{"id":"https://openalex.org/W2303526882","doi":"https://doi.org/10.4049/jimmunol.184.supp.93.28","title":"T cells, but not TLRs, control Act1-driven autoimmunity (93.28)","display_name":"T cells, but not TLRs, control Act1-driven autoimmunity (93.28)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2303526882","doi":"https://doi.org/10.4049/jimmunol.184.supp.93.28","mag":"2303526882"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.93.28","doi":"https://doi.org/10.4049/jimmunol.184.supp.93.28","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.93.28","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Angela Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Johnson","raw_affiliation_strings":["Immunology, Cleveland Clinic Foundation , Cleveland, OH","1Immunology, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Cleveland Clinic Foundation , Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"1Immunology, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":["Immunology, Cleveland Clinic Foundation , Cleveland, OH","1Immunology, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Cleveland Clinic Foundation , Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"1Immunology, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087308396","display_name":"Trine N. J\u00f8rgensen","orcid":"https://orcid.org/0000-0001-8566-4647","observed_orcids":["https://orcid.org/0000-0001-8566-4647"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trine Jorgensen","raw_affiliation_strings":["Immunology, Cleveland Clinic Foundation , Cleveland, OH","1Immunology, Cleveland Clinic Foundation, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Cleveland Clinic Foundation , Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"1Immunology, Cleveland Clinic Foundation, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"93.28","last_page":"93.28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/act1","display_name":"Act1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.8659999966621399},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/irak4","display_name":"IRAK4","score":0.9900000095367432},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/transitional-b-cells","display_name":"transitional B cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cd40-signaling","display_name":"CD40 signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8109999895095825},{"id":"https://openalex.org/keywords/immune-complex-deposition","display_name":"immune complex deposition","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hypergammaglobulinemia","display_name":"hypergammaglobulinemia","score":0.847000002861023},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7269999980926514},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.7718738317489624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6411154270172119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5815259218215942},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4842505156993866},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48069244623184204},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.45737767219543457},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4560404419898987},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4532212018966675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.448546826839447},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41560328006744385},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.23393100500106812},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.22678431868553162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05206054449081421},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.93.28","doi":"https://doi.org/10.4049/jimmunol.184.supp.93.28","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.93.28","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1865091334","https://openalex.org/W2086669881","https://openalex.org/W2149941295","https://openalex.org/W1985679359","https://openalex.org/W2047865956","https://openalex.org/W1538039325","https://openalex.org/W2588396304","https://openalex.org/W3081975357","https://openalex.org/W2035915920","https://openalex.org/W2011685756"],"abstract_inverted_index":{"Abstract":[0],"Act1":[1,64,91,100],"is":[2,15,121,167,183],"a":[3,16],"negative":[4],"regulator":[5],"of":[6,19,27,126,135,147,173,179,190,197],"B":[7,128,151,164,181],"lymphocyte-activating":[8],"factor":[9],"(BAFF)":[10],"and":[11,14,36,83,199],"CD40":[12],"signaling":[13,38,57],"key":[17],"modulator":[18],"systemic":[20],"autoimmunity,":[21],"since":[22],"Act1-deficient":[23],"mice":[24,46,96],"develop":[25],"symptoms":[26],"severe":[28],"autoimmune":[29,44],"disease.":[30],"As":[31],"both":[32,189],"T":[33,51,108,148,174,186],"cell":[34,139,165],"help":[35],"TLR":[37,56,74,201],"are":[39,70,87,113,130,153],"known":[40,122],"to":[41,43,194],"contribute":[42],"disease,":[45],"deficient":[47,95,104],"in":[48,72,90,99,132,144,156],"either":[49],"functional":[50,136],"cells":[52,109,129,152,182],"(TCRb/d":[53],"knockout)":[54,59],"or":[55],"(IRAK4":[58],"were":[60],"crossed":[61],"onto":[62],"the":[63,124,133,145,171,177],"autoimmune-prone":[65],"background.":[66],"Importantly,":[67],"IRAK4-deficient":[68],"animals":[69],"devoid":[71],"all":[73,88],"signaling,":[75],"except":[76],"TLR3.":[77],"Splenomegaly,":[78],"lymphademopathy,":[79],"hypergammaglobulinemia,":[80],"antigen-specific":[81],"autoantibodies":[82],"immune":[84],"complex":[85],"deposition":[86],"reduced":[89],"/":[92,101],"TCRb/d":[93],"triple":[94],"but":[97,110],"not":[98,111,168],"IRAK4":[102,198],"double":[103],"mice,":[105],"indicating":[106],"that":[107,123,143,162],"TLRs":[112],"required":[114],"for":[115],"Act1-driven":[116],"autoimmunity.":[117],"Additionally,":[118],"as":[119],"it":[120],"numbers":[125],"transitional":[127,150],"increased":[131,155],"absence":[134,146],"Act1,":[137],"preliminary":[138],"population":[140],"analysis":[141],"demonstrates":[142],"cells,":[149],"still":[154],"number.":[157],"Taken":[158],"together,":[159],"this":[160],"indicates":[161],"early":[163],"development":[166],"dependent":[169,184],"upon":[170,185],"presence":[172],"cells;":[175],"whereas,":[176],"activation":[178],"autoreactive":[180],"cells.":[187],"Furthermore,":[188],"these":[191],"events":[192],"appear":[193],"be":[195],"independent":[196],"potentially":[200],"signaling.":[202]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
