{"id":"https://openalex.org/W2302309747","doi":"https://doi.org/10.4137/cmo.s34534","title":"Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer","display_name":"Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2302309747","doi":"https://doi.org/10.4137/cmo.s34534","mag":"2302309747","pmid":"https://pubmed.ncbi.nlm.nih.gov/27013902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4798019"},"language":"en","primary_location":{"id":"doi:10.4137/cmo.s34534","doi":"https://doi.org/10.4137/cmo.s34534","is_oa":true,"landing_page_url":"https://doi.org/10.4137/cmo.s34534","pdf_url":null,"source":{"id":"https://openalex.org/S1031084011","display_name":"Clinical Medicine Insights Oncology","issn_l":"1179-5549","issn":["1179-5549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine Insights: Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4137/cmo.s34534","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018645768","display_name":"Emmanuel S. Antonarakis","orcid":"https://orcid.org/0000-0003-0031-9655","observed_orcids":["https://orcid.org/0000-0003-0031-9655","https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Antonarakis","raw_affiliation_strings":["Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108116218","display_name":"Karim Boudadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karim Boudadi","raw_affiliation_strings":["Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":5.8312,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.97259227,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10s1","issue":"Suppl 1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antiandrogen-resistance","display_name":"antiandrogen resistance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9399999976158142},{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":1.0},{"id":"https://openalex.org/keywords/androgen-receptor-signaling","display_name":"androgen receptor signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cyp17","display_name":"CYP17","score":0.8450000286102295},{"id":"https://openalex.org/keywords/ar-splice-variants","display_name":"androgen receptor splice variants","score":0.8730000257492065},{"id":"https://openalex.org/keywords/androgen-receptor-mutations","display_name":"androgen receptor mutations","score":0.7580000162124634},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neuroendocrine-transformation","display_name":"neuroendocrine transformation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.746999979019165},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.9721794724464417},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8223487138748169},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7659076452255249},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7426443099975586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5429461002349854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5412736535072327},{"id":"https://openalex.org/C2775832370","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone acetate","level":5,"score":0.5184899568557739},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.45400238037109375},{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.4534462094306946},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.37088626623153687},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3585912585258484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32209500670433044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30413609743118286},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11301633715629578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.4137/cmo.s34534","doi":"https://doi.org/10.4137/cmo.s34534","is_oa":true,"landing_page_url":"https://doi.org/10.4137/cmo.s34534","pdf_url":null,"source":{"id":"https://openalex.org/S1031084011","display_name":"Clinical Medicine Insights Oncology","issn_l":"1179-5549","issn":["1179-5549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine Insights: Oncology","raw_type":"journal-article"},{"id":"doi:10.4137/cmo.ss34534","doi":"https://doi.org/10.4137/cmo.ss34534","is_oa":true,"landing_page_url":"https://doi.org/10.4137/cmo.ss34534","pdf_url":"https://journals.sagepub.com/doi/pdf/10.4137/CMO.Ss34534","source":{"id":"https://openalex.org/S1031084011","display_name":"Clinical Medicine Insights Oncology","issn_l":"1179-5549","issn":["1179-5549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine Insights: Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4798019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4798019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Med Insights Oncol","raw_type":"Text"},{"id":"pmid:27013902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27013902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine Insights. Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:861535af7a1b48209a4a06e648b9c84f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/861535af7a1b48209a4a06e648b9c84f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Medicine Insights: Oncology, Vol 10s1 (2016)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bc44f323177444f4847975522721aa22","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bc44f323177444f4847975522721aa22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Medicine Insights: Oncology, Vol 2016, Iss Suppl. 