{"id":"https://openalex.org/W2307199384","doi":"https://doi.org/10.1177/172460089000500205","title":"Significance of CA 72.4 Serum Levels in Gastrointestinal Diseases","display_name":"Significance of CA 72.4 Serum Levels in Gastrointestinal Diseases","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W2307199384","doi":"https://doi.org/10.1177/172460089000500205","mag":"2307199384","pmid":"https://pubmed.ncbi.nlm.nih.gov/2283481"},"language":"en","primary_location":{"id":"doi:10.1177/172460089000500205","doi":"https://doi.org/10.1177/172460089000500205","is_oa":false,"landing_page_url":"https://doi.org/10.1177/172460089000500205","pdf_url":null,"source":{"id":"https://openalex.org/S155339466","display_name":"The International Journal of Biological Markers","issn_l":"0393-6155","issn":["0393-6155","1724-6008"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biological Markers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003564325","display_name":"Paolo Piantino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Piantino","raw_affiliation_strings":["Departments of Gastroenterology and Torino - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gastroenterology and Torino - Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050889671","display_name":"Walter Taccone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Taccone","raw_affiliation_strings":["Analysis Laboratory, Civic Hospital of Avellino - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analysis Laboratory, Civic Hospital of Avellino - Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Fusaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Fusaro","raw_affiliation_strings":["Departments of Gastroenterology and Torino - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gastroenterology and Torino - Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088287511","display_name":"E Daziano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Daziano","raw_affiliation_strings":["Departments of Gastroenterology and Torino - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Gastroenterology and Torino - Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089223420","display_name":"Renato Polloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097265","display_name":"Azienda Ospedaliero Universitaria San Giovanni Battista","ror":"https://ror.org/00nrtez23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097265"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Polloni","raw_affiliation_strings":["Nuclear Medicine, S. Giovanni Battista Hospital, Torino - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, S. Giovanni Battista Hospital, Torino - Italy","institution_ids":["https://openalex.org/I4210097265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005058020","display_name":"Roberto Mosso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097265","display_name":"Azienda Ospedaliero Universitaria San Giovanni Battista","ror":"https://ror.org/00nrtez23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097265"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Mosso","raw_affiliation_strings":["Nuclear Medicine, S. Giovanni Battista Hospital, Torino - Italy","Analysis Laboratory, Civic Hospital of Avellino - Italy","Departments of Gastroenterology and Torino - Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, S. Giovanni Battista Hospital, Torino - Italy","institution_ids":["https://openalex.org/I4210097265"]},{"raw_affiliation_string":"Analysis Laboratory, Civic Hospital of Avellino - Italy","institution_ids":[]},{"raw_affiliation_string":"Departments of Gastroenterology and Torino - Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.2462,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56655666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"2","first_page":"77","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ca72-4","display_name":"CA72-4","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.753000020980835},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.6230000257492065},{"id":"https://openalex.org/keywords/atrophic-gastritis","display_name":"atrophic gastritis","score":1.0},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9769999980926514},{"id":"https://openalex.org/keywords/treatment-follow-up","display_name":"treatment follow-up","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7159192562103271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6897265911102295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6892387866973877},{"id":"https://openalex.org/C542804219","wikidata":"https://www.wikidata.org/wiki/Q5526839","display_name":"Gastrointestinal