{"id":"https://openalex.org/W2304243732","doi":null,"title":"A biocompatible, heparin-binding polycation for the controlled delivery of growth factors","display_name":"A biocompatible, heparin-binding polycation for the controlled delivery of growth factors","publication_year":2009,"publication_date":"2009-04-06","ids":{"openalex":"https://openalex.org/W2304243732","mag":"2304243732"},"language":"en","primary_location":{"id":"pmh:oai:smartech.gatech.edu:1853/28145","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/28145","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017735716","display_name":"Blaine J. Zern","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Blaine J. Zern","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017735716"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5396000146865845,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-factor-delivery","display_name":"growth factor delivery","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.9160000085830688},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.6949999928474426},{"id":"https://openalex.org/keywords/heparin-binding-protein","display_name":"heparin-binding protein","score":0.7390000224113464},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.796999990940094},{"id":"https://openalex.org/keywords/protein-bioactivity","display_name":"protein bioactivity","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.9331782460212708},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.6161638498306274},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5319086909294128},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5007498264312744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4427911043167114},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3332681953907013},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.19266346096992493},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1749345064163208},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.12207278609275818}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:smartech.gatech.edu:1853/28145","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/28145","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2304243732","doi":null,"is_oa":false,"landing_page_url":"https://smartech.gatech.edu/bitstream/1853/28145/1/zern_blaine_j_200905_phd.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W20847613","https://openalex.org/W25713228","https://openalex.org/W1485721124","https://openalex.org/W1511815964","https://openalex.org/W1520821663","https://openalex.org/W1563445758","https://openalex.org/W1634979164","https://openalex.org/W1789957917","https://openalex.org/W1867012516","https://openalex.org/W1895129045","https://openalex.org/W1915870046","https://openalex.org/W1968279337","https://openalex.org/W1968441791","https://openalex.org/W1969990997","https://openalex.org/W1970525947","https://openalex.org/W1970812755","https://openalex.org/W1973043293","https://openalex.org/W1976095935","https://openalex.org/W1978584972","https://openalex.org/W1979519758","https://openalex.org/W1980042430","https://openalex.org/W1980414709","https://openalex.org/W1981304130","https://openalex.org/W1984729535","https://openalex.org/W1985469208","https://openalex.org/W1986727298","https://openalex.org/W1989726643","https://openalex.org/W1990323998","https://openalex.org/W1990369593","https://openalex.org/W1994054444","https://openalex.org/W1995827857","https://openalex.org/W1997664422","https://openalex.org/W1997993853","https://openalex.org/W2000200774","https://openalex.org/W2002266713","https://openalex.org/W2003181279","https://openalex.org/W2005591639","https://openalex.org/W2005748958","https://openalex.org/W2007651161","https://openalex.org/W2009187824","https://openalex.org/W2010655741","https://openalex.org/W2010922391","https://openalex.org/W2012395572","https://openalex.org/W2012774822","https://openalex.org/W2013546498","https://openalex.org/W2013818100","https://openalex.org/W2014865280","https://openalex.org/W2017952250","https://openalex.org/W2019023730","https://openalex.org/W2019038143","https://openalex.org/W2019876924","https://openalex.org/W2020250111","https://openalex.org/W2021287409","https://openalex.org/W2024139208","https://openalex.org/W2026027552","https://openalex.org/W2027459937","https://openalex.org/W2028184858","https://openalex.org/W2029787326","https://openalex.org/W2030360808","https://openalex.org/W2030862253","https://openalex.org/W2033021454","https://openalex.org/W2033083169","https://openalex.org/W2035045639","https://openalex.org/W2035500216","https://openalex.org/W2036557453","https://openalex.org/W2037810763","https://openalex.org/W2039208932","https://openalex.org/W2039577598","https://openalex.org/W2040306677","https://openalex.org/W2041426309","https://openalex.org/W2041874034","https://openalex.org/W2044241782","https://openalex.org/W2044524539","https://openalex.org/W2045672171","https://openalex.org/W2047832247","https://openalex.org/W2048256151","https://openalex.org/W2048680502","https://openalex.org/W2051158595","https://openalex.org/W2052098523","https://openalex.org/W2052759117","https://openalex.org/W2055162584","https://openalex.org/W2055463351","https://openalex.org/W2055816523","https://openalex.org/W2056475985","https://openalex.org/W2057410741","https://openalex.org/W2058384606","https://openalex.org/W2060700788","https://openalex.org/W2061497413","https://openalex.org/W2061940955","https://openalex.org/W2062135876","https://openalex.org/W2063033586","https://openalex.org/W2064813253","https://openalex.org/W2065334464","https://openalex.org/W2067361099","https://openalex.org/W2068103868","https://openalex.org/W2068577315","https://openalex.org/W2068700749","https://openalex.org/W2071188821","https://openalex.org/W2071749640","https://openalex.org/W2071842134","https://openalex.org/W2073151449","https://openalex.org/W2073420780","https://openalex.org/W2073795835","https://openalex.org/W2075255316","https://openalex.org/W2077364459","https://openalex.org/W2080430067","https://openalex.org/W2081221541","https://openalex.org/W2082413221","https://openalex.org/W2083624809","https://openalex.org/W2084610464","https://openalex.org/W2086069830","https://openalex.org/W2087772801","https://openalex.org/W2089689396","https://openalex.org/W2090380610","https://openalex.org/W2090990180","https://openalex.org/W2091091415","https://openalex.org/W2091669754","https://openalex.org/W2091940747","https://openalex.org/W2094420339","https://openalex.org/W2094457676","https://openalex.org/W2094655821","https://openalex.org/W2094714478","https://openalex.org/W2094971700","https://openalex.org/W2095170053","https://openalex.org/W2098298002","https://openalex.org/W2101621191","https://openalex.org/W2102047825","https://openalex.org/W2104309130","https://openalex.org/W2104845809","https://openalex.org/W2105437420","https://openalex.org/W2106628516","https://openalex.org/W2109193011","https://openalex.org/W2109795452","https://openalex.org/W2111217096","https://openalex.org/W2114918609","https://openalex.org/W2122965729","https://openalex.org/W2123650819","https://openalex.org/W2123717856","https://openalex.org/W2124488388","https://openalex.org/W2124926420","https://openalex.org/W2130805719","https://openalex.org/W2131192673","https://openalex.org/W2133346775","https://openalex.org/W2138392373","https://openalex.org/W2142250399","https://openalex.org/W2143658931","https://openalex.org/W2144026946","https://openalex.org/W2153222771","https://openalex.org/W2154157809","https://openalex.org/W2160979129","https://openalex.org/W2162206996","https://openalex.org/W2162482990","https://openalex.org/W2163371839","https://openalex.org/W2163926528","https://openalex.org/W2164481110","https://openalex.org/W2169257419","https://openalex.org/W2171443849","https://openalex.org/W2408875021","https://openalex.org/W2787023214","https://openalex.org/W2916392902"],"related_works":["https://openalex.org/W2077996870","https://openalex.org/W2023969602","https://openalex.org/W2153979245","https://openalex.org/W605652976","https://openalex.org/W2054705904","https://openalex.org/W2071018626","https://openalex.org/W2751992247","https://openalex.org/W4234723500","https://openalex.org/W2057232665","https://openalex.org/W2996512031"],"abstract_inverted_index":{"The":[0,14,78,154],"delivery":[1,93,218,235,253,268],"of":[2,11,16,58,65,81,140,183,231,266,282,299,316],"growth":[3,19,41,96,125,212,232],"factors":[4,20,97,126],"has":[5,237,246,289],"been":[6],"attempted":[7],"for":[8,54,95,228,250,313],"a":[9,22,63,91,99,109,117,167,225,251,256,263,297,311],"number":[10],"different":[12],"therapies.":[13],"approach":[15],"delivering":[17,47],"therapeutic":[18],"in":[21,71,163,166,221,273,276,296],"safe":[23],"and":[24,29,46,102,145,180,192,208,243,275,288],"efficient":[25],"manner":[26],"is":[27,84,200,262,305],"difficult":[28],"certain":[30],"criteria":[31,36,61,88,240],"should":[32],"be":[33,293],"met.":[34],"These":[35,60],"include:":[37],"binding":[38],"the":[39,120,137,143,148,161,181,184,204,217,239,248,267,290,314],"appropriate":[40],"factors,":[42],"maintaining":[43],"their":[44],"bioactivity,":[45],"these":[48,87],"proteins":[49],"with":[50,113,119,127,176],"controllable":[51,177],"release":[52,138,178,230],"kinetics":[53,139,179],"an":[55,128],"extended":[56],"period":[57],"time.":[59],"encompass":[62],"set":[64],"guidelines":[66],"that":[67,108,279],"hope":[68],"to":[69,85,115,122,173,194,202,206,292,308],"mimic":[70],"vivo":[72,277],"biological":[73],"events":[74],"such":[75],"as":[76,310],"neovascularization.":[77],"central":[79],"goal":[80],"this":[82,222,244],"thesis":[83],"meet":[86],"by":[89,135,159],"introducing":[90],"novel":[92,226],"strategy":[94,236],"using":[98],"biocompatible":[100,257,318],"polycation":[101,110,258,271],"heparin.":[103],"\\n":[104,214],"\\nIt":[105],"was":[106,133,157,171,187,259,280],"hypothesized":[107],"could":[111],"interact":[112],"heparin":[114,195],"form":[116],"complex":[118,144,156],"potential":[121,291],"deliver":[123,174,209],"bioactive":[124],"adaptable":[129],"release.":[130],"This":[131,169,198,234,270,302],"hypothesis":[132],"tested":[134],"examining":[136],"bFGF":[141,150,175,186,191],"from":[142],"investigating":[146],"whether":[147],"released":[149,185],"maintained":[151],"its":[152],"bioactivity.":[153],"[polycation:heparin:bFGF]":[155],"formed":[158],"mixing":[160],"components":[162],"water,":[164],"resulting":[165],"precipitate.":[168],"precipitate":[170],"able":[172],"bioactivity":[182],"higher":[188,284],"than":[189,285],"bolus":[190],"comparable":[193],"stabilized":[196],"bFGF.":[197],"system":[199,219],"expected":[201,307],"have":[203],"ability":[205],"bind":[207],"numerous":[210],"heparin-binding":[211],"factors.":[213,233],"\\nIn":[215],"conclusion,":[216],"developed":[220],"research":[223,245],"provides":[224],"mechanism":[227],"controlled":[229],"met":[238],"listed":[241],"earlier":[242],"laid":[247],"foundation":[249],"successful":[252],"vehicle.":[254],"Further,":[255],"synthesized,":[260],"which":[261],"critical":[264],"component":[265],"system.":[269],"exhibited":[272],"vitro":[274],"biocompatibility":[278],"orders":[281],"magnitude":[283],"existing":[286],"polycations":[287],"very":[294],"useful":[295],"variety":[298],"biomedical":[300],"applications.":[301],"design":[303],"principle":[304],"also":[306],"serve":[309],"platform":[312],"synthesis":[315],"other":[317],"polycations.":[319]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}