{"id":"https://openalex.org/W2302788557","doi":null,"title":"A guide to low molecular weight GTPases.","display_name":"A guide to low molecular weight GTPases.","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W2302788557","mag":"2302788557","pmid":"https://pubmed.ncbi.nlm.nih.gov/2150754"},"language":"en","primary_location":{"id":"pmid:2150754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2150754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020381827","display_name":"Sanders Da","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D A Sanders","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142","institution_ids":["https://openalex.org/I4210157710"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142#TAB#","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020381827"],"corresponding_institution_ids":["https://openalex.org/I4210157710"],"apc_list":null,"apc_paid":null,"fwci":1.0767,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73714286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"5","first_page":"251","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gtp-hydrolysis","display_name":"GTP hydrolysis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gdp-binding","display_name":"GDP binding","score":0.6039999723434448},{"id":"https://openalex.org/keywords/conserved-residues","display_name":"conserved residues","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ras-proteins","display_name":"Ras proteins","score":0.6140000224113464},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.5540000200271606},{"id":"https://openalex.org/keywords/magnesium-ions","display_name":"magnesium ions","score":0.32199999690055847},{"id":"https://openalex.org/keywords/mutation-analysis","display_name":"mutation analysis","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.9297729730606079},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.7941101789474487},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.783338189125061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6765992641448975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.600214421749115},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5392796397209167},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.5326682329177856},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.510436475276947},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.5054409503936768},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4899443984031677},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.454306423664093},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43177276849746704},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.43013402819633484},{"id":"https://openalex.org/C2779817904","wikidata":"https://www.wikidata.org/wiki/Q422582","display_name":"Guanosine diphosphate","level":5,"score":0.4162765443325043},{"id":"https://openalex.org/C2776638253","wikidata":"https://www.wikidata.org/wiki/Q392227","display_name":"Guanosine triphosphate","level":4,"score":0.31526684761047363},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21395769715309143},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1523168385028839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1396518051624298}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020743","descriptor_name":"rhoB GTP-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2150754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2150754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2302788557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2150754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W15581435","https://openalex.org/W73875301","https://openalex.org/W129191972","https://openalex.org/W148696575","https://openalex.org/W195338151","https://openalex.org/W196495617","https://openalex.org/W962563956","https://openalex.org/W1482512718","https://openalex.org/W1500411229","https://openalex.org/W1506293995","https://openalex.org/W1507437210","https://openalex.org/W1508018835","https://openalex.org/W1513979636","https://openalex.org/W1515291359","https://openalex.org/W1517753349","https://openalex.org/W1519439704","https://openalex.org/W1520904574","https://openalex.org/W1536335250","https://openalex.org/W1536858827","https://openalex.org/W1536988626","https://openalex.org/W1549883618","https://openalex.org/W1552158