{"id":"https://openalex.org/W2302017345","doi":null,"title":"Gentamicin dosage requirements: wide interpatient variations in 242 surgery patients with normal renal function.","display_name":"Gentamicin dosage requirements: wide interpatient variations in 242 surgery patients with normal renal function.","publication_year":1980,"publication_date":"1980-02-01","ids":{"openalex":"https://openalex.org/W2302017345","mag":"2302017345","pmid":"https://pubmed.ncbi.nlm.nih.gov/7355388"},"language":"en","primary_location":{"id":"pmid:7355388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7355388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008341891","display_name":"Darwin E. Zaske","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Zaske","raw_affiliation_strings":["From the Department of Surgery, University of Minnesota School of Medicine, St. Paul, Minn., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery, University of Minnesota School of Medicine, St. Paul, Minn., USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055398759","display_name":"Robert J. Cipolle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Cipolle","raw_affiliation_strings":["From the Department of Surgery, University of Minnesota School of Medicine, St. Paul, Minn., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery, University of Minnesota School of Medicine, St. Paul, Minn., USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110030349","display_name":"Richard J. Strate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Strate","raw_affiliation_strings":["From the Department of Surgery, University of Minnesota School of Medicine, St. Paul, Minn., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery, University of Minnesota School of Medicine, St. Paul, Minn., USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":7.5371,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.97566628,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"87","issue":"2","first_page":"164","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":1.0},{"id":"https://openalex.org/keywords/interpatient-variability","display_name":"interpatient variability","score":0.7580000162124634},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.37700000405311584},{"id":"https://openalex.org/keywords/serum-concentration-monitoring","display_name":"serum concentration monitoring","score":0.6949999928474426},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.7289999723434448},{"id":"https://openalex.org/keywords/normal-renal-function","display_name":"normal renal function","score":0.902999997138977},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.6959999799728394},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/peak-and-trough-levels","display_name":"peak and trough levels","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9242424964904785},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.8331328630447388},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7899223566055298},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7064033150672913},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.6242318153381348},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.6176344752311707},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.6160397529602051},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.596479058265686},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5128472447395325},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.5094214081764221},{"id":"https://openalex.org/C2910800852","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough Concentration","level":3,"score":0.49739697575569153},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4288121461868286},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4154115319252014},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32435911893844604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3138313889503479},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2921752333641052},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2729793190956116},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26903557777404785},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.07954147458076477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7355388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7355388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"mag:2302017345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7355388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W153318821","https://openalex.org/W1973227858","https://openalex.org/W1979689329","https://openalex.org/W2020892618","https://openalex.org/W2024355003","https://openalex.org/W2026680546","https://openalex.org/W2080151047","https://openalex.org/W2085823805","https://openalex.org/W2089016219","https://openalex.org/W2090750145","https://openalex.org/W2091007912","https://openalex.org/W2094761246","https://openalex.org/W2116240842","https://openalex.org/W2130136798","https://openalex.org/W2148260097","https://openalex.org/W2164799018","https://openalex.org/W2246400681","https://openalex.org/W2313470740","https://openalex.org/W2415124299","https://openalex.org/W4240693037"],"related_works":["https://openalex.org/W1559348342","https://openalex.org/W2018246383","https://openalex.org/W2013536237","https://openalex.org/W2165282412","https://openalex.org/W73743086","https://openalex.org/W2262421838","https://openalex.org/W2094761246","https://openalex.org/W1480929631","https://openalex.org/W2440011130","https://openalex.org/W2071669607"],"abstract_inverted_index":{"Wide":[0],"interpatient":[1,60,182],"variations":[2,61],"were":[3,101,147],"demonstrated":[4,111],"in":[5,62,73,88,104],"gentamicin":[6],"elimination":[7],"rate":[8],"and":[9,80,97,136,145,168],"dosage":[10,85,109,171,186],"requirements":[11],"for":[12],"242":[13],"surgery":[14,131],"patients":[15,132,153],"with":[16,66,150],"normal":[17],"renal":[18],"function.":[19],"These":[20,58,158],"patients'":[21],"half-lives":[22],"ranged":[23,42],"from":[24,43,114],"0.4":[25],"to":[26,31,36,45,55,69,116,120,125,164,173],"13.4":[27],"hours":[28],"as":[29,48],"compared":[30,49],"previous":[32],"reports":[33],"of":[34,50,53,129,143,179],"2.5":[35],"4":[37],"hours.":[38],"The":[39,141],"distribution":[40],"volumes":[41],"0.06":[44],"0.63":[46],"liter/kg,":[47],"reported":[51],"values":[52],"0.20":[54],"0.25":[56],"liter/kg.":[57],"wide":[59,181],"kinetic":[63],"parameters,":[64],"combined":[65],"the":[67,89,121,162,180],"need":[68,163],"obtain":[70],"narrow":[71],"ranges":[72],"serum":[74,78,99,166,195],"concentrations,":[75],"necessitated":[76],"measuring":[77,194],"concentrations":[79,167],"individually":[81],"calculating":[82],"each":[83],"patient's":[84],"regimen":[86,123],"early":[87],"treatment":[90],"course.":[91],"Using":[92],"this":[93],"approach,":[94],"optimal":[95],"peak":[96],"trough":[98],"levels":[100],"consistently":[102],"produced":[103],"these":[105,130,184],"patients.":[106],"Their":[107],"required":[108,133,138],"regimens":[110,187],"considerable":[112],"variability--ranging":[113],"0.7":[115],"12.4":[117],"mg/kg/day.":[118],"Compared":[119],"recommended":[122],"(3":[124],"5":[126],"mg/kg/day),":[127],"47%":[128],"higher":[134],"dosages,":[135],"14%":[137],"lower":[139],"dosages.":[140],"incidence":[142],"ototoxicity":[144],"nephrotoxicity":[146],"extremely":[148],"low,":[149],"only":[151],"three":[152],"possibly":[154],"having":[155],"gentamicin-associated":[156],"nephrotoxicity.":[157],"results":[159],"further":[160],"emphasize":[161],"measure":[165],"make":[169],"necessary":[170],"adjustments":[172],"ensure":[174],"therapeutic":[175],"levels.":[176],"However,":[177],"because":[178],"variation,":[183],"increased":[185],"are":[188],"not":[189],"routinely":[190],"suggested":[191],"without":[192],"previously":[193],"concentrations.":[196]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
