{"id":"https://openalex.org/W2308304031","doi":null,"title":"Estudo comparativo da imunomarca\u00e7\u00e3o da p53 em carcinomas epiderm\u00f3ides bucais de s\u00edtios anat\u00f4micos diferentes","display_name":"Estudo comparativo da imunomarca\u00e7\u00e3o da p53 em carcinomas epiderm\u00f3ides bucais de s\u00edtios anat\u00f4micos diferentes","publication_year":2004,"publication_date":"2004-02-16","ids":{"openalex":"https://openalex.org/W2308304031","mag":"2308304031"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:2130774","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7LWGWD","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1843/ZMRO-7LWGWD","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009463431","display_name":"Claudia Teixeira Sa Cabral","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claudia Teixeira Sa Cabral","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009463431"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-immunostaining","display_name":"p53 immunostaining","score":0.753000020980835},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tp53-gene","display_name":"TP53 gene","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tongue-cancer","display_name":"tongue cancer","score":0.5830000042915344},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.4869999885559082},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.5260000228881836},{"id":"https://openalex.org/keywords/oral-carcinogenesis","display_name":"oral carcinogenesis","score":0.6050000190734863},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5360000133514404},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/clinicopathological-variables","display_name":"clinicopathological variables","score":0.5289999842643738},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4363250732421875},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4290342926979065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35338374972343445},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32350635528564453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16790130734443665}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:2130774","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7LWGWD","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.ufmg.br:1843/ZMRO-7LWGWD","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7LWGWD","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2308304031","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ufmg.br/bitstream/1843/ZMRO-7LWGWD/1/disserta__o_mestrado_cl_udia_s_.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:2130774","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1843/ZMRO-7LWGWD","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFMG","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W86487678","https://openalex.org/W1537022787","https://openalex.org/W1559764396","https://openalex.org/W1597704210","https://openalex.org/W1660800498","https://openalex.org/W1813102148","https://openalex.org/W1965062994","https://openalex.org/W1971247023","https://openalex.org/W1971571204","https://openalex.org/W1972641033","https://openalex.org/W1975689927","https://openalex.org/W1976282718","https://openalex.org/W1977310229","https://openalex.org/W1978633302","https://openalex.org/W1979121243","https://openalex.org/W1979771543","https://openalex.org/W1984140021","https://openalex.org/W1985421003","https://openalex.org/W1990858972","https://openalex.org/W1991765557","https://openalex.org/W2004201173","https://openalex.org/W2005701686","https://openalex.org/W2006374996","https://openalex.org/W2006757889","https://openalex.org/W2007618242","https://openalex.org/W2010444010","https://openalex.org/W2011049995","https://openalex.org/W2016455125","https://openalex.org/W2017627639","https://openalex.org/W2019525569","https://openalex.org/W2021709131","https://openalex.org/W2022767357","https://openalex.org/W2029370619","https://openalex.org/W2038236486","https://openalex.org/W2038336555","https://openalex.org/W2042006572","https://openalex.org/W2042316019","https://openalex.org/W2047416792","https://openalex.org/W2047506292","https://openalex.org/W2047596219","https://openalex.org/W2047966848","https://openalex.org/W2048091379","https://openalex.org/W2050555482","https://openalex.org/W2055993544","https://openalex.org/W2060108442","https://openalex.org/W2061201301","https://openalex.org/W2061256710","https://openalex.org/W2063977216","https://openalex.org/W2064330613","https://openalex.org/W2067311693","https://openalex.org/W2070999190","https://openalex.org/W2071702975","https://openalex.org/W2077101738","https://openalex.org/W2078664608","https://openalex.org/W2079530750","https://openalex.org/W2079831888","https://openalex.org/W2082539367","https://openalex.org/W2083627679","https://openalex.org/W2085673686","https://openalex.org/W2086633541","https://openalex.org/W2090025028","https://openalex.org/W2092585633","https://openalex.org/W2095138814","https://openalex.org/W2095353012","https://openalex.org/W2098849527","https://openalex.org/W2099227670","https://openalex.org/W2104174746","https://openalex.org/W2104382186","https://openalex.org/W2104451798","https://openalex.org/W2106787323","https://openalex.org/W2111467500","https://openalex.org/W2113078044","https://openalex.org/W2113317708","https://openalex.org