{"id":"https://openalex.org/W2307684450","doi":null,"title":"The Role of Caspase-8 in Oligodendrocyte Development and Mechanisms of Oxidative Injury in Neurons and Glia","display_name":"The Role of Caspase-8 in Oligodendrocyte Development and Mechanisms of Oxidative Injury in Neurons and Glia","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2307684450","mag":"2307684450"},"language":"en","primary_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/148320","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/148320","pdf_url":"https://hdl.handle.net/1969.1/148320","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1969.1/148320","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108655221","display_name":"Jeffrey Thompson","orcid":"https://orcid.org/0000-0002-4012-5698","observed_orcids":["https://orcid.org/0000-0002-4012-5698"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108655221"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":1.0},{"id":"https://openalex.org/keywords/oligodendrocyte-apoptosis","display_name":"oligodendrocyte apoptosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oligodendrocyte-development","display_name":"oligodendrocyte development","score":0.8700000047683716},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.8360000252723694},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8259999752044678},{"id":"https://openalex.org/keywords/necrostatin-1","display_name":"necrostatin-1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/12-lipoxygenase","display_name":"12-lipoxygenase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/zinc-release","display_name":"zinc ion release","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tpen","display_name":"TPEN","score":0.7850000262260437},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.9409999847412109},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.7523735761642456},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5144662857055664},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.451936811208725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.383075475692749},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3399346172809601},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2462095022201538},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.19877934455871582},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10588312149047852}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/148320","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/148320","pdf_url":"https://hdl.handle.net/1969.1/148320","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2307684450","doi":null,"is_oa":false,"landing_page_url":"http://oaktrust.library.tamu.edu/handle/1969.1/148320","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:oaktrust.library.tamu.edu:1969.1/148320","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1969.1/148320","pdf_url":"https://hdl.handle.net/1969.1/148320","source":{"id":"https://openalex.org/S4306400291","display_name":"OakTrust (Texas A&M University Libraries)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91045830","host_organization_name":"Texas A&M University","host_organization_lineage":["https://openalex.org/I91045830"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2307684450.pdf","grobid_xml":"https://content.openalex.org/works/W2307684450.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1490480018","https://openalex.org/W1515333831","https://openalex.org/W1531415074","https://openalex.org/W1562558820","https://openalex.org/W1969323641","https://openalex.org/W1969455784","https://openalex.org/W1976984647","https://openalex.org/W1980286364","https://openalex.org/W1983078635","https://openalex.org/W1985915754","https://openalex.org/W1988038062","https://openalex.org/W1990474842","https://openalex.org/W1992272763","https://openalex.org/W1993097534","https://openalex.org/W2002979560","https://openalex.org/W2004522799","https://openalex.org/W2009692606","https://openalex.org/W2022767998","https://openalex.org/W2029552699","https://openalex.org/W2032037407","https://openalex.org/W2032154466","https://openalex.org/W2033968700","https://openalex.org/W2035605035","https://openalex.org/W2036158708","https://openalex.org/W2037279364","https://openalex.org/W2039355845","https://openalex.org/W2043413246","https://openalex.org/W2059