{"id":"https://openalex.org/W2302550167","doi":null,"title":"Intera\u00e7\u00f5es medicamentosas envolvendo contracetivos hormonais","display_name":"Intera\u00e7\u00f5es medicamentosas envolvendo contracetivos hormonais","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2302550167","mag":"2302550167"},"language":"pt","primary_location":{"id":"pmh:oai:sapientia.ualg.pt:10400.1/6882","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.1/6882","pdf_url":"http://hdl.handle.net/10400.1/6882","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.1/6882","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Martins, Silvana Agostinho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Martins, Silvana Agostinho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.19130000472068787,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hormonal-contraception","display_name":"hormonal contraception","score":0.9819999933242798},{"id":"https://openalex.org/keywords/oral-contraceptives","display_name":"oral contraceptives","score":0.984000027179718},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8550000190734863},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4790000021457672},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.7039999961853027},{"id":"https://openalex.org/keywords/phase-ii-metabolism","display_name":"phase II metabolism","score":0.578000009059906},{"id":"https://openalex.org/keywords/contraceptive-efficacy","display_name":"contraceptive efficacy","score":0.5680000185966492},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hypericin","display_name":"hypericin","score":0.6359999775886536},{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.7390000224113464},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.6650000214576721},{"id":"https://openalex.org/keywords/etoricoxib","display_name":"etoricoxib","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pharmacist-counseling","display_name":"pharmacist counseling","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3928535282611847}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:sapientia.ualg.pt:10400.1/6882","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.1/6882","pdf_url":"http://hdl.handle.net/10400.1/6882","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:sapientia.ualg.pt:10400.1/6882","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.1/6882","pdf_url":"http://hdl.handle.net/10400.1/6882","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2302550167.pdf","grobid_xml":"https://content.openalex.org/works/W2302550167.grobid-xml"},"referenced_works_count":195,"referenced_works":["https://openalex.org/W56092313","https://openalex.org/W96357402","https://openalex.org/W155747404","https://openalex.org/W645652010","https://openalex.org/W1542975637","https://openalex.org/W1548404106","https://openalex.org/W1566726772","https://openalex.org/W1568913878","https://openalex.org/W1575736774","https://openalex.org/W1581407744","https://openalex.org/W1587801042","https://openalex.org/W1596948422","https://openalex.org/W1606705306","https://openalex.org/W1753098306","https://openalex.org/W1756553517","https://openalex.org/W1771977177","https://openalex.org/W1794469725","https://openalex.org/W1940970798","https://openalex.org/W1963517446","https://openalex.org/W1967782384","https://openalex.org/W1968156085","https://openalex.org/W1969242985","https://openalex.org/W1970703128","https://openalex.org/W1971833400","https://openalex.org/W1973455550","https://openalex.org/W1975378193","https://openalex.org/W1975394942","https://openalex.org/W1976895985","https://openalex.org/W1977655549","https://openalex.org/W1977980607","https://openalex.org/W1978207949","https://openalex.org/W1978372501","https://openalex.org/W1978971095","https://openalex.org/W1979486893","https://openalex.org/W1980293674","https://openalex.org/W1981629940","https://openalex.org/W1982479090","https://openalex.org/W1982664182","https://openalex.org/W1985110387","https://openalex.org/W1987237337","https://openalex.org/W1990594056","https://openalex.org/W1990904235","https://openalex.org/W1991628398","https://openalex.org/W1993909919","https://openalex.org/W1994585702","https://openalex.org/W1997878568","https://openalex.org/W1998545834","https://openalex.org/W1999449749","https://openalex.org/W2000351383","https://openalex.org/W2000715578","https://openalex.org/W2002175782","https://openalex.org/W2004912101","https://openalex.org/W2005475888","https://openalex.org/W2005684334