{"id":"https://openalex.org/W2306136817","doi":null,"title":"Functional And Developmental Studies Of The Primate Testis","display_name":"Functional And Developmental Studies Of The Primate Testis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2306136817","mag":"2306136817"},"language":"en","primary_location":{"id":"pmh:oai:eprints.hec.gov.pk:490","doi":null,"is_oa":false,"landing_page_url":"http://eprints.hec.gov.pk/490/1/2937S.html","pdf_url":null,"source":{"id":"https://openalex.org/S4406922632","display_name":"HEC National Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033064460","display_name":"Shahzad Irfan","orcid":"https://orcid.org/0000-0003-3260-4215","observed_orcids":["https://orcid.org/0000-0003-3260-4215"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shahzad, Irfan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033064460"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kisspeptin-signaling","display_name":"kisspeptin signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/kiss1-receptor","display_name":"KISS1 receptor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/kiss1r","display_name":"KISS1R","score":0.6480000019073486},{"id":"https://openalex.org/keywords/kisspeptin","display_name":"kisspeptin","score":0.6830000281333923},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8870000243186951},{"id":"https://openalex.org/keywords/marmoset","display_name":"marmoset","score":0.8679999709129333},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.5270000100135803},{"id":"https://openalex.org/keywords/testicular-development","display_name":"testicular development","score":0.8700000047683716},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5260000228881836},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gnrh-antagonist","display_name":"GnRH antagonist","score":0.656000018119812},{"id":"https://openalex.org/keywords/acyline","display_name":"acyline","score":0.6930000185966492},{"id":"https://openalex.org/keywords/seminiferous-tubules","display_name":"seminiferous tubules","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2776453536","wikidata":"https://www.wikidata.org/wiki/Q19829485","display_name":"Marmoset","level":2,"score":0.9660003185272217},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.9135066270828247},{"id":"https://openalex.org/C2780509455","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Primate","level":2,"score":0.8105831742286682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7719175815582275},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6489396691322327},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.609541654586792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5928717255592346},{"id":"https://openalex.org/C2779504336","wikidata":"https://www.wikidata.org/wiki/Q1064620","display_name":"Callithrix","level":3,"score":0.5797306299209595},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.5605303645133972},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5277633666992188},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.4205775260925293},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3238663077354431},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1518700122833252},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13031965494155884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12358495593070984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:eprints.hec.gov.pk:490","doi":null,"is_oa":false,"landing_page_url":"http://eprints.hec.gov.pk/490/1/2937S.html","pdf_url":null,"source":{"id":"https://openalex.org/S4406922632","display_name":"HEC National Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1126555","https://openalex.org/W127650315","https://openalex.org/W1610882031","https://openalex.org/W1880891411","https://openalex.org/W1981960535","https://openalex.org/W1989225484","https://openalex.org/W1991384037","https://openalex.org/W2007967271","https://openalex.org/W2019501332","https://openalex.org/W2040226158","https://openalex.org/W2042572838","https://openalex.org/W2042710775","https://openalex.org/W2066964651","https://openalex.org/W2079320255","https://openalex.org/W2106930598","https://openalex.org/W2111338104","https://openalex.org/W2115983348","https://openalex.org/W2125090013","https://openalex.org/W2151613225","https://openalex.org/W2154715879","https://openalex.org/W2164194706","https://openalex.org/W2165193698","https://openalex.org/W2168643087","https://openalex.org/W2335488053"],"related_works":["https://openalex.org/W2298597477","https://openalex.org/W2004489427","https://openalex.org/W2344369613","https://openalex.org/W2068994547","https://openalex.org/W2483643783","https://openalex.org/W4286457063","https://openalex.org/W2097210968","https://openalex.org/W2782990410","https://openalex.org/W2030620540","https://openalex.org/W2476153558"],"abstract_inverted_index":{"Primate":[0],"testis":[1,27,63,105,173,195,206,236,251,340,360,443,517,592],"acts":[2],"as":[3,28,30,64,66,90,278],"the":[4,12,21,31,50,69,96,103,153,161,214,242,245,272,294,301,318,321,325,343,353,357,367,373,383,386,390,397,413,442,449,456,471,484,497,512,527,541,559,564,577,583,587,608,620,626,636,645,664],"main":[5],"source":[6],"for":[7,184,209,224,230,257,333,667],"androgen":[8],"and":[9,52,71,83,136,146,148,179,238,250,255,265,403,427,606,652],"sperm":[10,500],"under":[11],"functional":[13,22,53,97],"regulation":[14,23],"of":[15,20,24,34,55,99,133,164,187,227,244,271,304,320,331,356,385,406,415,425,433,458,480,490,499,509,525,530,538,582,586,610,614,629,644,647],