{"id":"https://openalex.org/W2304896147","doi":null,"title":"Solution structure and 5{prime}-intercalation of the polynuclear aromatic BP residue in a (+)-cis-anti-[BP]-N{sup 6}-dA adduct opposite dT in a DNA duplex","display_name":"Solution structure and 5{prime}-intercalation of the polynuclear aromatic BP residue in a (+)-cis-anti-[BP]-N{sup 6}-dA adduct opposite dT in a DNA duplex","publication_year":1996,"publication_date":"1996-12-31","ids":{"openalex":"https://openalex.org/W2304896147","mag":"2304896147"},"language":"en","primary_location":{"id":"mag:2304896147","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/538958","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008908290","display_name":"Bing\u2010Wei Mao","orcid":"https://orcid.org/0000-0002-9015-0162","observed_orcids":["https://orcid.org/0000-0002-9015-0162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing\u2010Wei Mao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9015-0162","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077706769","display_name":"Dinshaw J. Patel","orcid":"https://orcid.org/0000-0002-9779-7778","observed_orcids":["https://orcid.org/0000-0002-9779-7778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dinshaw J. Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9779-7778","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050084307","display_name":"Jimin Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jimin Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018460703","display_name":"Nicholas E. Geacintov","orcid":"https://orcid.org/0000-0002-7961-2231","observed_orcids":["https://orcid.org/0000-0002-7961-2231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas E. Geacintov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7961-2231","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045073997","display_name":"Suse B. Broyde","orcid":"https://orcid.org/0000-0002-3802-7511","observed_orcids":["https://orcid.org/0000-0002-3802-7511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suse Broyde","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3802-7511","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15871474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.75},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-solution-structure","display_name":"DNA solution structure","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.8167330622673035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7903149724006653},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7100853323936462},{"id":"https://openalex.org/C84403525","wikidata":"https://www.wikidata.org/wiki/Q1895685","display_name":"Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid","level":4,"score":0.6014031171798706},{"id":"https://openalex.org/C137824038","wikidata":"https://www.wikidata.org/wiki/Q175562","display_name":"Intercalation (chemistry)","level":2,"score":0.5272842049598694},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5165566205978394},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.48253580927848816},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4619057774543762},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4415281414985657},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0818522572517395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07391631603240967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2304896147","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/538958","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098299718","https://openalex.org/W4240854248","https://openalex.org/W2013570811","https://openalex.org/W2068893806","https://openalex.org/W2076091293","https://openalex.org/W2084788201","https://openalex.org/W4251693126","https://openalex.org/W2044294594","https://openalex.org/W2033355069","https://openalex.org/W2531220902"],"abstract_inverted_index":{"The":[0,67],"covalent":[1],"binding":[2],"of":[3,28,54,76,101],"anti-benzo[a]pyrene-7,8-dihydroxy-9,10-epoxide":[4],"(BPDE)":[5],"to":[6,12,49,73],"cellular":[7],"DNA":[8],"gives":[9],"rise":[10],"predominantly":[11],"WAG":[13],"and":[14,35,87,99,119],"N6-dA":[15],"adducts.":[16],"While":[17],"the":[18,25,38,51,55,63,74,77,83,102,110,115,125],"latter":[19],"are":[20],"formed":[21],"in":[22,62,94,109,114],"minor":[23,56],"proportions,":[24],"mutagenic":[26],"potential":[27],"these":[29],"BPDE-N6-dA":[30],"lesions":[31],"could":[32],"be":[33],"important":[34],"dependent":[36],"on":[37],"adduct":[39,58,112],"structure.":[40],"We":[41],"have":[42],"applied":[43],"a":[44,97],"combined":[45],"NMR-molecular":[46],"mechanics":[47],"approach":[48],"determine":[50],"solution":[52],"conformation":[53],"(+)-cis-anti-[BP]dA":[57],"positioned":[59],"opposite":[60],"dT":[61],"duplex":[64],"d(C1-T2-C3-T4-C5-[BP-A6]-C7-T8-T9-C10-":[65],"C11).d(G22-A21-G20-A19-G18-T17-G16-A15-A14-G14-G13-G12).":[66],"BP":[68],"ring":[69],"system":[70],"is":[71,92,121],"intercalated":[72],"5{prime}-side":[75],"[BP]dA6":[78],"lesion":[79],"site":[80],"without":[81],"disrupting":[82],"flanking":[84],"Watson-Crick":[85,103],"dC5.dG18":[86],"[BP]dA6.dT17":[88,104],"base":[89,105],"pairs.":[90],"This":[91],"achieved":[93],"part":[95],"by":[96],"buckling":[98],"propeller-twisting":[100],"pair,":[106],"as":[107],"observed":[108],"(+)-trans-anti-[BcPh-dA6.dT17]":[111],"(BcPh=benzo[c]phenanthrenyl)":[113],"same":[116],"sequence":[117],"context,":[118],"which":[120],"stereochemically":[122],"similar":[123],"at":[124],"linkage":[126],"site.":[127]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}