{"id":"https://openalex.org/W2308109441","doi":null,"title":"Acylation state determines the action of ghrelin on energy and glucose metabolism","display_name":"Acylation state determines the action of ghrelin on energy and glucose metabolism","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2308109441","mag":"2308109441"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1380556886","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071230353","display_name":"Kristy M. Heppner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristy M. Heppner","raw_affiliation_strings":["University of Cincinnati**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati**","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071230353"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17653868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ghrelin-acylation","display_name":"ghrelin acylation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ghrelin-o-acyltransferase","display_name":"ghrelin O-acyltransferase","score":0.9610000252723694},{"id":"https://openalex.org/keywords/growth-hormone-secretagogue-receptor","display_name":"growth hormone secretagogue receptor","score":0.8230000138282776},{"id":"https://openalex.org/keywords/des-acyl-ghrelin","display_name":"des-acyl ghrelin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/acylated-ghrelin","display_name":"acylated ghrelin","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.7519999742507935},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8939999938011169},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.8889999985694885},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.9850000143051147},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9599999785423279},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.4259999990463257},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.5681614875793457},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5454727411270142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49858951568603516},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.48686614632606506},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4286192059516907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.378190815448761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37739837169647217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2869015336036682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22302883863449097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1928914487361908},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14167141914367676},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09269160032272339},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:ucin1380556886","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","raw_type":"text"},{"id":"mag:2308109441","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:ucin1380556886","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380556886","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2308109441.pdf","grobid_xml":"https://content.openalex.org/works/W2308109441.grobid-xml"},"referenced_works_count":170,"referenced_works":["https://openalex.org/W83623201","https://openalex.org/W168198895","https://openalex.org/W253574120","https://openalex.org/W632712882","https://openalex.org/W1537433484","https://openalex.org/W1616806865","https://openalex.org/W1892385952","https://openalex.org/W1964081706","https://openalex.org/W1964489271","https://openalex.org/W1964532167","https://openalex.org/W1964712443","https://openalex.org/W1971743791","https://openalex.org/W1971852856","https://openalex.org/W1973839604","https://openalex.org/W1973955359","https://openalex.org/W1974900519","https://openalex.org/W1975630491","https://openalex.org/W1977461900","https://openalex.org/W1981016212","https://openalex.org/W1982268662","https://openalex.org/W1985071684","https://openalex.org/W1985863005","https://openalex.org/W1987555746","https://openalex.org/W1990095603","https://openalex.org/W1990960682","https://openalex.org/W1991222939","https://openalex.org/W1994554353","https://openalex.org/W1995734405","https://openalex.org/W1996284417","https://openalex.org/W2001161494","https://openalex.org