{"id":"https://openalex.org/W2305484472","doi":"https://doi.org/10.1152/ajpheart.1984.247.2.h229","title":"Hemodynamic response to volume depletion in acutely uremic dogs","display_name":"Hemodynamic response to volume depletion in acutely uremic dogs","publication_year":1984,"publication_date":"1984-08-01","ids":{"openalex":"https://openalex.org/W2305484472","doi":"https://doi.org/10.1152/ajpheart.1984.247.2.h229","mag":"2305484472","pmid":"https://pubmed.ncbi.nlm.nih.gov/6380313"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1984.247.2.h229","doi":"https://doi.org/10.1152/ajpheart.1984.247.2.h229","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1984.247.2.h229","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082338248","display_name":"John T. Daugirdas","orcid":"https://orcid.org/0000-0002-0644-6842","observed_orcids":["https://orcid.org/0000-0002-0644-6842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. T. Daugirdas","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048913438","display_name":"Todd S. Ing","orcid":"https://orcid.org/0000-0002-6804-9260","observed_orcids":["https://orcid.org/0000-0002-6804-9260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. S. Ing","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. T. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. T. Chen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572193","display_name":"Robert E. Vestal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. E. Vestal","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042772507","display_name":"Joseph L. Izzo","orcid":"https://orcid.org/0000-0002-3570-8370","observed_orcids":["https://orcid.org/0000-0002-3570-8370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. Izzo","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109117171","display_name":"Jessie E. Hano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. E. Hano","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039773615","display_name":"Marija J. Noru\u0161is","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. J. Norusis","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4596,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82291133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"247","issue":"2","first_page":"H229","last_page":"H236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-uremia","display_name":"acute uremia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hypovolemia","display_name":"hypovolemia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ultrafiltration","display_name":"ultrafiltration","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hemodynamic-response","display_name":"hemodynamic response","score":0.9070000052452087},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9430000185966492},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.7710000276565552},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.75},{"id":"https://openalex.org/keywords/blood-viscosity","display_name":"blood viscosity","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6750367879867554},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.6424340009689331},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5780625343322754},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.5315943360328674},{"id":"https://openalex.org/C2776894844","wikidata":"https://www.wikidata.org/wiki/Q1197437","display_name":"Fissipedia","level":2,"score":0.5109166502952576},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.4936255216598511},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48216456174850464},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.47736573219299316},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4692901074886322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4544225037097931},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.45269304513931274},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.449463427066803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4328065514564514},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.42669248580932617},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.292039155960083},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2176426351070404},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011669","descriptor_name":"Pulmonary Wedge Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014462","descriptor_name":"Ultrafiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1984.247.2.h229","doi":"https://doi.org/10.1152/ajpheart.1984.247.2.h229","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1984.247.2.h229","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:6380313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6380313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2436210812","https://openalex.org/W310579027","https://openalex.org/W2415029616","https://openalex.org/W2086858807","https://openalex.org/W1990347284","https://openalex.org/W2417234887","https://openalex.org/W151192700","https://openalex.org/W2085684311","https://openalex.org/W2297788351","https://openalex.org/W2191799528"],"abstract_inverted_index":{"Hemodynamic":[0],"response":[1],"to":[2,31,199,208,235],"volume":[3,127,237],"depletion":[4,238],"by":[5],"isolated":[6,202],"ultrafiltration":[7,203],"was":[8,19,38,170],"compared":[9,180,205],"in":[10,40,50,103,118,146,150,167,172,224],"uremic":[11,42,104,120,130,152,174,195,226],"(U)":[12],"and":[13,75,112,131,159,201,206],"nonuremic":[14,51,132],"(N)":[15],"conscious":[16,227],"dogs.":[17,121],"Fluid":[18],"removed":[20],"at":[21],"a":[22],"constant":[23],"rate":[24,169],"until":[25],"mean":[26],"arterial":[27],"pressure":[28],"(MAP)":[29],"decreased":[30],"less":[32,57,187],"than":[33,49,58,188],"80":[34],"mmHg.":[35],"Initial":[36,60,106],"MAP":[37],"higher":[39,102,171],"the":[41,119,123,151,173],"dogs":[43],"[132":[44],"+/-":[45,54,65,73,84,95,177,184],"8.6":[46],"(SD)":[47],"mmHg]":[48],"controls":[52,182],"(106":[53],"12,":[55],"P":[56,186],"0.001).":[59],"cardiac":[61],"index":[62,80],"[U":[63],"4.97":[64],"0.831":[66],"X":[67,69,87,89,91],"min-1":[68],"m-2,":[70,92],"N":[71,93],"4.44":[72],"0.62]":[74],"total":[76],"peripheral":[77],"vascular":[78],"resistance":[79],"[(TPRI)":[81],"U":[82],"2,160":[83],"353":[85],"dyn":[86],"s":[88],"cm-5":[90],"1,976":[94],"420]":[96],"were":[97,116,163,204],"slightly,":[98],"but":[99],"not":[100,240],"significantly,":[101],"animals.":[105],"central":[107],"venous":[108],"pressure,":[109,111],"wedge":[110],"plasma":[113,147,160],"norepinephrine":[114,161],"level":[115],"greater":[117],"At":[122,154],"end":[124,155],"point":[125],"of":[126,138,194],"depletion,":[128],"both":[129],"animals":[133,175],"had":[134,217],"achieved":[135],"similar":[136],"levels":[137,162],"TPRI,":[139],"despite":[140,229],"greatly":[141],"attenuated":[142],"or":[143],"absent":[144],"increases":[145],"renin":[148],"activity":[149],"group.":[153],"point,":[156],"blood":[157,214],"volumes":[158],"comparable.":[164],"The":[165,220],"increase":[166],"pulse":[168],"(59":[176],"37":[178],"pulses/min)":[179],"with":[181],"(25":[183],"52,":[185],"0.05).":[189],"In":[190],"an":[191],"additional":[192],"group":[193],"dogs,":[196,228],"cardiovascular":[197],"responses":[198],"hemorrhage":[200],"found":[207],"be":[209],"similar,":[210],"after":[211],"allowance":[212],"for":[213],"viscosity":[215],"changes":[216],"been":[218],"made.":[219],"data":[221],"suggest":[222],"that":[223],"acutely":[225],"reduced":[230],"renin-angiotensin":[231],"responses,":[232],"hemodynamic":[233],"adaptation":[234],"rapid":[236],"is":[239],"impaired.":[241]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}