{"id":"https://openalex.org/W2308408339","doi":"https://doi.org/10.4049/jimmunol.182.supp.135.41","title":"Surfactant protein-A interacts with TLR4 and affects the phagocytic function of dendritic cells (135.41)","display_name":"Surfactant protein-A interacts with TLR4 and affects the phagocytic function of dendritic cells (135.41)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2308408339","doi":"https://doi.org/10.4049/jimmunol.182.supp.135.41","mag":"2308408339"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.135.41","doi":"https://doi.org/10.4049/jimmunol.182.supp.135.41","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.135.41","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091711589","display_name":"Shanjana Awasthi","orcid":"https://orcid.org/0000-0003-1249-0708","observed_orcids":["https://orcid.org/0000-0003-1249-0708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanjana Awasthi","raw_affiliation_strings":["Pharmaceutical Sciences","1Pharmaceutical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"1Pharmaceutical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109710826","display_name":"Roman F. Wolf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Wolf","raw_affiliation_strings":["Comparative Medicine","2Comparative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine","institution_ids":[]},{"raw_affiliation_string":"2Comparative Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090627199","display_name":"Gary L. White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary White","raw_affiliation_strings":["Comparative Medicine","2Comparative Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comparative Medicine","institution_ids":[]},{"raw_affiliation_string":"2Comparative Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006430684","display_name":"Vibhudutta Awasthi","orcid":"https://orcid.org/0000-0002-3611-9009","observed_orcids":["https://orcid.org/0000-0002-3611-9009"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibhudutta Awasthi","raw_affiliation_strings":["Pharmaceutical Sciences, University of Oklahoma Health Science Center , Oklahoma City, Ok","3Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, Ok"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences, University of Oklahoma Health Science Center , Oklahoma City, Ok","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"3Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, Ok","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"Supplement_1","first_page":"135.41","last_page":"135.41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surfactant-protein-a","display_name":"surfactant protein A","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9229999780654907},{"id":"https://openalex.org/keywords/md-2","display_name":"MD-2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8629999756813049},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lung-innate-immunity","display_name":"lung innate immunity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pathogen-recognition","display_name":"pathogen recognition","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7688621878623962},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.7482007145881653},{"id":"https://openalex.org/C161478664","wikidata":"https://www.wikidata.org/wiki/Q901955","display_name":"Phagosome","level":3,"score":0.7012960910797119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5660070180892944},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4879969656467438},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4759212136268616},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4421398937702179},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4414825439453125},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3709125518798828},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3379715085029602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19662484526634216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16809475421905518}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.135.41","doi":"https://doi.org/10.4049/jimmunol.182.supp.135.41","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.135.41","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137825653","https://openalex.org/W2030426394","https://openalex.org/W2270752404","https://openalex.org/W2189003912","https://openalex.org/W1545754268","https://openalex.org/W2123694117","https://openalex.org/W2049985120","https://openalex.org/W2163394126","https://openalex.org/W2130177206","https://openalex.org/W2077448373"],"abstract_inverted_index":{"Abstract":[0],"The":[1,94,166],"surfactant":[2],"protein":[3,161],"(SP)-A":[4],"and":[5,14,21,31,43,52,68,74,89,139,171,192,225],"Toll-like":[6],"receptor":[7],"(TLR4)":[8],"proteins":[9,73,78,99,138,173,194],"are":[10],"known":[11],"as":[12],"secretory":[13],"cellular":[15],"pathogen":[16],"pattern":[17],"recognition":[18,28],"receptors,":[19],"respectively,":[20],"play":[22],"an":[23],"important":[24],"role":[25],"in":[26,54,102,113,130],"the":[27,36,61,83,97,111,117,120,148,159,179,190,198,221,228],"of":[29,76,82,116,132,169,181,201],"pathogens":[30],"host":[32],"defense.":[33],"In":[34,56],"lung,":[35],"TLR4":[37,70,226],"is":[38,45],"expressed":[39],"by":[40,47,104,185,231],"immune":[41],"cells,":[42,119],"SP-A":[44,67,134,160,170,191,213,224],"synthesized":[46],"type":[48],"II":[49],"epithelial":[50],"cells":[51,86,121,203],"secreted":[53],"alveoli.":[55],"this":[57],"study,":[58],"we":[59],"investigated":[60],"interaction":[62,95,222],"between":[63,96,223],"purified":[64],"baboon":[65,91],"lung":[66],"recombinant":[69,136],"(extracellular":[71],"domain)-MD2":[72],"effects":[75],"these":[77],"on":[79,153],"phagocytic":[80,114,199],"function":[81],"human":[84],"myelomonocytic":[85],"(KG1)":[87],"derived-":[88],"primary":[90],"lung-dendritic":[92],"cells.":[93,187,233],"two":[98],"was":[100,151,174],"studied":[101],"vitro":[103],"a":[105,154],"microwell":[106],"based":[107],"method.":[108],"For":[109],"measuring":[110],"changes":[112],"ability":[115,200],"dendritic":[118,186,202,232],"were":[122,195],"incubated":[123],"with":[124,212],"pHrodo-labeled,":[125],"heat-killed":[126],"Escherichia":[127],"coli":[128,145,183],"bioparticles":[129,146,184],"presence":[131],"native":[133],"and/or":[135],"TLR4-MD":[137],"fluorescence":[140],"released":[141],"from":[142,209],"ingested":[143],"E.":[144,182],"inside":[147],"acidic":[149],"phagosome":[150],"read":[152],"fluorometer.":[155],"We":[156],"found":[157,175],"that":[158,220],"binds":[162],"to":[163,176],"TLR4-MD2":[164,172,193,215],"protein.":[165],"exogenous":[167],"addition":[168],"significantly":[177],"increase":[178],"phagocytosis":[180,230],"However,":[188],"when":[189],"added":[196],"together,":[197],"either":[204],"remained":[205],"unaltered":[206],"or":[207,214],"decreased":[208],"those":[210],"treated":[211],"alone.":[216],"These":[217],"results":[218],"suggest":[219],"affects":[227],"bacterial":[229]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}