/W2002514583","https://openalex.org/W2004381364","https://openalex.org/W2005058309","https://openalex.org/W2005380415","https://openalex.org/W2005941966","https://openalex.org/W2006713761","https://openalex.org/W2008646871","https://openalex.org/W2008878850","https://openalex.org/W2010605435","https://openalex.org/W2012681547","https://openalex.org/W2013702725","https://openalex.org/W2014213263","https://openalex.org/W2014781237","https://openalex.org/W2015174242","https://openalex.org/W2016173062","https://openalex.org/W2017215225","https://openalex.org/W2018127398","https://openalex.org/W2021247637","https://openalex.org/W2021867559","https://openalex.org/W2027397115","https://openalex.org/W2028212562","https://openalex.org/W2030037892","https://openalex.org/W2032225465","https://openalex.org/W2032297237","https://openalex.org/W2033468788","https://openalex.org/W2033893430","https://openalex.org/W2034145943","https://openalex.org/W2034697008","https://openalex.org/W2036861042","https://openalex.org/W2039033342","https://openalex.org/W2040509326","https://openalex.org/W2041426844","https://openalex.org/W2044976957","https://openalex.org/W2046499742","https://openalex.org/W2047217817","https://openalex.org/W2047589919","https://openalex.org/W2048053645","https://openalex.org/W2048194663","https://openalex.org/W2050854287","https://openalex.org/W2051753034","https://openalex.org/W2056610118","https://openalex.org/W2059488879","https://openalex.org/W2059497272","https://openalex.org/W2059714551","https://openalex.org/W2060936747","https://openalex.org/W2061465125","https://openalex.org/W2063023299","https://openalex.org/W2063052824","https://openalex.org/W2063088317","https://openalex.org/W2064730183","https://openalex.org/W2067472606","https://openalex.org/W2068134092","https://openalex.org/W2068215838","https://openalex.org/W2069302715","https://openalex.org/W2069552504","https://openalex.org/W2072911841","https://openalex.org/W2073360655","https://openalex.org/W2076128586","https://openalex.org/W2076987540","https://openalex.org/W2078171206","https://openalex.org/W2078497741","https://openalex.org/W2081246610","https://openalex.org/W2081666098","https://openalex.org/W2085217050","https://openalex.org/W2085218910","https://openalex.org/W2085258202","https://openalex.org/W2085372550","https://openalex.org/W2086950122","https://openalex.org/W2087357268","https://openalex.org/W2089656605","https://openalex.org/W2090183863","https://openalex.org/W2094486174","https://openalex.org/W2095269214","https://openalex.org/W2095461204","https://openalex.org/W2097743939","https://openalex.org/W2101621799","https://openalex.org/W2102546652","https://openalex.org/W2105363738","https://openalex.org/W2105573142","https://openalex.org/W2106149108","https://openalex.org/W2106488251","https://openalex.org/W2107620313","https://openalex.org/W2107956705","https://openalex.org/W2107960666","https://openalex.org/W2108122320","https://openalex.org/W2108335187","https://openalex.org/W2109993485","https://openalex.org/W2111536564","https://openalex.org/W2111691810","https://openalex.org/W2112202133","https://openalex.org/W2112947586","https://openalex.org/W2113877948","https://openalex.org/W2116775721","https://openalex.org/W2119580431","https://openalex.org/W2120228339","https://openalex.org/W2127182681","https://openalex.org/W2128633866","https://openalex.org/W2129528230","https://openalex.org/W2131380293","https://openalex.org/W2132165605","https://openalex.org/W2134331961","https://openalex.org/W2135340140","https://openalex.org/W2138883403","https://openalex.org/W2141793702","https://openalex.org/W2142674699","https://openalex.org/W2144288812","https://openalex.org/W2144489715","https://openalex.org/W2144575734","https://openalex.org/W2144648093","https://openalex.org/W2144925128","https://openalex.org/W2146456530","https://openalex.org/W2147622823","https://openalex.org/W2147958437","https://openalex.org/W2149686779","https://openalex.org/W2151172917","https://openalex.org/W2152571442","https://openalex.org/W2152589533","https://openalex.org/W2152682803","https://openalex.org/W2153184502","https://openalex.org/W2154294326","https://openalex.org/W2158534725","https://openalex.org/W2158759790","