{"id":"https://openalex.org/W2301503533","doi":null,"title":"The vitamin D3 analog calcipotriol suppresses the number and antigen-presenting function of Langerhans cells in normal human skin.","display_name":"The vitamin D3 analog calcipotriol suppresses the number and antigen-presenting function of Langerhans cells in normal human skin.","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2301503533","mag":"2301503533","pmid":"https://pubmed.ncbi.nlm.nih.gov/9627697"},"language":"en","primary_location":{"id":"pmid:9627697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9627697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of investigative dermatology. Symposium proceedings","raw_type":"Journal Article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112010262","display_name":"Thomas N. Dam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T N Dam","raw_affiliation_strings":["Department of Dermatology, University of Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081677181","display_name":"Burkhard M\u00f6ller","orcid":"https://orcid.org/0000-0001-8769-6167","observed_orcids":["https://orcid.org/0000-0001-8769-6167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B M\u00f8ller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044608668","display_name":"Johnny Hindkj\u00e6r","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hindkjaer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068079740","display_name":"Knud Kragballe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kragballe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":26.0,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.99186992,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"72","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.05990000069141388,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcipotriol","display_name":"calcipotriol","score":1.0},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9399999976158142},{"id":"https://openalex.org/keywords/vitamin-d3-analogues","display_name":"vitamin D3 analogs","score":0.8080000281333923},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7409999966621399},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/normal-human-skin","display_name":"normal human skin","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cd1a","display_name":"CD1a","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.7279999852180481},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.5889999866485596},{"id":"https://openalex.org/keywords/mometasone-furoate","display_name":"mometasone furoate","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2776009542","wikidata":"https://www.wikidata.org/wiki/Q155683","display_name":"Calcipotriol","level":3,"score":0.9707047343254089},{"id":"https://openalex.org/C2778379841","wikidata":"https://www.wikidata.org/wiki/Q1623344","display_name":"Langerhans cell","level":3,"score":0.6331285238265991},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.592708945274353},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5064657926559448},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4926021695137024},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4812619388103485},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4344043731689453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43335187435150146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4200688600540161},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.419938325881958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40573108196258545},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.386577308177948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31393715739250183},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018167","descriptor_name":"Receptors, Calcitriol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9627697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9627697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of investigative dermatology. Symposium proceedings","raw_type":"Journal Article"},{"id":"mag:2301503533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9627697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134833914","https://openalex.org/W2096387403","https://openalex.org/W2012326513","https://openalex.org/W1678817753","https://openalex.org/W1964657870","https://openalex.org/W2039641336","https://openalex.org/W2063619640","https://openalex.org/W2030814901","https://openalex.org/W2014520634","https://openalex.org/W2405778729"],"abstract_inverted_index":{"Local":[0],"activation":[1],"of":[2,37,48,62,81,91,109,120,127,137,191,220],"T":[3],"lymphocytes":[4],"appears":[5],"to":[6,29,42,58,71,94,164],"play":[7],"an":[8],"important":[9],"role":[10],"in":[11,33,45,53,102,106,117,180,197,230],"psoriasis":[12],"and":[13,20,57,65,116,156],"autoimmune":[14],"skin":[15,56,97],"disease.":[16],"1":[17],"alpha,25-dihydroxyvitamin":[18],"D3":[19,23,64,155,223],"the":[21,38,44,60,107,118,138,170,181,198,217,221,231],"vitamin":[22,171,222],"analog":[24],"calcipotriol":[25,49,66,92,128,157],"have":[26],"been":[27],"shown":[28],"inhibit":[30],"immune":[31],"induction":[32],"vitro.":[34],"The":[35,124],"purpose":[36],"present":[39],"study":[40],"was":[41,87,132,174],"investigate":[43],"vivo":[46],"effect":[47,61,126],"on":[50,67,129,224],"Langerhans":[51,69,130,143,183,192,225],"cells":[52,70,111,131,193,226],"normal":[54,95,151],"human":[55,96,152,199],"determine":[59],"1,25-dihydroxyvitamin":[63,154],"isolated":[68,149,182],"induce":[72,228],"autologous":[73],"T-cell":[74,167],"proliferation.":[75,168],"Using":[76],"confocal":[77],"laser":[78],"scanning":[79],"microscopy":[80],"epidermal":[82],"suction":[83],"blister":[84],"roofs,":[85],"it":[86],"found":[88],"that":[89,136,216],"application":[90],"cream":[93],"for":[98],"4":[99],"d":[100],"resulted":[101],"a":[103,113],"dose-dependent":[104],"decrease":[105],"number":[108,119],"CD1a+":[110],"with":[112,207,209],"dendritic":[114],"morphology":[115],"dendrites":[121],"per":[122],"cell.":[123],"suppressive":[125],"as":[133,135],"strong":[134],"potent":[139],"corticosteroid":[140],"mometasonfuroate.":[141],"In":[142],"cell-enriched":[144],"cell":[145],"suspensions":[146],"(60-97%":[147],"pure)":[148],"from":[150],"skin,":[153],"(10(-8)-10(-7)":[158],"M)":[159],"significantly":[160],"suppressed":[161],"their":[162],"ability":[163],"stimulate":[165],"antigen-dependent":[166],"Furthermore,":[169],"D":[172],"receptor":[173],"detected":[175],"by":[176],"Western":[177],"blot":[178],"analysis":[179],"cells.":[184],"Neither":[185],"immunohistochemical":[186],"studies":[187],"nor":[188],"flow":[189],"cytometry":[190],"showed":[194],"any":[195],"change":[196],"leukocyte":[200],"antigen-DR":[201],"expression":[202],"after":[203],"48":[204],"h":[205],"culture":[206],"antigen":[208],"or":[210],"without":[211],"calcipotriol.":[212],"It":[213],"is":[214],"proposed":[215],"inhibitory":[218],"effects":[219],"may":[227],"immunosuppression":[229],"skin.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}