{"id":"https://openalex.org/W2302139152","doi":"https://doi.org/10.1152/jappl.1976.41.3.396","title":"Localization of airway constriction using gases of varying density and viscosity","display_name":"Localization of airway constriction using gases of varying density and viscosity","publication_year":1976,"publication_date":"1976-09-01","ids":{"openalex":"https://openalex.org/W2302139152","doi":"https://doi.org/10.1152/jappl.1976.41.3.396","mag":"2302139152","pmid":"https://pubmed.ncbi.nlm.nih.gov/965309"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1976.41.3.396","doi":"https://doi.org/10.1152/jappl.1976.41.3.396","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1976.41.3.396","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021045413","display_name":"Jeffrey M. Drazen","orcid":"https://orcid.org/0000-0003-2715-9890","observed_orcids":["https://orcid.org/0000-0003-2715-9890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. M. Drazen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054772138","display_name":"Stephen H. Loring","orcid":"https://orcid.org/0000-0002-6277-3979","observed_orcids":["https://orcid.org/0000-0002-6277-3979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. H. Loring","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025367098","display_name":"Roland H. Ingram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. H. Ingram","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7741,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76165302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"41","issue":"3","first_page":"396","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.34860000014305115,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.34860000014305115,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.3433000147342682,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-constriction","display_name":"airway constriction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pulmonary-resistance","display_name":"pulmonary resistance","score":0.8560000061988831},{"id":"https://openalex.org/keywords/gas-density","display_name":"gas density","score":0.7390000224113464},{"id":"https://openalex.org/keywords/gas-viscosity","display_name":"gas viscosity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/helium","display_name":"helium","score":0.7160000205039978},{"id":"https://openalex.org/keywords/sulfur-hexafluoride","display_name":"sulfur hexafluoride","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.5979999899864197},{"id":"https://openalex.org/keywords/forced-oscillations","display_name":"forced oscillations","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.8144458532333374},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.7237890362739563},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6455787420272827},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5618769526481628},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.5554889440536499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48256412148475647},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4565533995628357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32676616311073303},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23784136772155762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23012316226959229}],"mesh":[{"descriptor_ui":"D000403","descriptor_name":"Airway Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005740","descriptor_name":"Gases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006371","descriptor_name":"Helium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013455","descriptor_name":"Sulfur","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1976.41.3.396","doi":"https://doi.org/10.1152/jappl.1976.41.3.396","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1976.41.3.396","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:965309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/965309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1960703293","https://openalex.org/W2164159996","https://openalex.org/W2416250697","https://openalex.org/W2130404240","https://openalex.org/W2027745367","https://openalex.org/W2414708874","https://openalex.org/W2180680684","https://openalex.org/W2202174686","https://openalex.org/W6875111","https://openalex.org/W2409483018"],"abstract_inverted_index":{"The":[0],"relationship":[1],"between":[2],"the":[3,63,94,131],"major":[4],"site":[5,133],"of":[6,18,40,134],"airway":[7,34,95,142],"constriction":[8,136],"and":[9,21,37,71,97,116],"change":[10,119],"in":[11,25,85,103,106,120,123,148],"total":[12,149],"pulmonary":[13,41,49,150],"resistance":[14,42,50,89,114,151],"while":[15],"breathing":[16],"gases":[17],"varying":[19],"density":[20],"viscosity":[22],"was":[23,51],"studied":[24],"five":[26],"anesthetized":[27],"dogs":[28],"pretreated":[29],"with":[30,56,62,66,75],"atropine.":[31],"Using":[32],"an":[33],"catheter,":[35],"central":[36,113],"peripheral":[38,88],"components":[39],"were":[43],"measured":[44,52],"by":[45,93,144],"forced":[46],"oscillation.":[47],"Total":[48],"at":[53,59,72],"0.5":[54],"1/s":[55,61,74],"lungs":[57,64],"air-filled,":[58],"0.25":[60],"filled":[65],"80%":[67,76],"helium-20%":[68],"oxygen":[69,79],"(RL-He),":[70],"1.0":[73],"sulfur":[77],"hexafluoride-20%":[78],"(RL-SF6).":[80],"Intravenous":[81],"histamine":[82],"infusion":[83],"resulted":[84],"a":[86,98,111,117],"predominantly":[87],"increase":[90,102,115],"as":[91],"determined":[92,139],"catheter":[96,143],"much":[99],"larger":[100],"percentage":[101],"RL-He":[104],"than":[105,122],"RL-SF6.":[107],"Tracheal":[108],"banding":[109],"produced":[110],"purely":[112],"greater":[118],"RL-SF6":[121],"FL-He.":[124],"These":[125],"results":[126],"support":[127],"theoretical":[128],"predictions":[129],"that":[130],"predominant":[132],"airways":[135],"can":[137],"be":[138],"without":[140],"on":[141],"comparing":[145],"relative":[146],"changes":[147],"using":[152],"different":[153],"flow":[154],"regimes.":[155]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}