","https://openalex.org/W2009386434","https://openalex.org/W2009817985","https://openalex.org/W2010173222","https://openalex.org/W2011274867","https://openalex.org/W2011684453","https://openalex.org/W2014692644","https://openalex.org/W2014798300","https://openalex.org/W2015185599","https://openalex.org/W2015567783","https://openalex.org/W2015677019","https://openalex.org/W2022857932","https://openalex.org/W2024269229","https://openalex.org/W2027240748","https://openalex.org/W2028190791","https://openalex.org/W2028957187","https://openalex.org/W2030251436","https://openalex.org/W2031459387","https://openalex.org/W2031708651","https://openalex.org/W2031730012","https://openalex.org/W2031929091","https://openalex.org/W2032595866","https://openalex.org/W2035369081","https://openalex.org/W2037292769","https://openalex.org/W2037512793","https://openalex.org/W2037845030","https://openalex.org/W2039090728","https://openalex.org/W2040466901","https://openalex.org/W2041499894","https://openalex.org/W2041926443","https://openalex.org/W2043018530","https://openalex.org/W2043793079","https://openalex.org/W2044015363","https://openalex.org/W2047633964","https://openalex.org/W2048727294","https://openalex.org/W2049239232","https://openalex.org/W2049772989","https://openalex.org/W2050590444","https://openalex.org/W2051469662","https://openalex.org/W2055807403","https://openalex.org/W2056700496","https://openalex.org/W2057496117","https://openalex.org/W2058864601","https://openalex.org/W2059247032","https://openalex.org/W2059979713","https://openalex.org/W2061088592","https://openalex.org/W2061694345","https://openalex.org/W2063797559","https://openalex.org/W2068544716","https://openalex.org/W2068634821","https://openalex.org/W2069211894","https://openalex.org/W2069770781","https://openalex.org/W2069987842","https://openalex.org/W2070829073","https://openalex.org/W2071730519","https://openalex.org/W2072699625","https://openalex.org/W2072831812","https://openalex.org/W2072870423","https://openalex.org/W2073889366","https://openalex.org/W2074207016","https://openalex.org/W2074486762","https://openalex.org/W2076336531","https://openalex.org/W2076449998","https://openalex.org/W2076985436","https://openalex.org/W2077241317","https://openalex.org/W2078188718","https://openalex.org/W2078917293","https://openalex.org/W2079619305","https://openalex.org/W2079896267","https://openalex.org/W2081337864","https://openalex.org/W2082390876","https://openalex.org/W2083075058","https://openalex.org/W2083270733","https://openalex.org/W2083570314","https://openalex.org/W2083643730","https://openalex.org/W2085489841","https://openalex.org/W2088811688","https://openalex.org/W2091181249","https://openalex.org/W2092006882","https://openalex.org/W2092190477","https://openalex.org/W2092225831","https://openalex.org/W2092702393","https://openalex.org/W2094220317","https://openalex.org/W2094913630","https://openalex.org/W2096476698","https://openalex.org/W2096739998","https://openalex.org/W2096804993","https://openalex.org/W2097102749","https://openalex.org/W2097848864","https://openalex.org/W2100129751","https://openalex.org/W2100560126","https://openalex.org/W2101319348","https://openalex.org/W2104231345","https://openalex.org/W2105060143","https://openalex.org/W2109558038","https://openalex.org/W2110066130","https://openalex.org/W2110573486","https://openalex.org/W2112217588","https://openalex.org/W2113159773","https://openalex.org/W2116524580","https://openalex.org/W2119454367","https://openalex.org/W2126008785","https://openalex.org/W2127332237","https://openalex.org/W2129310064","https://openalex.org/W2129387415","https://openalex.org/W2131020156","https://openalex.org/W2131822813","https://openalex.org/W2132257746","https://openalex.org/W2133001403","https://openalex.org/W2135040276","https://openalex.org/W2137785069","https://openalex.org/W2139535214","https://openalex.org/W2141626898","https://openalex.org/W2142244531","https://openalex.org/W2142289262","https://openalex.org/W2145694963","https://openalex.org/W2148994299","https://openalex.org/W2149427794","https://openalex.org/W2149455951","https://openalex.org/W2152724566","https://openalex.org/W2154310483","https://openalex.org/W2154535037","https://openalex.org/W2155429440","https://openalex.org/W2159059200","https://openalex.org/W2159447233","https://openalex.org/W2160716066","https://openalex.org/W2162652559","https://openalex.org/W2164206878","https://openalex.org/W2165016043","https://openalex.org/W2167318643","https