783305","https://openalex.org/W2069334549","https://openalex.org/W2070620348","https://openalex.org/W2073356861","https://openalex.org/W2076184221","https://openalex.org/W2076363547","https://openalex.org/W2081560586","https://openalex.org/W2082624222","https://openalex.org/W2083140708","https://openalex.org/W2083560313","https://openalex.org/W2088793021","https://openalex.org/W2090177945","https://openalex.org/W2101861123","https://openalex.org/W2104704429","https://openalex.org/W2110796758","https://openalex.org/W2111755398","https://openalex.org/W2115967857","https://openalex.org/W2117088742","https://openalex.org/W2126553490","https://openalex.org/W2137280919","https://openalex.org/W2158662692","https://openalex.org/W2158748165","https://openalex.org/W2162184782","https://openalex.org/W2170901098","https://openalex.org/W2175835252","https://openalex.org/W2188067471","https://openalex.org/W2318621969","https://openalex.org/W2948665150"],"related_works":["https://openalex.org/W112514051","https://openalex.org/W2147946206","https://openalex.org/W2022083973","https://openalex.org/W351463991","https://openalex.org/W2056110778","https://openalex.org/W1986767133","https://openalex.org/W1989474113","https://openalex.org/W1922531502","https://openalex.org/W1971010029","https://openalex.org/W2011642986"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1],"essential":[2],"not":[3,79,179,200],"only":[4],"to":[5,24,43,61,126,147,211],"the":[6,16,28,89,107,120,159,207,228],"normal":[7],"development":[8],"of":[9,18,30,76,91,110,129,141,162,187,209,219],"a":[10,115,246],"multicellular":[11],"organism":[12],"but":[13,87,178,199],"also":[14,124],"for":[15,117],"maintenance":[17],"tissue":[19],"homeostasis.":[20],"This":[21],"proposal":[22],"seeks":[23,125],"investigate,":[25],"in":[26,34,47,53,68,85,103,106,119,132,152,174,180,225,237,255,262],"part,":[27],"role":[29,116],"oligodendrocyte":[31],"(OL)":[32],"apoptosis":[33],"myelination.":[35],"We":[36],"used":[37],"an":[38,101],"OL-specific":[39],"conditional":[40],"knockout":[41],"animal":[42],"study":[44,123],"caspase-8":[45,77,111,118],"function":[46],"OL":[48,62,81],"development;":[49],"analyzing":[50],"histological":[51],"differences":[52,254],"myelination":[54,121],"at":[55],"postnatal":[56],"day":[57],"10":[58],"and":[59,65,135,145,155,176,190,197,265],"alterations":[60],"proliferation,":[63],"differentiation,":[64],"cell":[66,130,156,240,256],"death":[67,131,173,236,257],"culture.":[69],"Our":[70],"preliminary":[71],"data":[72],"suggests":[73],"that":[74,185],"deletion":[75],"did":[78],"alter":[80],"proliferation":[82],"or":[83],"differentiation":[84],"culture,":[86],"reduced":[88],"percentage":[90],"apoptotic":[92],"cells":[93],"following":[94,137,259],"nutrient":[95],"deprivation.":[96],"In":[97],"vivo,":[98],"we":[99,183,214],"found":[100,184,215],"increase":[102],"myelinated":[104],"axons":[105],"spinal":[108],"cord":[109],"deficient":[112],"mice,":[113],"indicating":[114],"process.\\n\\nThis":[122],"investigate":[127],"mechanisms":[128,258],"OLs,":[133,143,264],"astrocytes,":[134,144,177,263],"neurons":[136,146,201],"oxidative":[138,153,172,235,260],"injury.":[139],"Exposure":[140],"primary":[142],"arachidonic":[148],"acid":[149],"(AA)":[150],"resulted":[151],"stress":[154],"death.":[157],"Necrostation-1,":[158],"specific":[160],"inhibitor":[161],"receptor":[163],"interacting":[164],"protein":[165],"kinase":[166,193],"1":[167],"(RIP-1),":[168],"markedly":[169],"prevented":[170],"AA-induced":[171,234],"OLs":[175,196],"neurons.":[181,226,266],"Similarly,":[182],"blockade":[186],"12-lipoxygenase":[188],"(LOX)":[189],"c-Jun":[191],"N-terminal":[192],"(JNK)":[194],"protected":[195],"astrocytes":[198],"against":[202],"AA":[203],"toxicity.":[204],"Consistent":[205],"with":[206],"inability":[208],"necrostatin-1":[210],"rescue":[212],"neurons,":[213],"very":[216],"low":[217],"expression":[218],"RIP-1":[220],"as":[221,223,245],"well":[222],"RIP-3":[224],"Finally,":[227],"zinc":[229,243],"chelator":[230],"TPEN":[231],"effectively":[232],"abolished":[233],"all":[238],"three":[239],"types,":[241],"suggesting":[242],"release":[244],"common":[247],"mechanism.":[248],"Taken":[249],"together,":[250],"our":[251],"findings":[252],"indicate":[253],"injury":[261]},"counts_by_year":[],"updated_date":"2026-09-02T18:50:13.731487","created_date":"2016-06-24T00:00:00"}