{"id":"https://openalex.org/W2307601985","doi":"https://doi.org/10.1042/cs0520277","title":"Oxygen Affinity in Vivo and in Vitro in Chronic Ventilatory Failure","display_name":"Oxygen Affinity in Vivo and in Vitro in Chronic Ventilatory Failure","publication_year":1977,"publication_date":"1977-03-01","ids":{"openalex":"https://openalex.org/W2307601985","doi":"https://doi.org/10.1042/cs0520277","mag":"2307601985","pmid":"https://pubmed.ncbi.nlm.nih.gov/844259"},"language":"en","primary_location":{"id":"doi:10.1042/cs0520277","doi":"https://doi.org/10.1042/cs0520277","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0520277","pdf_url":null,"source":{"id":"https://openalex.org/S4210171595","display_name":"Clinical Science","issn_l":"0301-0538","issn":["0301-0538"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109222322","display_name":"P.M. Tweeddale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. M. Tweeddale","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109089720","display_name":"R. J. E. Leggett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. J. E. Leggett","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112402921","display_name":"D. C. Flenley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. C. Flenley","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3768,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52125786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"3","first_page":"277","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chronic-ventilatory-failure","display_name":"chronic ventilatory failure","score":0.9779999852180481},{"id":"https://openalex.org/keywords/erythrocyte-2-3-diphosphoglycerate","display_name":"erythrocyte 2,3-diphosphoglycerate","score":0.9049999713897705},{"id":"https://openalex.org/keywords/plasma-inorganic-phosphate","display_name":"plasma inorganic phosphate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.921999990940094},{"id":"https://openalex.org/keywords/plasma-ph","display_name":"plasma pH","score":0.7979999780654907},{"id":"https://openalex.org/keywords/arteriovenous-oxygen-difference","display_name":"arteriovenous oxygen difference","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oxygen-saturation","display_name":"oxygen saturation","score":0.48899999260902405},{"id":"https://openalex.org/keywords/carbon-dioxide-tension","display_name":"carbon dioxide tension","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8038084506988525},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.6913744211196899},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6067842841148376},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.5936421751976013},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5155391693115234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4606693983078003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3459927439689636},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.335948646068573},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32471704483032227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2396804392337799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22571530938148499},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004163","descriptor_name":"Diphosphoglyceric Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014797","descriptor_name":"Vital Capacity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs0520277","doi":"https://doi.org/10.1042/cs0520277","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0520277","pdf_url":null,"source":{"id":"https://openalex.org/S4210171595","display_name":"Clinical Science","issn_l":"0301-0538","issn":["0301-0538"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:844259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/844259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science and molecular medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320316838","display_name":"Kempe Foundation","ror":"https://ror.org/05vbwqf43"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1497890785","https://openalex.org/W1963822131","https://openalex.org/W1989006470","https://openalex.org/W1995738915","https://openalex.org/W2019583885","https://openalex.org/W2028912414","https://openalex.org/W2045096947","https://openalex.org/W2135325762","https://openalex.org/W2325449425","https://openalex.org/W2354012175","https://openalex.org/W2406379054","https://openalex.org/W2411226993","https://openalex.org/W2416631678","https://openalex.org/W2425642377","https://openalex.org/W2609586546","https://openalex.org/W2921813682"],"related_works":["https://openalex.org/W2025016744","https://openalex.org/W979043726","https://openalex.org/W2315516462","https://openalex.org/W2076617655","https://openalex.org/W312019180","https://openalex.org/W2442046197","https://openalex.org/W2165860359","https://openalex.org/W2020920505","https://openalex.org/W2231218259","https://openalex.org/W2032300984"],"abstract_inverted_index":{"1.":[0],"The":[1,86],"oxygen":[2,40,90,108,118,125],"affinity":[3,41,109,126],"in":[4,16,24,62,79,89,92,111,127,133],"vitro,":[5],"haematological":[6],"indices,":[7],"erythrocyte":[8],"2,3-diphosphoglycerate":[9],"and":[10,23,48,55,73,82,113,115,119],"plasma":[11,72],"inorganic":[12],"phosphate":[13,43],"were":[14,59],"determined":[15,110],"20":[17,25],"patients":[18,47,81],"with":[19,101],"chronic":[20],"ventilatory":[21],"failure":[22],"healthy":[26,49,83],"non-smokers":[27],"of":[28,45],"similar":[29,78],"age.":[30],"2.":[31],"No":[32],"significant":[33],"difference":[34,88],"was":[35,67,77],"observed":[36],"between":[37,71],"the":[38,46,52,63,105,131],"mean":[39,53],"or":[42],"concentrations":[44],"subjects":[50],"but":[51],"haemoglobin":[54],"packed":[56],"cell":[57],"volume":[58],"significantly":[60],"higher":[61],"patients.":[64],"3.":[65],"There":[66],"a":[68],"positive":[69],"correlation":[70],"intraerythrocytic":[74],"pH":[75],"which":[76],"both":[80],"subjects.":[84],"4.":[85],"arteriovenous":[87],"saturation":[91],"vivo":[93],"(directly":[94],"measured":[95],"at":[96],"cardiac":[97],"catheterization)":[98],"correlated":[99],"closely":[100],"that":[102,124],"calculated":[103],"from":[104],"individual":[106],"patient's":[107],"vitro":[112,128],"arterial":[114],"mixed":[116],"venous":[117],"carbon":[120],"dioxide":[121],"tensions,":[122],"suggesting":[123],"accurately":[129],"reflects":[130],"curve":[132],"vivo.":[134]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}