https://openalex.org/W2159233773","https://openalex.org/W2159279278","https://openalex.org/W2159316366","https://openalex.org/W2162102234","https://openalex.org/W2162198402","https://openalex.org/W2162943132","https://openalex.org/W2163865122","https://openalex.org/W2164354029","https://openalex.org/W2167972746","https://openalex.org/W2168083679","https://openalex.org/W2168988227","https://openalex.org/W2169330106","https://openalex.org/W2170156489","https://openalex.org/W2171366623","https://openalex.org/W2171909092","https://openalex.org/W2171960002","https://openalex.org/W2335980015","https://openalex.org/W2409154349"],"related_works":["https://openalex.org/W2045613228","https://openalex.org/W2113011035","https://openalex.org/W183616322","https://openalex.org/W2059488879","https://openalex.org/W4283757610","https://openalex.org/W2107956705","https://openalex.org/W2033242380","https://openalex.org/W2149108024","https://openalex.org/W4240585467","https://openalex.org/W3185766400"],"abstract_inverted_index":{"Ghrelin":[0],"is":[1,27,144,167],"a":[2,22,45,74],"gastrointestinal":[3],"hormone":[4],"that":[5,26,65,93,122,139,158,217,240],"activates":[6],"the":[7,30,36,49,79,111,116,128,159,178,230,234,250,257],"ghrelin":[8,37,40,56,60,77,94,117,143,181,235],"receptor":[9],"(GHSR)":[10],"in":[11,85,88,127,183,233,243],"hypothalamic":[12],"neurons":[13],"to":[14,29,91,132,156,191,225,252,276],"promote":[15],"feeding":[16],"and":[17,52,87,103,124,153,172,186,198,214,281],"peripheral":[18],"lipid":[19],"storage.Ghrelin":[20],"contains":[21],"unique":[23],"acyl":[24,55],"modification":[25],"esterified":[28],"peptide":[31,118],"molecule.The":[32],"recent":[33],"discovery":[34],"of":[35,48,54,115,142,146,161,180,203,229,256],"acylating":[38],"enzyme,":[39],"O-acyltransferase":[41],"(GOAT),":[42],"has":[43],"provided":[44],"deeper":[46],"understanding":[47],"acylation":[50,148,182],"process":[51],"actions":[53],"(AG)":[57],"versus":[58],"des-acyl":[59],"(dAG).Our":[61],"group":[62],"previously":[63],"demonstrated":[64],"GOAT":[66,165],"utilizes":[67],"various":[68],"dietary":[69],"fatty":[70],"acids":[71],"(FAs)":[72],"as":[73,244],"substrate":[75],"for":[76,201,266],"acylation.In":[78],"current":[80],"study,":[81],"we":[82,120,150],"use":[83],"both":[84,210],"vitro":[86],"vivo":[89],"approaches":[90,155],"demonstrate":[92,157],"action":[95,166],"on":[96,169,272],"GHSR":[97],"activation,":[98],"food":[99],"intake,":[100],"body":[101],"weight":[102],"fat":[104],"mass":[105],"can":[106],"be":[107],"modified":[108],"by":[109,164],"altering":[110],"FA":[112],"side-chain":[113],"length":[114],"molecule.Additionally,":[119],"find":[121],"AG":[123],"dAG":[125],"act":[126],"central":[129],"nervous":[130],"system":[131],"increase":[133],"glucose-stimulated":[134],"plasma":[135],"insulin":[136],"levels":[137],"indicating":[138],"this":[140],"function":[141,179],"independent":[145],"its":[147],"state.Finally,":[149],"combine":[151],"genetic":[152],"pharmacological":[154],"regulation":[160],"glucose":[162,187],"tolerance":[163],"dependent":[168],"calorie":[170],"restriction":[171],"age.Collectively,":[173],"these":[174],"data":[175],"systematically":[176],"dissect":[177],"regulating":[184],"energy":[185],"metabolism.I":[188],"would":[189],"like":[190],"thank":[192],"my":[193,207,245,279],"thesis":[194],"mentors,":[195],"Matthias":[196,248],"Tsch\u00f6p":[197],"Randy":[199],"Seeley,":[200],"all":[202,255],"their":[204],"guidance":[205],"during":[206],"graduate":[208],"studies.You":[209],"have":[211],"exceptional":[212],"speaking":[213],"writing":[215],"skills":[216],"I":[218,221,237,263,274,282],"truly":[219],"admire.Matthias,":[220],"feel":[222],"very":[223],"privileged":[224],"work":[226],"with":[227,278],"one":[228],"top":[231],"researchers":[232],"field.Randy,":[236],"am":[238,283],"glad":[239],"you":[241,259],"stepped":[242],"mentor":[246],"when":[247,262],"moved":[249],"lab":[251],"Germany.I":[253],"appreciate":[254],"advice":[258],"gave":[260],"me":[261,270],"was":[264],"searching":[265],"post-doc":[267],"positions.You":[268],"helped":[269],"reflect":[271],"what":[273],"wanted":[275],"do":[277],"career":[280],"so":[284],"happy":[285]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