1, Pp 1-9 (2016)","raw_type":"article"},{"id":"pmh:oai:libertasacademica.com/5468","doi":null,"is_oa":false,"landing_page_url":"http://insights.sagepub.com/redirect_file.php?fileId=7304&filename=5468-CMO-Resistance-to-Novel-Antiandrogen-Therapies-in-Metastatic-Castration-Re.pdf&fileType=pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://insights.sagepub.com/resistance-to-novel-antiandrogen-therapies-in-metastatic-castration-re-article-a5468","raw_type":null}],"best_oa_location":{"id":"doi:10.4137/cmo.s34534","doi":"https://doi.org/10.4137/cmo.s34534","is_oa":true,"landing_page_url":"https://doi.org/10.4137/cmo.s34534","pdf_url":null,"source":{"id":"https://openalex.org/S1031084011","display_name":"Clinical Medicine Insights Oncology","issn_l":"1179-5549","issn":["1179-5549"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Medicine Insights: Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5977839230","display_name":null,"funder_award_id":"P30 CA006973","funder_id":"https://openalex.org/F4320306163","funder_display_name":"Prostate Cancer Foundation"},{"id":"https://openalex.org/G8159508589","display_name":"The aberrant androgen receptor underlies abiraterone/enzalutamide resistance","funder_award_id":"R01CA185297","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320312140","display_name":"Exelixis","ror":"https://ror.org/01e3jga91"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2302309747.pdf"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1578291413","https://openalex.org/W1580150455","https://openalex.org/W1582446028","https://openalex.org/W1755643198","https://openalex.org/W1827081793","https://openalex.org/W1920614447","https://openalex.org/W1925305957","https://openalex.org/W1948931726","https://openalex.org/W1969916602","https://openalex.org/W1972969589","https://openalex.org/W1995039837","https://openalex.org/W1999343166","https://openalex.org/W2000460499","https://openalex.org/W2006352011","https://openalex.org/W2006382528","https://openalex.org/W2009402948","https://openalex.org/W2010072924","https://openalex.org/W2014751188","https://openalex.org/W2023400202","https://openalex.org/W2024432096","https://openalex.org/W2031454470","https://openalex.org/W2034235423","https://openalex.org/W2036006424","https://openalex.org/W2041997083","https://openalex.org/W2051025382","https://openalex.org/W2055655957","https://openalex.org/W2067312336","https://openalex.org/W2073100248","https://openalex.org/W2077863736","https://openalex.org/W2079688281","https://openalex.org/W2080748037","https://openalex.org/W2085847636","https://openalex.org/W2088318211","https://openalex.org/W2095873383","https://openalex.org/W2097226696","https://openalex.org/W2097984421","https://openalex.org/W2107633226","https://openalex.org/W2110534364","https://openalex.org/W2117686639","https://openalex.org/W2117857186","https://openalex.org/W2118906905","https://openalex.org/W2119504728","https://openalex.org/W2121098984","https://openalex.org/W2121640179","https://openalex.org/W2121846636","https://openalex.org/W2124831348","https://openalex.org/W2130189600","https://openalex.org/W2130955565","https://openalex.org/W2134988422","https://openalex.org/W2137467802","https://openalex.org/W2137974207","https://openalex.org/W2138504446","https://openalex.org/W2142008762","https://openalex.org/W2144110960","https://openalex.org/W2145777186","https://openalex.org/W2148643283","https://openalex.org/W2150039609","https://openalex.org/W2152631280","https://openalex.org/W2156571397","https://openalex.org/W2156923287","https://openalex.org/W2157980218","https://openalex.org/W2159575889","https://openalex.org/W2160463964","https://openalex.org/W2160975559","https://openalex.org/W2161879447","https://openalex.org/W2165782799","https://openalex.org/W2166324735","https://openalex.org/W2166912270","https://openalex.org/W2167749314","https://openalex.org/W2170544517","https://openalex.org/W2170552969","https://openalex.org/W2171041379","https://openalex.org/W2318692321","https://openalex.org/W2340799873","https://openalex.org/W2587831721","https://openalex.org/W2604912531","https://openalex.org/W2768197275","https://openalex.org/W4322700960"],"related_works":["https://openalex.org/W1745328274","https://openalex.org/W1634543743","https://openalex.org/W2622254362","https://openalex.org/W2013982033","https://openalex.org/W1962442902","https://openalex.org/W2784463194","https://openalex.org/W2113899328","https://openalex.org/W2044287047","https://openalex.org/W2074990730","https://openalex.org/W2613775504"],"abstract_inverted_index":{"Despite":[0],"the":[1,30,59,124],"introduction":[2],"of":[3,32,43,61,72,81,89,97,101,118,129],"novel":[4,132],"therapies":[5],"that":[6],"maximally":[7],"decrease":[8],"androgen-receptor":[9],"(AR)":[10],"signaling":[11,104],"activity,":[12],"metastatic":[13],"castration-resistant":[14],"prostate":[15],"cancer":[16],"(mCRPC)":[17],"remains":[18],"a":[19,40],"lethal":[20],"disease.":[21],"Even":[22],"though":[23],"abiraterone":[24],"and":[25,34,51,74,83,108,140],"enzalutamide":[26,139],"represent":[27],"breakthroughs":[28],"in":[29],"treatment":[31],"mCRPC":[33],"have":[35,45],"demonstrated":[36],"significant":[37,41],"survival":[38],"benefits,":[39],"proportion":[42],"patients":[44,54],"primary":[46],"resistance":[47,62,130],"to":[48,63,122,131],"these":[49,64],"agents":[50,65],"virtually":[52],"all":[53],"develop":[55],"secondary":[56],"resistance.":[57],"While":[58],"mechanisms":[60,76,128],"are":[66,77],"not":[67],"fully":[68],"understood,":[69],"many":[70],"hypotheses":[71],"AR-dependent":[73],"AR-independent":[75],"emerging,":[78],"including":[79],"upregulation":[80,96],"AR":[82,90,93],"cytochrome":[84],"P450":[85],"17\u03b1-hydroxylase/17,20-lyase":[86],"(CYP17),":[87],"induction":[88],"splice":[91],"variants,":[92],"point":[94],"mutations,":[95],"glucocorticoid":[98],"receptor,":[99],"activation":[100],"alternative":[102],"oncogenic":[103],"pathways,":[105],"neuroendocrine":[106],"transformation,":[107],"immune":[109],"evasion":[110],"via":[111],"programmed":[112],"death-ligand":[113],"1":[114],"upregulation.":[115],"The":[116],"aim":[117],"this":[119],"review":[120],"is":[121],"summarize":[123],"most":[125],"clinically":[126],"relevant":[127],"androgen-directed":[133],"agents,":[134],"focusing":[135],"on":[136],"escape":[137],"from":[138],"abiraterone.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}