cancer","level":4,"score":0.6562487483024597},{"id":"https://openalex.org/C2780342937","wikidata":"https://www.wikidata.org/wiki/Q1826391","display_name":"Atrophic gastritis","level":4,"score":0.6150318384170532},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5592592358589172},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.5444756746292114},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.48001235723495483},{"id":"https://openalex.org/C144369459","wikidata":"https://www.wikidata.org/wiki/Q182517","display_name":"CA19-9","level":4,"score":0.43722856044769287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3301347494125366},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.28809940814971924},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10264098644256592},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.07065916061401367}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004066","descriptor_name":"Digestive System Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004067","descriptor_name":"Digestive System Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/172460089000500205","doi":"https://doi.org/10.1177/172460089000500205","is_oa":false,"landing_page_url":"https://doi.org/10.1177/172460089000500205","pdf_url":null,"source":{"id":"https://openalex.org/S155339466","display_name":"The International Journal of Biological Markers","issn_l":"0393-6155","issn":["0393-6155","1724-6008"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biological Markers","raw_type":"journal-article"},{"id":"pmid:2283481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2283481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of biological markers","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:243db1cc82c74ed5937106505ec0a54c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/243db1cc82c74ed5937106505ec0a54c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The International Journal of Biological Markers, Vol 5 (1990)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1977499361","https://openalex.org/W2031928907","https://openalex.org/W2060521474","https://openalex.org/W2073948680","https://openalex.org/W2084168547","https://openalex.org/W2096668339","https://openalex.org/W2103144075","https://openalex.org/W2134967094","https://openalex.org/W2145011046","https://openalex.org/W2155854805","https://openalex.org/W2410534589"],"related_works":["https://openalex.org/W1977499361","https://openalex.org/W2106262592","https://openalex.org/W2897913637","https://openalex.org/W3158832629","https://openalex.org/W2406503192","https://openalex.org/W3161369699","https://openalex.org/W1980117218","https://openalex.org/W2042903683","https://openalex.org/W2469774380","https://openalex.org/W2135092420"],"abstract_inverted_index":{"In":[0,78,155,173],"order":[1],"to":[2,96,137],"evaluate":[3],"the":[4,47,57,60,68,84,88,100,109,127,131,157],"usefulness":[5],"of":[6,59,108,130,144,151,160,177,180],"Ca":[7,43,85,122,132,149,181],"72.4":[8,44,86,133,182],"tumor":[9],"associated":[10],"antigen":[11],"assay":[12],"in":[13,54,62,170],"gastrointestinal":[14,112,139,164],"diseases,":[15],"we":[16],"have":[17],"studied":[18],"751":[19],"patients":[20,80],"suffering":[21],"from":[22,99],"benign":[23],"(376)":[24],"and":[25,30,67,73,117,121,148,153],"neoplastic":[26],"(375)":[27],"digestive":[28],"diseases":[29,140],"305":[31],"normal":[32],"controls.":[33],"The":[34,42,92],"cut-off":[35],"point":[36],"was":[37],"fixed":[38],"at":[39],"6":[40],"U/ml.":[41],"assay,":[45],"with":[46,81,135],"proposed":[48],"method,":[49],"provides":[50],"additional":[51],"information":[52],"only":[53,89],"gastric":[55,63,71,82],"cancers;":[56],"positivity":[58],"marker":[61,110,162],"neoplasms":[64,165],"is":[65,76,87,103],"38.4%":[66],"specificity":[69,129,145,159],"vs":[70,115,142],"ulcers":[72],"atrophic":[74],"gastritis":[75],"99%.":[77],"six":[79],"cancer,":[83],"positive":[90],"test.":[91],"most":[93],"striking":[94],"observation":[95],"be":[97,167,185],"made":[98],"current":[101],"study":[102],"a":[104],"no":[105],"good":[106],"sensitivity":[107],"for":[111,119,146,163],"cancers":[113],"(29.6%":[114],"35.7":[116],"37.6%":[118],"CEA":[120,147],"19-9":[123,150],"respectively),":[124],"but":[125],"rather":[126],"excellent":[128],"immunoassay":[134],"respect":[136],"being":[138],"(98.7%),":[141],"values":[143],"94":[152],"92%.":[154],"conclusion,":[156],"high":[158],"this":[161],"may":[166],"very":[168],"interesting":[169],"follow-up":[171],"studies.":[172],"fact,":[174],"an":[175],"elevation":[176],"serum":[178],"levels":[179],"should":[183],"always":[184],"taken":[186],"seriously.":[187]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}