{"id":"https://openalex.org/W2308309461","doi":"https://doi.org/10.1007/978-1-4899-1540-5_95","title":"The Push-Pull Mechanism of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants","display_name":"The Push-Pull Mechanism of Dealkylation in Soman-Inhibited Cholinesterases and Their Mutants","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2308309461","doi":"https://doi.org/10.1007/978-1-4899-1540-5_95","mag":"2308309461"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4899-1540-5_95","doi":"https://doi.org/10.1007/978-1-4899-1540-5_95","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4899-1540-5_95","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure and Function of Cholinesterases and Related Proteins","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W578736495","display_name":"Structure and Function of Cholinesterases and Related Proteins"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053162331","display_name":"Ildiko M. Kovach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84470341","display_name":"Catholic University of America","ror":"https://ror.org/047yk3s18","country_code":"US","type":"education","lineage":["https://openalex.org/I84470341"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ildiko M. Kovach","raw_affiliation_strings":["Department of Chemistry, The Catholic University of America, Washington, DC, 20064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Catholic University of America, Washington, DC, 20064, USA","institution_ids":["https://openalex.org/I84470341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053162331"],"corresponding_institution_ids":["https://openalex.org/I84470341"],"apc_list":null,"apc_paid":null,"fwci":0.9444,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.78466077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"339","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soman","display_name":"soman","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cholinesterase-inhibition","display_name":"cholinesterase inhibition","score":0.8050000071525574},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dealkylation","display_name":"dealkylation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/irreversible-inhibition","display_name":"irreversible inhibition","score":0.6299999952316284},{"id":"https://openalex.org/keywords/organophosphorus-nerve-agents","display_name":"organophosphorus nerve agents","score":0.722000002861023},{"id":"https://openalex.org/keywords/catalytic-triad","display_name":"catalytic triad","score":0.8679999709129333},{"id":"https://openalex.org/keywords/histidine-protonation","display_name":"histidine protonation","score":0.640999972820282},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/enzyme-mutants","display_name":"enzyme mutants","score":0.6110000014305115},{"id":"https://openalex.org/keywords/torpedo-californica-acetylcholinesterase","display_name":"Torpedo californica acetylcholinesterase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/acylation-mechanism","display_name":"acylation mechanism","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C145770059","wikidata":"https://www.wikidata.org/wiki/Q751908","display_name":"Catalytic triad","level":4,"score":0.8878442049026489},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.79758620262146},{"id":"https://openalex.org/C193557335","wikidata":"https://www.wikidata.org/wiki/Q61424","display_name":"Acylation","level":3,"score":0.7512869834899902},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.7070737481117249},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.6865679025650024},{"id":"https://openalex.org/C2780266723","wikidata":"https://www.wikidata.org/wiki/Q408044","display_name":"Soman","level":4,"score":0.6695416569709778},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.603137731552124},{"id":"https://openalex.org/C123419017","wikidata":"https://www.wikidata.org/wiki/Q7826734","display_name":"Torpedo","level":4,"score":0.5926154851913452},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5318291783332825},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.5101483464241028},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.48855456709861755},{"id":"https://openalex.org/C160964918","wikidata":"https://www.wikidata.org/wiki/Q320141","display_name":"Leaving group","level":3,"score":0.4537236988544464},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4504934847354889},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.44607993960380554},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.44046998023986816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23911261558532715},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1971917450428009},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.08695244789123535},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4899-1540-5_95","doi":"https://doi.org/10.1007/978-1-4899-1540-5_95","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4899-1540-5_95","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure and Function of Cholinesterases and Related Proteins","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1778515962","https://openalex.org/W1965549661","https://openalex.org/W1966964730","https://openalex.org/W1968662992","https://openalex.org/W1995948694","https://openalex.org/W1998312296","https://openalex.org/W2080554347","https://openalex.org/W2085958374","https://openalex.org/W2086758152","https://openalex.org/W2087762757","https://openalex.org/W2088636647","https://openalex.org/W2093377852","https://openalex.org/W2109507519","https://openalex.org/W2270309244","https://openalex.org/W2395525578"],"related_works":["https://openalex.org/W1965549661","https://openalex.org/W2062448952","https://openalex.org/W2005874283","https://openalex.org/W2088395036","https://openalex.org/W2017993238","https://openalex.org/W2044795328","https://openalex.org/W2005833473","https://openalex.org/W2338477851","https://openalex.org/W2053972543","https://openalex.org/W2327681615"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}