{"id":"https://openalex.org/W2302011199","doi":"https://doi.org/10.1159/000438651","title":"TGF-\u03b2 Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1\u03b1-Induced Epithelial Mesenchymal Transition","display_name":"TGF-\u03b2 Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1\u03b1-Induced Epithelial Mesenchymal Transition","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2302011199","doi":"https://doi.org/10.1159/000438651","mag":"2302011199","pmid":"https://pubmed.ncbi.nlm.nih.gov/26845171"},"language":"en","primary_location":{"id":"doi:10.1159/000438651","doi":"https://doi.org/10.1159/000438651","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000438651","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1159/000438651","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112551396","display_name":"Min\u2010Jin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Jin Kim","raw_affiliation_strings":["College of Pharmacy, Ewha Womans University, Seoul, Korea","College of Pharmacy, Ewha Womans University, Seoul,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul,","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091322744","display_name":"Sang-a Park","orcid":"https://orcid.org/0000-0001-7385-489X","observed_orcids":["https://orcid.org/0000-0001-7385-489X"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-A Park","raw_affiliation_strings":["College of Pharmacy, Ewha Womans University, Seoul,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul,","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008428302","display_name":"Chun Hwa Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139534","display_name":"Hyundai Pharm (South Korea)","ror":"https://ror.org/0340bsg82","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210139534"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chun Hwa Kim","raw_affiliation_strings":["New Drug Discovery Lab, Hyundai Pharm, Yongin,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Discovery Lab, Hyundai Pharm, Yongin,","institution_ids":["https://openalex.org/I4210139534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108048478","display_name":"So-Yeon Park","orcid":"https://orcid.org/0000-0001-8241-5135","observed_orcids":["https://orcid.org/0000-0001-8241-5135"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So-Yeon Park","raw_affiliation_strings":["College of Pharmacy, Ewha Womans University, Seoul,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul,","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jung-Shin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Shin Kim","raw_affiliation_strings":["College of Pharmacy, Ewha Womans University, Seoul,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul,","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143382","display_name":"Dae\u2010Kee Kim","orcid":"https://orcid.org/0000-0002-1018-4486","observed_orcids":["https://orcid.org/0000-0002-1018-4486"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dae-Kee Kim","raw_affiliation_strings":["College of Pharmacy, Ewha Womans University, Seoul,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul,","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071676695","display_name":"Jeong\u2010Seok Nam","orcid":"https://orcid.org/0000-0001-9753-6095","observed_orcids":["https://orcid.org/0000-0001-9753-6095"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong-Seok Nam","raw_affiliation_strings":["Laboratory of Tumor Suppressor, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Suppressor, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000413124","display_name":"Yhun Yhong Sheen","orcid":"https://orcid.org/0000-0002-4928-1611","observed_orcids":["https://orcid.org/0000-0002-4928-1611"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yhun Yhong Sheen","raw_affiliation_strings":["College of Pharmacy, Ewha Womans University, Seoul,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ewha Womans University, Seoul,","institution_ids":["https://openalex.org/I138925566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":5.7775,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.96396755,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"38","issue":"2","first_page":"571","last_page":"588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholestatic-liver-fibrosis","display_name":"cholestatic liver fibrosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.878000020980835},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7263200283050537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5771032571792603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48582029342651367},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.46466076374053955},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44591736793518066},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.43975579738616943},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42120909690856934},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.41454723477363586},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35630905628204346},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.333096981048584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31412431597709656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30945783853530884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.266391783952713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14681312441825867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08677566051483154}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000438651","doi":"https://doi.org/10.1159/000438651","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000438651","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:26845171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26845171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aa1967a19fd447b5a3ed5d4bab9e9129","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aa1967a19fd447b5a3ed5d4bab9e9129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Physiology