://openalex.org/W2168779932","https://openalex.org/W2169290209","https://openalex.org/W2170492741","https://openalex.org/W2185270343","https://openalex.org/W2197831775","https://openalex.org/W2258586660","https://openalex.org/W2324211119","https://openalex.org/W2324624882","https://openalex.org/W2325718923","https://openalex.org/W2399638302","https://openalex.org/W2409919975","https://openalex.org/W3111232738"],"related_works":["https://openalex.org/W6999431904","https://openalex.org/W2894143056","https://openalex.org/W7219407989","https://openalex.org/W7020736525","https://openalex.org/W2978570070","https://openalex.org/W4205342631","https://openalex.org/W7220398246","https://openalex.org/W2739020358","https://openalex.org/W6991887988","https://openalex.org/W4289551516"],"abstract_inverted_index":{"Em":[0],"Portugal,":[1],"segundo":[2],"o":[3,27,52,154,164,169,203,266],"4\u00ba":[4],"Inqu\u00e9rito":[5],"Nacional":[6],"de":[7,11,33,37,86,97,109,126,198,211,215,224,245,247,272,295],"Sa\u00fade":[8],"(2009),":[9],"cerca":[10],"85%":[12],"da":[13,122,143,189,205],"popula\u00e7\u00e3o":[14,67],"feminina":[15],"em":[16,133,192,277,287],"idade":[17,278],"f\u00e9rtil":[18,279],"usa":[19],"um":[20,38,138,281,283],"m\u00e9todo":[21,28],"contracetivo,":[22],"sendo":[23],"os":[24,60,90,106,230,270],"contracetivos":[25,61,146,179,231,248],"orais":[26],"hormonal":[29],"mais":[30],"popular":[31],"(cerca":[32],"66%).":[34],"Os":[35,111],"efeitos":[36,199],"medicamento,":[39],"quando":[40],"administrado":[41,55],"concomitantemente":[42],"com":[43,148,229],"outros":[44,82],"medicamentos,":[45],"podem":[46,75,117],"ser":[47,118],"diferentes":[48],"dos":[49,114,130,145,156,178,238],"esperados":[50],"caso":[51,155,204],"medicamento":[53],"fosse":[54],"sozinho.":[56],"Uma":[57],"vez":[58],"que":[59,74,183,220,226],"hormonais":[62,147,249],"s\u00e3o":[63,105],"largamente":[64],"utilizados":[65],"pela":[66],"feminina,":[68],"torna-se":[69],"necess\u00e1rio":[70],"averiguar":[71],"as":[72,275],"intera\u00e7\u00f5es":[73,98,257],"ocorrer":[76],"entre":[77,269],"esta":[78],"classe":[79],"farmacol\u00f3gica":[80],"e":[81,104,129,159,171,213,217,264,274,291],"f\u00e1rmacos.":[83],"As":[84],"enzimas":[85],"fase":[87,127],"I,":[88],"nomeadamente":[89],"CYP,":[91],"est\u00e3o":[92],"muito":[93],"envolvidos":[94],"na":[95],"ocorr\u00eancia":[96,197],"farmacocin\u00e9ticas,":[99],"pois":[100],"t\u00eam":[101],"muitos":[102],"substratos":[103],"principais":[107],"metabolizadores":[108],"xenobi\u00f3ticos.":[110],"par\u00e2metros":[112],"farmacocin\u00e9ticos":[113],"f\u00e1rmacos":[115,225],"tamb\u00e9m":[116,282],"influenciados":[119],"ao":[120,181],"n\u00edvel":[121],"absor\u00e7\u00e3o,":[123],"do":[124,160],"metabolismo":[125],"II":[128],"transportadores.":[131],"Enquanto":[132],"alguns":[134],"casos":[135,163],"n\u00e3o":[136],"existe":[137],"impacto":[139],"cl\u00ednico":[140,166],"significativo":[141],"resultante":[142],"intera\u00e7\u00e3o":[144],"outras":[149],"classes":[150],"farmacol\u00f3gicas,":[151],"como":[152],"\u00e9":[153,167,202,234,280],"bloqueadores":[157],"\u03b2":[158],"etoricoxib,":[161],"noutros":[162],"efeito":[165],"comprometido;":[168],"hiperic\u00e3o":[170],"a":[172,175,186,196,209,222,243,285],"rifampicina":[173],"influenciam":[174],"efic\u00e1cia":[176,187],"contracetiva":[177],"hormonais,":[180],"passo":[182],"estes":[184],"diminuem":[185],"terap\u00eautica":[188],"lamotrigina":[190],"(resultando":[191],"convuls\u00f5es)":[193],"ou":[194],"potenciam":[195],"adversos":[200],"(como":[201],"clopromazina).":[206],"Torna-se":[207],"necess\u00e1ria":[208],"ado\u00e7\u00e3o":[210],"mecanismos":[212],"protocolos":[214],"prescri\u00e7\u00e3o":[216,251],"aconselhamento":[218],"m\u00e9dico":[219],"minimizem":[221],"co-prescri\u00e7\u00e3o":[223],"possam":[227],"interagir":[228],"hormonais.":[232],"Adicionalmente,":[233],"preciso":[235],"uma":[236],"consciencializa\u00e7\u00e3o":[237],"profissionais":[239,271],"das":[240,256],"farm\u00e1cias":[241],"para":[242,289],"leviandade":[244],"dispensa":[246],"sem":[250],"m\u00e9dica.":[252],"Um":[253],"bom":[254],"conhecimento":[255],"medicamentosas":[258],"leva":[259],"\u00e0":[260],"sua":[261],"dete\u00e7\u00e3o,":[262],"avalia\u00e7\u00e3o":[263],"impedimento;":[265],"maior":[267],"contacto":[268],"sa\u00fade":[273],"mulheres":[276],"fator":[284],"ter":[286],"contar":[288],"evitar":[290],"resolver":[292],"este":[293],"tipo":[294],"situa\u00e7\u00f5es.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
