{"id":"https://openalex.org/W2302727183","doi":"https://doi.org/10.4049/jimmunol.184.supp.141.19","title":"Particulate Allergens Exacerbate Allergic Asthma via Extended Localization within Lipid Raft Enriched Compartments in Mast Cells (141.19)","display_name":"Particulate Allergens Exacerbate Allergic Asthma via Extended Localization within Lipid Raft Enriched Compartments in Mast Cells (141.19)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2302727183","doi":"https://doi.org/10.4049/jimmunol.184.supp.141.19","mag":"2302727183"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.141.19","doi":"https://doi.org/10.4049/jimmunol.184.supp.141.19","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.141.19","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111722014","display_name":"Cong Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cong Jin","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087100299","display_name":"Christopher P. Shelburne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Shelburne","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guojie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guojie Li","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067875096","display_name":"Erin N. Potts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Potts","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010820504","display_name":"Kristina J. Riebe","orcid":"https://orcid.org/0000-0003-4936-4756","observed_orcids":["https://orcid.org/0000-0003-4936-4756"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Riebe","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087681431","display_name":"Gregory D. Sempowski","orcid":"https://orcid.org/0000-0003-0391-6594","observed_orcids":["https://orcid.org/0000-0003-0391-6594"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Sempowski","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Foster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Foster","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030259389","display_name":"Soman N. Abraham","orcid":"https://orcid.org/0000-0002-1662-2096","observed_orcids":["https://orcid.org/0000-0002-1662-2096"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soman Abraham","raw_affiliation_strings":["Duke University , Durham, NC","1Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University , Durham, NC","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"1Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"141.19","last_page":"141.19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.09640000015497208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8420000076293945},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pulmonary-eosinophilia","display_name":"pulmonary eosinophilia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/polystyrene-microspheres","display_name":"polystyrene microspheres","score":0.722000002861023},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/pro-inflammatory-mediators","display_name":"pro-inflammatory mediators","score":0.8420000076293945},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6677651405334473},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6467478275299072},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5735771656036377},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5459572076797485},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.4874308407306671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47993308305740356},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.473110169172287},{"id":"https://openalex.org/C3020633164","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Allergic asthma","level":3,"score":0.4289509057998657},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.426936537027359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2608411908149719},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19791442155838013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10820135474205017},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09040305018424988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.141.19","doi":"https://doi.org/10.4049/jimmunol.184.supp.141.19","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.141.19","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977445502","https://openalex.org/W2106190669","https://openalex.org/W2169454490","https://openalex.org/W1586084288","https://openalex.org/W2911494219","https://openalex.org/W2149599159","https://openalex.org/W2939503150","https://openalex.org/W2513454721","https://openalex.org/W2062821382","https://openalex.org/W4387365451"],"abstract_inverted_index":{"Abstract":[0],"Numerous":[1],"epidemiological":[2],"studies":[3],"have":[4],"related":[5],"the":[6,21,119,173,177,188],"exacerbation":[7],"of":[8,58,108,122,128,167,176,180,190],"allergic":[9,29,41,92,191],"asthma":[10,30,42],"with":[11,50],"exposure":[12],"to":[13,46,55,84,101,110,116,153,187],"increased":[14],"ambient":[15],"particles":[16],"from":[17],"air":[18],"pollutants.":[19],"However,":[20,138],"mechanism":[22],"by":[23,43,141],"which":[24,158],"particulate":[25,178],"allergens":[26,181],"(pAg)":[27],"exacerbate":[28],"remains":[31],"undefined.":[32],"To":[33],"evaluate":[34],"this,":[35],"we":[36],"modeled":[37],"environmental":[38],"pAg":[39,63,111],"induced":[40],"exposing":[44],"mice":[45,99],"polystyrene":[47],"beads":[48],"coated":[49],"natural":[51],"allergen":[52,60,73],"extracts.":[53],"Compared":[54],"equal":[56],"amounts":[57],"soluble":[59],"extracts":[61],"(sAg),":[62],"triggered":[64],"markedly":[65],"enhanced":[66],"airway":[67,91],"hyper-responsiveness":[68],"and":[69,150,164,182],"pulmonary":[70],"eosinophila":[71],"in":[72,96,118,160],"sensitized":[74],"mice.":[75,104],"The":[76,105],"cellular":[77],"basis":[78],"for":[79],"this":[80],"effect":[81],"was":[82],"determined":[83],"be":[85],"mast":[86,183],"cells":[87],"(MCs),":[88],"as":[89],"both":[90],"responses":[93,107],"were":[94,114],"attenuated":[95],"MC":[97,102],"deficient":[98],"compared":[100],"sufficient":[103],"divergent":[106],"MCs":[109],"versus":[112],"sAg":[113],"due":[115],"differences":[117],"termination":[120],"rate":[121],"IgE/Fc\u03f5RI":[123,130,143],"initiated":[124],"signaling.":[125],"Following":[126],"ligation":[127,140],"sAg,":[129],"rapidly":[131],"shuttled":[132],"into":[133,145],"a":[134,155,161],"degradative":[135,156],"endosome/lysosome":[136],"pathway.":[137],"following":[139],"pAg,":[142],"migrated":[144],"lipid":[146],"raft":[147],"enriched":[148],"compartments":[149],"subsequently":[151],"failed":[152],"follow":[154],"pathway,":[157],"resulted":[159],"prolonged":[162],"signaling":[163],"heightened":[165],"synthesis":[166],"proinflammatory":[168],"mediators.":[169],"These":[170],"observations":[171],"highlight":[172],"overlooked":[174],"contributions":[175],"nature":[179],"cell":[184],"endocytic":[185],"circuitry":[186],"aggravation":[189],"asthma.":[192]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}