{"id":"https://openalex.org/W2302115779","doi":"https://doi.org/10.3389/fphar.2016.00032","title":"The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential","display_name":"The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential","publication_year":2016,"publication_date":"2016-03-04","ids":{"openalex":"https://openalex.org/W2302115779","doi":"https://doi.org/10.3389/fphar.2016.00032","mag":"2302115779","pmid":"https://pubmed.ncbi.nlm.nih.gov/26973522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4777733"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2016.00032","doi":"https://doi.org/10.3389/fphar.2016.00032","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2016.00032","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00032/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00032/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083538035","display_name":"Amandine Scandolera","orcid":"https://orcid.org/0000-0001-6403-1664","observed_orcids":["https://orcid.org/0000-0001-6403-1664"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amandine Scandolera","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021327147","display_name":"Ludivine Odoul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ludivine Odoul","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008760642","display_name":"St\u00e9phanie Salesse","orcid":"https://orcid.org/0009-0009-8450-7506","observed_orcids":["https://orcid.org/0009-0009-8450-7506"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Salesse","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026973286","display_name":"Alexandre Guillot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Guillot","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024743509","display_name":"S\u00e9bastien A. Blaise","orcid":"https://orcid.org/0000-0003-3012-1500","observed_orcids":["https://orcid.org/0000-0003-3012-1500"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Blaise","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084889670","display_name":"Charlotte Kawecki","orcid":"https://orcid.org/0000-0001-9126-6127","observed_orcids":["https://orcid.org/0000-0001-9126-6127"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charlotte Kawecki","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029908549","display_name":"Pascal Maurice","orcid":"https://orcid.org/0000-0003-2167-4808","observed_orcids":["https://orcid.org/0000-0003-2167-4808"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Maurice","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043464864","display_name":"Hassan El Btaouri","orcid":"https://orcid.org/0000-0003-3069-4798","observed_orcids":["https://orcid.org/0000-0003-3069-4798"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hassan El Btaouri","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020569095","display_name":"B\u00e9atrice Romier","orcid":"https://orcid.org/0000-0002-9065-3595","observed_orcids":["https://orcid.org/0000-0002-9065-3595"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B\u00e9atrice Romier-Crouzet","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041446063","display_name":"Laurent Martiny","orcid":"https://orcid.org/0000-0002-4667-2860","observed_orcids":["https://orcid.org/0000-0002-4667-2860"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Martiny","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015785052","display_name":"Laurent Debelle","orcid":"https://orcid.org/0000-0002-7416-3676","observed_orcids":["https://orcid.org/0000-0002-7416-3676"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Debelle","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067585382","display_name":"Laurent Duca","orcid":"https://orcid.org/0000-0002-6035-4906","observed_orcids":["https://orcid.org/0000-0002-6035-4906"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387155780","display_name":"Matrice Extracellulaire et Dynamique Cellulaire MEDyC","ror":"https://ror.org/017p6sq53","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laurent Duca","raw_affiliation_strings":["UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR CNRS/URCA 7369, SFR CAP Sant\u00e9, Universit\u00e9 de Reims Champagne Ardenne, Facult\u00e9 des Sciences, Reims, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067585382"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387155780","https://openalex.org/I96226040"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.7474,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.617737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":null,"first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.45210000872612,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.45210000872612,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.1354999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.12929999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastin-derived-peptides","display_name":"elastin peptides","score":0.906000018119812},{"id":"https://openalex.org/keywords/elastin-binding-protein","display_name":"elastin binding protein","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neu1","display_name":"NEU1","score":0.7979999780654907},{"id":"https://openalex.org/keywords/neuraminidase","display_name":"neuraminidase","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cathepsin-a","display_name":"cathepsin A","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cancer-associated-thrombosis","display_name":"cancer-associated