{"id":"https://openalex.org/W23084847","doi":null,"title":"A blind parallel comparative study of the efficacy and safety of rovamycin versus augmentin in the treatment of acute otitis media.","display_name":"A blind parallel comparative study of the efficacy and safety of rovamycin versus augmentin in the treatment of acute otitis media.","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W23084847","mag":"23084847","pmid":"https://pubmed.ncbi.nlm.nih.gov/12403032"},"language":"en","primary_location":{"id":"pmid:12403032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12403032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West African journal of medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113724942","display_name":"N Mgbor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164256","display_name":"University of Nigeria Teaching Hospital","ror":"https://ror.org/05fx5mz56","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210164256"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"N C Mgbor","raw_affiliation_strings":["Department of Otolaryngology, University of Nigeria Teaching Hospital, Enugu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Nigeria Teaching Hospital, Enugu","institution_ids":["https://openalex.org/I4210164256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110326862","display_name":"R E Umeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Umeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00334001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"2","first_page":"117","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.9300000071525574},{"id":"https://openalex.org/keywords/acute-otitis-media","display_name":"acute otitis media","score":0.8870000243186951},{"id":"https://openalex.org/keywords/antibiotic-efficacy","display_name":"antibiotic efficacy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fever-clearance","display_name":"fever clearance","score":0.8230000138282776},{"id":"https://openalex.org/keywords/otalgia","display_name":"otalgia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5370000004768372},{"id":"https://openalex.org/keywords/bacterial-otitis-media","display_name":"bacterial otitis media","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9671740531921387},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8541933298110962},{"id":"https://openalex.org/C2908979688","wikidata":"https://www.wikidata.org/wiki/Q223254","display_name":"Acute otitis media","level":3,"score":0.6901821494102478},{"id":"https://openalex.org/C3018954396","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Single blind","level":3,"score":0.5970043540000916},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5124464631080627},{"id":"https://openalex.org/C2994123057","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Cure rate","level":2,"score":0.49802303314208984},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.4687740206718445},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.4461654722690582},{"id":"https://openalex.org/C2776439223","wikidata":"https://www.wikidata.org/wiki/Q480700","display_name":"Otitis","level":2,"score":0.3558654189109802},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3490539491176605},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34139400720596313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33127862215042114},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2842448949813843},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24914759397506714}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010033","descriptor_name":"Otitis Media","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010033","descriptor_name":"Otitis Media","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015572","descriptor_name":"Spiramycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019980","descriptor_name":"Amoxicillin-Potassium Clavulanate Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12403032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12403032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"West African journal of medicine","raw_type":"Clinical Trial"},{"id":"mag:23084847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12403032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2120035496","https://openalex.org/W2008280994","https://openalex.org/W2056095352","https://openalex.org/W2065420324","https://openalex.org/W1985076750","https://openalex.org/W2116971894","https://openalex.org/W2101918654","https://openalex.org/W1970450931","https://openalex.org/W2098749611","https://openalex.org/W2139578785","https://openalex.org/W2225709853","https://openalex.org/W2059677301","https://openalex.org/W2105794268","https://openalex.org/W2118623662","https://openalex.org/W1661467263","https://openalex.org/W4245371159","https://openalex.org/W2110056660","https://openalex.org/W2110962836"],"related_works":["https://openalex.org/W1840929356","https://openalex.org/W2071120458","https://openalex.org/W323229595","https://openalex.org/W7097234168","https://openalex.org/W2093657336","https://openalex.org/W2065697368","https://openalex.org/W2140052909","https://openalex.org/W2027166036","https://openalex.org/W2007260345","https://openalex.org/W2079157419"],"abstract_inverted_index":{"A":[0],"single":[1],"blind":[2],"randontised":[3],"controlled":[4],"parallel":[5],"clinical":[6],"trial":[7,100],"of":[8,62,73,96,98],"Rovamycin":[9,35,92,123,139],"was":[10,17,106],"conducted":[11],"in":[12,21,70,77,81,102,113,131,165],"which":[13],"(Rovamycin":[14],"Rhone-Poulenc":[15],"Rorer)":[16],"compared":[18],"with":[19,23,33],"Augmentin":[20,37,87,144],"patients":[22,28,76,84],"acute":[24],"otitis":[25,136],"media.":[26,137],"Forty":[27],"were":[29,41,51],"randomised":[30],"to":[31,128],"treatment":[32,63],"either":[34],"or":[36],"and":[38,45,56,88,116,162],"the":[39,74,86,99,132,146],"drugs":[40,101],"evaluated":[42],"for":[43,85,91,145,171],"efficacy":[44,48],"safety.":[46],"The":[47],"parameters":[49],"used":[50],"fever":[52,68],"clearance,":[53],"symptom":[54],"clearance":[55],"cure":[57],"rate":[58],"after":[59,93],"8":[60,94],"days":[61,95],"Our":[64],"study":[65],"showed":[66,121],"that":[67,122,148],"regressed":[69],"19":[71,82],"(95%)":[72],"20":[75],"both":[78],"groups;":[79],"otalgia":[80],"(95)":[83],"18":[89],"(90%)":[90],"application":[97],"these":[103],"parameters.":[104],"There":[105],"also":[107],"no":[108],"significant":[109],"difference":[110],"between":[111],"them":[112],"their":[114],"safety":[115],"tolerability":[117],"profiles.":[118],"These":[119],"results":[120],"is":[124,149],"a":[125,153],"useful":[126],"addition":[127],"our":[129],"armamentarium":[130],"fight":[133],"against":[134,156],"bacterial":[135],"Operationally,":[138],"has":[140],"an":[141],"advantage":[142],"over":[143],"reason":[147],"given":[150],"only":[151],"twice":[152],"day":[154],"as":[155],"thrice-daily":[157],"dosage":[158],"f":[159],"orAugmentin.":[160],"Compliance":[161],"consequently":[163],"effectiveness":[164],"practices":[166],"should":[167],"therefore":[168],"be":[169],"better":[170],"Rovamycin.":[172]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}