[362],"include":[367]},"counts_by_year":[{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