thrombosis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8259999752044678},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.824999988079071},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.6150000095367432},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.7729420065879822},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5849946737289429},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5259561538696289},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5090414881706238},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4709143340587616},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4595438838005066},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.439706951379776},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43361207842826843},{"id":"https://openalex.org/C2778122751","wikidata":"https://www.wikidata.org/wiki/Q5446488","display_name":"Fibulin","level":3,"score":0.42574116587638855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4192415475845337},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.41153624653816223},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4097869396209717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37936267256736755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3345491290092468},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21785756945610046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18887314200401306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18215399980545044}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fphar.2016.00032","doi":"https://doi.org/10.3389/fphar.2016.00032","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2016.00032","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00032/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3758594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4777733","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26973522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26973522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4777733","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4777733/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-02331275v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.univ-reims.fr/hal-02331275","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1663-9812","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02347521v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02347521","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, 2016, 7, ⟨10.3389/fphar.2016.00032⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:194bff1f726d461090cba1aa039dc645","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/194bff1f726d461090cba1aa039dc645","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 7 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2016.00032","doi":"https://doi.org/10.3389/fphar.2016.00032","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2016.00032","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00032/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322890","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche","ror":"https://ror.org/03sjk9a61"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320329579","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2302115779.pdf","grobid_xml":"https://content.openalex.org/works/W2302115779.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W2223292","https://openalex.org/W127344325","https://openalex.org/W147118240","https://openalex.org/W173093991","https://openalex.org/W311788996","https://openalex.org/W1506559305","https://openalex.org/W1507468262","https://openalex.org/W1559688826","https://openalex.org/W1565388169","https://openalex.org/W1567852653","https://openalex.org/W1575055097","https://openalex.org/W1584346353","https://openalex.org/W1645383690","https://openalex.org/W1900545099","https://openalex.org/W1963816691","https://openalex.org/W1964496770","https://openalex.org/W1968114204","https://openalex.org/W1968384520","https://openalex.org/W1968505541","https://openalex.org/W1968519475","https://openalex.org/W1971235918","https://openalex.org/W1972038244","https://openalex.org/W1973868162","https://openalex.org/W1974268074","https://openalex.org/W1974305111","https://openalex.org/W1974680421","https://openalex.org/W1978532655","https://openalex.org/W1978536616","https://openalex.org/W1979151905","https://openalex.org/W1982471249","https://openalex.org/W1982683136","https://openalex.org/W1982843262","https://openalex.org/W1986287753","https://openalex.org/W1988782755","https://openalex.org/W1988784161","https://openalex.org/W1993829402","https://openalex.org/W1994465777","https://openalex.org/W1994861798","https://openalex.org/W1995790371","https://openalex.org/W1995935980","https://openalex.org/W1997471882","https://openalex.org/W1997543277","https://openalex.org/W1998220846","https://openalex.org/W1998535246","https://openalex.org/W2000856419","https://openalex.org/W2002890534","https://openalex.org/W2004875671","https://openalex.org/W2006563019","https://openalex.org/W2007125478","https://openalex.org/W2007441851","https://openalex.org/W2007853914","https://openalex.org/W2008591577","https://openalex.org/W2012167887","https://openalex.org/W2013214083","https://openalex.org/W2013848838","https://openalex.org/W2014594219","https://openalex.org/W2015075375","https://openalex.org/W2016491007","https://openalex.org/W2017121834","https://openalex.org/W2018253132","https://openalex.org/W2022782625","https://openalex.org/W2024555329","https://openalex.org/W2026240866","https://openalex.org/W2027227344","https://openalex.org/W2028468437","https://openalex.org/W2031097767","https://openalex.org/W2033580696","https://openalex.org/W2034863072","https://openalex.org/W2035243912","https://openalex.org/W2043919610","