310","https://openalex.org/W1553247575","https://openalex.org/W1558802435","https://openalex.org/W1561770236","https://openalex.org/W1568345151","https://openalex.org/W1588094863","https://openalex.org/W1598368675","https://openalex.org/W1605851497","https://openalex.org/W1639281802","https://openalex.org/W1657138111","https://openalex.org/W1666400257","https://openalex.org/W1681931564","https://openalex.org/W1749375214","https://openalex.org/W1750765805","https://openalex.org/W1752162927","https://openalex.org/W1783564364","https://openalex.org/W1794163232","https://openalex.org/W1819297632","https://openalex.org/W1835109348","https://openalex.org/W1842672419","https://openalex.org/W1858393860","https://openalex.org/W1859718968","https://openalex.org/W1869481189","https://openalex.org/W1880291900","https://openalex.org/W1886849485","https://openalex.org/W1887642177","https://openalex.org/W1896109150","https://openalex.org/W1938497882","https://openalex.org/W1940081151","https://openalex.org/W1945627345","https://openalex.org/W1948476464","https://openalex.org/W1964201498","https://openalex.org/W1966426311","https://openalex.org/W1966683022","https://openalex.org/W1967452306","https://openalex.org/W1975702028","https://openalex.org/W1979527189","https://openalex.org/W1979646488","https://openalex.org/W1980234539","https://openalex.org/W1982710998","https://openalex.org/W1984789478","https://openalex.org/W1985700603","https://openalex.org/W1986383101","https://openalex.org/W1986409528","https://openalex.org/W1987325795","https://openalex.org/W1988181486","https://openalex.org/W1988718915","https://openalex.org/W1988970153","https://openalex.org/W1989009382","https://openalex.org/W1993972454","https://openalex.org/W1994331967","https://openalex.org/W1998023125","https://openalex.org/W1998132110","https://openalex.org/W1999275756","https://openalex.org/W2002299218","https://openalex.org/W2003267467","https://openalex.org/W2008014792","https://openalex.org/W2010488494","https://openalex.org/W2011377286","https://openalex.org/W2012806962","https://openalex.org/W2013026243","https://openalex.org/W2014356084","https://openalex.org/W2014656185","https://openalex.org/W2015391676","https://openalex.org/W2020358132","https://openalex.org/W2022213176","https://openalex.org/W2022638591","https://openalex.org/W2026070941","https://openalex.org/W2028519621","https://openalex.org/W2032923234","https://openalex.org/W2035363409","https://openalex.org/W2039725258","https://openalex.org/W2046484554","https://openalex.org/W2046955948","https://openalex.org/W2046961979","https://openalex.org/W2048784760","https://openalex.org/W2051156045","https://openalex.org/W2056786827","https://openalex.org/W2056857208","https://openalex.org/W2057163724","https://openalex.org/W2057385958","https://openalex.org/W2058491704","https://openalex.org/W2058511768","https://openalex.org/W2058649415","https://openalex.org/W2060032114","https://openalex.org/W2060169580","https://openalex.org/W2060242664","https://openalex.org/W2061019978","https://openalex.org/W2061906765","https://openalex.org/W2065951262","https://openalex.org/W2070633164","https://openalex.org/W2073828165","https://openalex.org/W2075122403","https://openalex.org/W2075564766","https://openalex.org/W2075612889","https://openalex.org/W2075869274","https://openalex.org/W2077286276","https://openalex.org/W2078792023","https://openalex.org/W2081446575","https://openalex.org/W2084663419","https://openalex.org/W2089082472","https://openalex.org/W2089108869","https://openalex.org/W2089741493","https://openalex.org/W2090702802","https://openalex.org/W2092226164","https://openalex.org/W2092727362","https://openalex.org/W2093081532","https://openalex.org/W2103762486","https://openalex.org/W2105843437","https://openalex.org/W2120425861","https://openalex.org/W2124902513","https://openalex.org/W2128748400","https://openalex.org/W2130116578","https://openalex.org/W2133362776","https://openalex.org/W2136461541","https://openalex.org/W2136757745","https://openalex.org/W2137359064","https://openalex.org/W2138007390","https://openalex.org/W2138917208","https://openalex.org/W2143907613","https://openalex.org/W2144217770","https://openalex.org/W2155832793","https://openalex.org/W2158608327","https://openalex.org/W2158726454","https://openalex.org/W2159601127","https://openalex.org/W2162479263