/W2119102742","https://openalex.org/W2120565720","https://openalex.org/W2121030616","https://openalex.org/W2130723337","https://openalex.org/W2130823863","https://openalex.org/W2133521007","https://openalex.org/W2134552606","https://openalex.org/W2137884121","https://openalex.org/W2139180022","https://openalex.org/W2141007405","https://openalex.org/W2142248814","https://openalex.org/W2143408262","https://openalex.org/W2147504123","https://openalex.org/W2149703879","https://openalex.org/W2149853199","https://openalex.org/W2155818823","https://openalex.org/W2156004684","https://openalex.org/W2156176929","https://openalex.org/W2158900915","https://openalex.org/W2160407692","https://openalex.org/W2166633890","https://openalex.org/W2167702196","https://openalex.org/W2171334157","https://openalex.org/W2171854919","https://openalex.org/W2172065093","https://openalex.org/W2312732552","https://openalex.org/W2314336928","https://openalex.org/W2316316905","https://openalex.org/W2316896018","https://openalex.org/W2319897304","https://openalex.org/W2324774713","https://openalex.org/W2325557141","https://openalex.org/W2418149280","https://openalex.org/W2430218495","https://openalex.org/W2436505567","https://openalex.org/W3082763768"],"related_works":["https://openalex.org/W2091454590","https://openalex.org/W2569977734","https://openalex.org/W2339224802","https://openalex.org/W4404384711","https://openalex.org/W4390414597","https://openalex.org/W4389280707","https://openalex.org/W2312371010","https://openalex.org/W2063318864","https://openalex.org/W2518514007","https://openalex.org/W1559764396"],"abstract_inverted_index":{"O":[0,25,120],"papel":[1],"das":[2,224,231,238],"altera\u00e7\u00f5es":[3],"do":[4,95,100,188,289],"gene":[5],"supressor":[6],"de":[7,11,22,39,45,53,61,70,76,82,87,125,137,156,186,190,247,274,281,305,310],"tumor":[8,290,301],"TP53":[9],"e":[10,43,98,105,114,183,210,234,260,302],"seuproduto":[12],"prot\u00e9ico,":[13],"a":[14,29,35,64,112,140,169,218,244,269,286,296],"p53,":[15],"j\u00e1":[16],"est\u00e1":[17],"bem":[18,205,226,256],"estabelecido":[19],"no":[20,300,308],"processo":[21],"carcinog\u00eanese":[23],"bucal.":[24],"carcinoma":[26],"epiderm\u00f3ide":[27],"\u00e9":[28],"malignidade":[30,187],"intrabucal":[31],"mais":[32,41],"comum,":[33],"sendo":[34,90],"l\u00edngua":[36,157,282],"o":[37,44,59,272,303],"s\u00edtio":[38,292],"acometimento":[40],"freq\u00fcente":[42],"pior":[46],"progn\u00f3stico.":[47],"Avaliou-se,":[48],"nesse":[49],"estudo,":[50],"comparativamente,":[51],"atrav\u00e9s":[52],"t\u00e9cnica":[54],"imunoistoqu\u00edmica":[55],"utilizando-se":[56],"oclone":[57],"DO-1,":[58],"padr\u00e3o":[60,273],"imunomarca\u00e7\u00e3o":[62,138,216,275,297],"para":[63,111,139,168,198,217],"p53":[65,113,141,170,219,277,299],"em":[66,221,228,235,264],"43":[67],"amostras":[68],"teciduais":[69],"carcinomas":[71,279],"epiderm\u00f3ides":[72,280],"da":[73,200,254,276,298],"cavidade":[74],"bucal":[75],"s\u00edtios":[77,144,161,252],"anat\u00f4micos":[78,253],"diferentes.":[79],"A":[80,215],"m\u00e9dia":[81],"idade":[83,182,261],"dos":[84,135,262],"pacientes":[85],"foi":[86,124],"58,6":[88],"anos,":[89],"que":[91],"35":[92],"(81,4%)":[93],"eram":[94],"sexo":[96,101,259],"masculino":[97],"8":[99],"feminino":[102],"(18,6%).":[103],"Trinta":[104],"tr\u00eas":[106],"les\u00f5es":[107,116,155,172,196,225],"(76,8%)":[108],"mostraram":[109],"positividade":[110],"10":[115,211],"foram":[117],"p53-negativas":[118],"(23,2%).":[119],"\u00edndice":[121],"m\u00e9dio":[122],"deimunomarca\u00e7\u00e3o":[123],"48,37%.":[126],"N\u00e3o":[127],"houve":[128,150],"diferen\u00e7a":[129,151],"estatisticamente":[130],"significativa":[131],"entre":[132,249,258,295],"as":[133,154],"m\u00e9dias":[134],"\u00edndices":[136],"nos":[142,278],"diferentes":[143],"analisados.":[145],"Da":[146],"mesma":[147],"forma,":[148],"n\u00e3o":[149,173,245,284,314],"quando":[152],"comparadas":[153],"com":[158],"os":[159,250],"outros":[160],"anat\u00f4micos,":[162],"agrupados":[163],"ou":[164],"isoladamente.":[165],"Igualmente,":[166],"aimunomarca\u00e7\u00e3o":[167],"nas":[171],"esteve":[174],"associada":[175],"\u00e0s":[176],"outras":[177],"vari\u00e1veis":[178],"clinicopatol\u00f3gicas":[179],"avaliadas:":[180],"sexo,":[181],"gradua\u00e7\u00e3o":[184],"histol\u00f3gica":[185],"fronte":[189,309],"invas\u00e3o":[191,311],"tumoral":[192,312],"(GHM-FIT).":[193],"Das":[194],"41/43":[195],"dispon\u00edveis":[197],"an\u00e1lise":[199],"GHM-FIT,":[201],"14":[202],"(34,15%)":[203],"mostraram-se":[204],"diferenciadas,":[206,227,233],"17":[207],"(41,46%)":[208],"moderadamente,":[209],"(24,39%)":[212],"pouco":[213,239],"diferenciadas.":[214,240],"foivista":[220],"11/14":[222],"(78,6%)":[223],"15/17":[229],"(88,2%)":[230],"moderadamente":[232],"6/10":[236],"(60%)":[237],"Esses":[241],"resultados":[242],"sugerem":[243],"exist\u00eancia":[246],"diferen\u00e7as":[248],"diversos":[251],"boca,":[255],"como":[257],"pacientes,":[263],"rela\u00e7\u00e3o":[265],"aos":[266],"mecanismosque":[267],"envolvem":[268],"p53.":[270],"Assim,":[271],"parece":[283],"refletir":[285],"maior":[287],"agressividade":[288],"neste":[291],"a\u00e7\u00e3o":[293],"direta":[294],"grau":[304],"diferencia\u00e7\u00e3o":[306],"celular":[307],"tamb\u00e9m":[313],"p\u00f4de":[315],"ser":[316],"estabelecida.":[317]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}