"pituitary":[16,287],"gonadotropins.":[17],"The":[18,44,307,362,461,492,545,580,641],"understanding":[19],"adult":[25,59,124,176,198,289,326,338,358,560],"primate":[26,62,91,104,561,591,660],"well":[29,65],"developmental":[32,642,669],"aspects":[33],"maturation":[35],"during":[36],"puberty":[37,648],"in":[38,58,74,102,106,123,152,233,286,324,337,352,396,418,441,455,474,483,501,511,540,558,590,655,676],"primates":[39],"is":[40,556],"still":[41],"not":[42],"complete.":[43],"present":[45,316,351,371,381,546,557],"thesis":[46],"aimed":[47],"to":[48,67,349,467,520,598,624,672],"assess":[49],"localization":[51,163,186,309,332,369],"significance":[54,98],"kisspeptin":[56,100,134,137,165,188,344,391,565,588,615],"signaling":[57,101,555,631],"non":[60],"human":[61],"characterize":[68,213],"pubertal":[70,215,416,450,650],"testicular":[72,162,185,216,531,653],"development":[73,654],"a":[75,225,438,453],"New":[76],"World":[77],"monkey.":[78],"Rhesus":[79],"macaque":[80],"(Macaca":[81],"mulatta)":[82],"common":[84,219,419,513,543,656,677],"marmoset":[85,180,220,339,420,514,657],"(Callithrix":[86],"jacchus)":[87],"were":[88,129,144,207,222,248,268,315,596],"employed":[89],"models.":[92],"To":[93,158,212],"sort":[94],"out":[95,160],"vivo":[107],"pharmacological":[108],"approach":[109],"was":[110,150,168,190,253,262,335,347,370,394,428,465,503,533],"used":[111,208],"by":[112,116,155,430,437,478,496],"employing":[113],"chemical":[114],"hypophysectomy":[115],"using":[117],"acyline":[118],"(a":[119],"GnRH":[120],"receptor":[121,166,554,589],"antagonist)":[122],"rhesus":[125,177,199,291,327,359],"monkeys":[126,292],"(n=4).":[127],"Animals":[128],"given":[130,277],"iv":[131],"boluses":[132],"(50\u00ecg)":[135,138],"with":[139],"hCG":[140],"(50IU).":[141],"Blood":[142],"samples":[143],"taken":[145],"testosterone":[147,285,435,476,569],"LH":[149],"analyzed":[151],"plasma":[154,284,305],"specific":[156],"RIAs.":[157],"find":[159],"immunocytochemistry":[167,189],"performed":[169,191],"on":[170,192,300,576,616],"paraffin":[171,193,258],"embedded":[172,194],"tissue":[174,196,252],"from":[175,197,204],"(n=2)":[178,182],"monkey":[181,200],"whereas":[183,293],"(n=2).":[201],"12":[202,507,523],"sections":[203],"each":[205],"immunocytochemical":[210,308],"analysis.":[211],"development,":[217],"immature":[218],"(n=48)":[221],"observed":[223,395,466,505],"period":[226],"13":[228],"months":[229,424,489,524],"monthly":[231],"changes":[232],"body":[234],"weight,":[235],"volume":[237,518],"serum":[239,434,475],"testosterone.":[240,306],"At":[241],"end":[243],"study":[246],"animals":[247],"sacrificed":[249],"collected":[254],"processed":[256],"embedding.":[259],"PAS":[260],"staining":[261],"conducted.":[263],"Histological":[264],"morphometric":[266],"data":[267],"determined.":[269],"Results":[270],"experiments":[273],"demonstrated":[274],"that":[275,311,366,412,448,549],"kisspeptin,":[276],"an":[279,550,573,611],"intravenous":[280],"bolus":[281,296],"enhanced":[282],"stimulated":[283,568],"clamped":[288],"male":[290,542],"same":[295],"had":[297],"no":[298],"effect":[299],"basal":[302],"levels":[303],"revealed":[310,365,447],"kiss1r":[312,334,368],"positive":[313,600],"areas":[314],"at":[317,382,535,635],"periphery":[319,384],"seminiferous":[322,387,459,485],"tubules":[323,486],"testis.":[328,515],"Same":[329],"pattern":[330],"found":[336,348,597],"tissue.":[341,361],"Whereas":[342],"like":[345,392,661],"immunoreactivity":[346,393],"be":[350,599,673],"interstitial":[354],"area":[355],"detailed":[363],"examination":[364],"around":[372,422,506],"spermatogonial":[374],"stem":[375],"cells":[376,402,595],"(A":[377],"spermatogonia)":[378],"which":[379],"are":[380,639],"tubules.":[388,460],"While":[389],"peritubular":[398],"myoid":[399],"cells,":[400],"Leydig":[401,578,617],"underlying":[404],"layers":[405],"basement":[407],"membrane.":[408],"Developmental":[409],"studies":[410],"showed":[411],"start":[414],"activation":[417,451,651],"occur":[421],"7":[423,488],"age":[426,510,539],"characterized":[429,495],"sudden":[431],"peaks":[432],"accompanied":[436],"rapid":[439],"increase":[440,473],"volume.":[444],"Morphometric":[445],"analysis":[446],"created":[452],"lumen":[454],"center":[457],"germ":[462],"cell":[463,618],"compliment":[464],"divide":[468],"mitotically":[469],"after":[470,487,522],"initial":[472],"depicted":[477],"presence":[479,498],"B":[481],"spermatogonia":[482],"age.":[491],"complete":[493],"spermatogenesis":[494],"epididymis":[502],"first":[504],"month":[508],"Although":[516,663],"continued":[519],"grow":[521],"age,":[526],"qualitative":[528],"maturity":[529],"functions":[532],"achieved":[534],"one":[536],"year":[537],"marmoset.":[544,678],"findings":[547],"implicate":[548],"active":[551],"paracrine":[552],"kisspeptin-kisspeptin":[553],"testis;":[562],"where":[563,593],"can":[566],"enhance":[567],"thus":[570],"hinting":[571],"towards":[572],"indirect":[574,612],"action":[575,613],"cell.":[579],"finding":[581],"tubular":[584],"immunolocalization":[585],"Sertoli":[594,621],"further":[601,633,674],"extends":[602],"our":[603],"in-vivo":[604],"results":[605],"affirms":[607],"assumption":[609],"via":[619],"cells.":[622],"However":[623],"understand":[625],"true":[627],"nature":[628],"this":[630],"cascade":[632],"investigations":[634],"cellular":[637],"level":[638],"required.":[640],"kinetics":[643],"process":[646],"including":[649],"mimics":[658],"higher":[659],"pattern.":[662],"endocrine":[665],"correlates":[666],"these":[668],"events":[670],"need":[671],"substantiated":[675]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