and Biochemistry, Vol 38, Iss 2, Pp 571-588 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000438651","doi":"https://doi.org/10.1159/000438651","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000438651","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W201653061","https://openalex.org/W1488267025","https://openalex.org/W1533448811","https://openalex.org/W1760215417","https://openalex.org/W1906235443","https://openalex.org/W1963780536","https://openalex.org/W1963965802","https://openalex.org/W1966475752","https://openalex.org/W1968068668","https://openalex.org/W1971730330","https://openalex.org/W1974087825","https://openalex.org/W1975022233","https://openalex.org/W1976809932","https://openalex.org/W1979087898","https://openalex.org/W1981536082","https://openalex.org/W1990404138","https://openalex.org/W1996438825","https://openalex.org/W2000607506","https://openalex.org/W2007237158","https://openalex.org/W2010139831","https://openalex.org/W2015039463","https://openalex.org/W2017463647","https://openalex.org/W2018230845","https://openalex.org/W2025029681","https://openalex.org/W2039775393","https://openalex.org/W2042198997","https://openalex.org/W2042537814","https://openalex.org/W2044247477","https://openalex.org/W2051611091","https://openalex.org/W2053470746","https://openalex.org/W2056937212","https://openalex.org/W2058182256","https://openalex.org/W2059872520","https://openalex.org/W2060583228","https://openalex.org/W2063821082","https://openalex.org/W2071335476","https://openalex.org/W2071489477","https://openalex.org/W2075584603","https://openalex.org/W2077688090","https://openalex.org/W2080325240","https://openalex.org/W2083437811","https://openalex.org/W2085609942","https://openalex.org/W2090786698","https://openalex.org/W2095025412","https://openalex.org/W2095769813","https://openalex.org/W2095894499","https://openalex.org/W2097059462","https://openalex.org/W2100438537","https://openalex.org/W2111071424","https://openalex.org/W2116596367","https://openalex.org/W2122808924","https://openalex.org/W2132892999","https://openalex.org/W2142641037","https://openalex.org/W2145002455","https://openalex.org/W2149162265","https://openalex.org/W2149391365","https://openalex.org/W2156668607","https://openalex.org/W2159033534","https://openalex.org/W2174542233","https://openalex.org/W2255407769","https://openalex.org/W2271008887","https://openalex.org/W2604337567"],"related_works":["https://openalex.org/W2156668607","https://openalex.org/W4413400612","https://openalex.org/W2039775393","https://openalex.org/W4411557144","https://openalex.org/W4410422516","https://openalex.org/W1971394397","https://openalex.org/W2295919621","https://openalex.org/W2096314064","https://openalex.org/W3036208866","https://openalex.org/W7009633844"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Hypoxia":[1],"is":[2],"an":[3],"environmental":[4],"factor":[5],"that":[6,160],"aggravates":[7],"liver":[8,57,78,96,168],"fibrosis.":[9,33,58,79],"HIF1\u03b1":[10],"activates":[11],"hepatic":[12],"stellate":[13],"cells":[14,86,153],"(HSCs)":[15],"and":[16,23,98,115,129,135,146],"increases":[17],"transforming":[18],"growth":[19],"factor-\u03b2":[20],"(TGF-\u03b2)":[21],"signaling":[22,54,76],"the":[24,30,36,71],"epithelial":[25],"mesenchymal":[26],"transition":[27],"(EMT),":[28],"accelerating":[29],"progression":[31],"of":[32,40,44,73,93,133,148],"We":[34,60],"evaluated":[35],"anti-fibrotic":[37,91],"therapeutic":[38],"potential":[39,163],"a":[41,62,165],"small-molecule":[42],"inhibitor":[43],"TGF-\u03b2":[45,53,75,174],"type":[46],"I":[47],"receptor":[48],"kinase,":[49],"EW-7197,":[50],"on":[51],"HIF1\u03b1-derived":[52,74,143],"in":[55,77,84,95,137,151,154],"cholestatic":[56],"METHODS:":[59],"used":[61],"bile":[63],"duct":[64],"ligation":[65],"(BDL)-operated":[66],"rat":[67,122],"model":[68],"to":[69],"characterize":[70],"role":[72],"Cellular":[80],"assays":[81],"were":[82,100],"performed":[83],"LX-2":[85,152],"(human":[87],"immortalized":[88],"HSCs).":[89],"The":[90],"effects":[92],"EW-7197":[94,126,141,161],"tissues":[97],"HSCs":[99,134],"investigated":[101],"via":[102],"biochemical":[103],"assays,":[104,112],"immunohistochemistry":[105],"(IHC),":[106],"immunofluorescence":[107],"(IF),":[108],"chromatin":[109],"immunoprecipitation":[110],"(ChIP)":[111],"real-time":[113],"PCR,":[114],"western":[116],"blotting.":[117],"RESULTS:":[118],"In":[119,139],"our":[120],"BDL":[121],"model,":[123],"orally":[124],"administered":[125],"inhibited":[127,142],"fibrosis":[128,169],"attenuated":[130],"HIF1\u03b1-induced":[131,173],"activation":[132,145],"EMT":[136,149],"vivo.":[138],"addition,":[140],"HSC":[144],"expression":[147],"markers":[150],"vitro.":[155],"CONCLUSION:":[156],"This":[157],"study":[158],"suggests":[159],"exhibits":[162],"as":[164],"treatment":[166],"for":[167],"because":[170],"it":[171],"inhibits":[172],"signaling.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