","https://openalex.org/W2167875305","https://openalex.org/W2308783294","https://openalex.org/W2321031632","https://openalex.org/W2327875936","https://openalex.org/W2397292236","https://openalex.org/W2805995684"],"related_works":["https://openalex.org/W2950611434","https://openalex.org/W2031178514","https://openalex.org/W6976794049","https://openalex.org/W2285497332","https://openalex.org/W2114460420","https://openalex.org/W7095175728","https://openalex.org/W2519399262","https://openalex.org/W2099152045","https://openalex.org/W2122028042","https://openalex.org/W2051728948"],"abstract_inverted_index":{"An":[0],"increasing":[1],"number":[2,160],"of":[3,21,26,34,42,64,89,115,123,127,130,153,161,181,198,203,209,244,265,291,307,315,323,328,341,353,358],"biological":[4,234],"processes":[5],"have":[6],"been":[7],"shown":[8],"to":[9,47,72,136,230,299,333],"be":[10,48,70,134],"regulated":[11],"by":[12,168,218,255],"proteins":[13,131,157],"that":[14,100,110,132],"bind":[15,185],"and":[16,184,201,228,257,349],"hydrolyze":[17],"GTP.":[18,324,354],"The":[19,118,156,195,240,279,288,325,355],"sequence":[20,296],"the":[22,39,55,112,116,124,146,165,186,207,215,219,231,245,252,266,284,295,300,303,308,311,321,329,338,342,347,351,359,366],"presumed":[23,149],"active":[24,82],"site":[25,126],"GTP":[27,106,183,199],"hydrolysis":[28,68,180,200],"is":[29,96,283,294],"highly":[30],"conserved":[31,119,220,267],"in":[32,54,92,105,141,224,272,346],"most":[33],"these":[35,43,154,169,225],"proteins,":[36],"and,":[37],"therefore,":[38,94],"three-dimensional":[40],"structures":[41,53,166],"sites":[44],"are":[45,101,139,205],"likely":[46],"congruent":[49],"as":[50,77,137],"well.":[51],"Homologous":[52],"GTPase":[56],"domains":[57],"do":[58],"not,":[59],"however,":[60],"indicate":[61],"a":[62,128,159,175,260],"similarity":[63],"physiological":[65],"function.":[66],"Nucleotide":[67],"may":[69],"coupled":[71],"any":[73],"energy-requiring":[74],"process,":[75],"such":[76],"macromolecular":[78],"or":[79,86,148,362],"organeliar":[80],"movement,":[81],"transport":[83],"across":[84],"membranes,":[85],"allosteric":[87],"regulation":[88],"protein":[90,247],"activity.":[91],"general,":[93],"it":[95],"amino":[97,120,221,268,313],"acid":[98,121,222,269],"sequences":[99,122,170],"not":[102],"directly":[103],"involved":[104],"utilization":[107],"per":[108],"se":[109],"dictate":[111],"biochemical":[113],"role":[114],"GTPases.":[117],"GTPaseactive":[125],"family":[129],"will":[133],"referred":[135],"lmgs2":[138],"listed":[140],"Table":[142,273],"1":[143,274,276,277],"along":[144],"with":[145,189,251,320,337,350],"known":[147],"functions":[150,227],"for":[151],"some":[152],"proteins.":[155],"share":[158],"properties":[162],"resulting":[163],"from":[164],"formed":[167],"(Table":[171,238],"2):":[172],"they":[173],"catalyze":[174],"slow":[176],"intrinsic":[177,196],"magnesium":[178],"ion-dependent":[179],"bound":[182],"product":[187],"GDP":[188,204],"high":[190],"affinity":[191],"(submicromolar":[192],"dissociation":[193,202],"constants).":[194],"rates":[197],"on":[206],"order":[208],"0.01/mm.":[210],"Mutational":[211],"analysis":[212],"has":[213],"elucidated":[214],"parts":[216],"played":[217],"residues":[223,270,345],"catalytic":[226],"contributed":[229],"discovery":[232],"ofthe":[233,236,263],"roles":[235,264],"GTPases":[237],"2).":[239],"X-ray":[241,301],"crystallographic":[242],"structure":[243],"ras":[246],"(a":[248],"six-stranded":[249],"fl-sheet":[250],"strands":[253],"linked":[254],"loops":[256],"a-helices)":[258],"provides":[259],"physical":[261],"description":[262],"noted":[271],"(77,":[275],"7-120).":[278],"first":[280,343],"element":[281],"(G-1)":[282],"fl-phosphoryl":[285],"binding":[286],"ioop.":[287],"central":[289],"region":[290],"this":[292,316],"loop":[293,348],"G-X-X-(A/G/S)-X-G-K-S/T.":[297],"According":[298],"structure,":[302],"main-chain":[304],"amide":[305],"hydrogens":[306],"fourth":[309],"through":[310],"seventh":[312],"acids":[314],"ioop":[317],"form":[318,334],"bonds":[319,336],"fl-phosphate":[322],"6-amino":[326],"group":[327],"lysmne":[330],"residue":[331,364],"appears":[332],"hydrogen":[335],"carbonyl":[339],"groups":[340],"two":[344],"#{176}y-phosphate":[352],"hydroxyl":[356],"oxygen":[357],"terminal":[360],"serine":[361],"threonine":[363],"binds":[365],"mag-":[367]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}