https://openalex.org/W2044734165","https://openalex.org/W2045070438","https://openalex.org/W2046007528","https://openalex.org/W2046356346","https://openalex.org/W2046819329","https://openalex.org/W2046873454","https://openalex.org/W2050198557","https://openalex.org/W2051016429","https://openalex.org/W2053142936","https://openalex.org/W2053649115","https://openalex.org/W2054446875","https://openalex.org/W2054487087","https://openalex.org/W2054733067","https://openalex.org/W2055996323","https://openalex.org/W2057733376","https://openalex.org/W2059069305","https://openalex.org/W2059196338","https://openalex.org/W2062314956","https://openalex.org/W2062637797","https://openalex.org/W2065166241","https://openalex.org/W2065328100","https://openalex.org/W2067914624","https://openalex.org/W2072570417","https://openalex.org/W2074918050","https://openalex.org/W2078224872","https://openalex.org/W2078410720","https://openalex.org/W2079238342","https://openalex.org/W2080769950","https://openalex.org/W2081958397","https://openalex.org/W2083252148","https://openalex.org/W2092473587","https://openalex.org/W2094546356","https://openalex.org/W2094708727","https://openalex.org/W2100249107","https://openalex.org/W2105216609","https://openalex.org/W2116717938","https://openalex.org/W2118799285","https://openalex.org/W2120854891","https://openalex.org/W2130796372","https://openalex.org/W2132286891","https://openalex.org/W2133837686","https://openalex.org/W2134652066","https://openalex.org/W2135729260","https://openalex.org/W2140820046","https://openalex.org/W2147089345","https://openalex.org/W2153388523","https://openalex.org/W2156203925","https://openalex.org/W2159830267","https://openalex.org/W2164692123","https://openalex.org/W2165673838","https://openalex.org/W2235733126","https://openalex.org/W2345327733","https://openalex.org/W2402954445","https://openalex.org/W2415829448","https://openalex.org/W2417374837","https://openalex.org/W2418200037","https://openalex.org/W2418616153","https://openalex.org/W2490019007","https://openalex.org/W2604189857","https://openalex.org/W4210961984","https://openalex.org/W4255227445","https://openalex.org/W6630020354"],"related_works":["https://openalex.org/W3080550020","https://openalex.org/W2031304251","https://openalex.org/W3180438429","https://openalex.org/W1975224878","https://openalex.org/W4211109295","https://openalex.org/W7006356399","https://openalex.org/W7147238308","https://openalex.org/W2019078583","https://openalex.org/W7023959527","https://openalex.org/W1565388169"],"abstract_inverted_index":{"Elastin,":[0],"one":[1],"of":[2,26,36,125],"the":[3,34,88,106,164,218],"longest-lived":[4],"proteins,":[5],"confers":[6],"elasticity":[7],"to":[8,33,49,76,105,115,130],"tissues":[9],"with":[10],"high":[11],"mechanical":[12],"constraints.":[13],"During":[14],"aging":[15],"or":[16],"pathophysiological":[17],"conditions":[18],"such":[19,236],"as":[20,152,237],"cancer":[21,162,177,201],"progression,":[22,163],"this":[23,191,205],"insoluble":[24],"polymer":[25],"tropoelastin":[27],"undergoes":[28],"an":[29,172],"important":[30,173],"degradation":[31],"leading":[32],"release":[35],"bioactive":[37],"elastin-derived":[38],"peptides":[39],"(EDPs),":[40],"named":[41,99],"elastokines.":[42],"EDP":[43],"exhibit":[44],"several":[45,71],"biological":[46],"functions":[47],"able":[48],"drive":[50],"tumor":[51,66],"development":[52,178,202],"by":[53],"regulating":[54],"cell":[55],"proliferation,":[56],"invasion,":[57],"survival,":[58],"angiogenesis,":[59],"and":[60,67,80,148,170,179,197,234,239],"matrix":[61],"metalloproteinase":[62],"expression":[63],"in":[64,161,185,200,231],"various":[65],"stromal":[68],"cells.":[69],"Although,":[70],"receptors":[72],"have":[73,127],"been":[74,128],"suggested":[75],"bind":[77],"elastokines":[78,126,198],"(\u03b1v\u03b23":[79],"\u03b1v\u03b25":[81],"integrins,":[82],"galectin-3),":[83],"their":[84,131,142],"main":[85],"receptor":[86,90,207],"remains":[87],"elastin":[89,100],"complex":[91],"(ERC).":[92],"This":[93],"heterotrimer":[94],"comprises":[95],"a":[96,116,180,210],"peripheral":[97],"subunit,":[98],"binding":[101,132],"protein":[102,118],"(EBP),":[103],"associated":[104],"protective":[107],"protein/cathepsin":[108],"A":[109],"(PPCA).":[110],"The":[111,122],"latter":[112],"is":[113,139],"bound":[114],"membrane-associated":[117],"called":[119],"Neuraminidase-1":[120],"(Neu-1).":[121],"pro-tumoral":[123,225],"effects":[124],"linked":[129],"onto":[133],"EBP.":[134],"Additionally,":[135],"Neu-1":[136,149],"sialidase":[137],"activity":[138,150],"essential":[140],"for":[141,176],"signal":[143],"transduction.":[144],"Consistently,":[145],"EDP-EBP":[146],"interaction":[147],"emerge":[151],"original":[153],"anti-tumoral":[154],"targets.":[155],"Interestingly,":[156],"besides":[157],"its":[158,224,228],"direct":[159],"involvement":[160,199],"ERC":[165,196],"also":[166,216,244],"regulates":[167],"diabetes":[168,238],"outcome":[169],"thrombosis,":[171],"risk":[174],"factor":[175],"vascular":[181],"process":[182],"highly":[183],"increased":[184],"patients":[186],"suffering":[187],"from":[188],"cancer.":[189],"In":[190],"review,":[192],"we":[193],"will":[194,215,242],"describe":[195],"suggesting":[203],"that":[204],"unique":[206],"would":[208],"be":[209,243],"promising":[211],"therapeutic":[212],"target.":[213],"We":[214],"discuss":[217],"pharmacological":[219],"concepts":[220],"aiming":[221],"at":[222],"blocking":[223],"activities.":[226],"Finally,":[227],"emerging":[229],"role":[230],"cancer-associated":[232],"complications":[233],"pathologies":[235],"thrombotic":[240],"events":[241],"considered.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}