{"id":"https://openalex.org/W2301112982","doi":null,"title":"In Silico Metabolic Network Reconstruction of Scheffersomyces Stipitis","display_name":"In Silico Metabolic Network Reconstruction of Scheffersomyces Stipitis","publication_year":2012,"publication_date":"2012-07-26","ids":{"openalex":"https://openalex.org/W2301112982","mag":"2301112982"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/32597","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32597","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5fe64f28-b68e-4ebc-a7f4-397e2b0699c7/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/5fe64f28-b68e-4ebc-a7f4-397e2b0699c7/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061435077","display_name":"Peter Yan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter Yan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061435077"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scheffersomyces-stipitis","display_name":"Scheffersomyces stipitis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/genome-scale-metabolic-models","display_name":"genome-scale metabolic models","score":0.9449999928474426},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"flux balance analysis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ethanol-yield","display_name":"ethanol yield","score":0.7609999775886536},{"id":"https://openalex.org/keywords/carbon-substrates","display_name":"carbon substrates","score":0.7680000066757202},{"id":"https://openalex.org/keywords/central-carbon-metabolism","display_name":"central carbon metabolism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pathway-genome-databases","display_name":"pathway/genome databases","score":0.9470000267028809},{"id":"https://openalex.org/keywords/genome-annotation","display_name":"genome annotation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.6169999837875366},{"id":"https://openalex.org/keywords/yeast-metabolism","display_name":"yeast metabolism","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.8424302339553833},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6410324573516846},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6288971900939941},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6092013120651245},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.463466078042984},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.44420355558395386},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4343111217021942},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4156637489795685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36321380734443665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.343132346868515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2614777088165283}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/32597","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32597","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5fe64f28-b68e-4ebc-a7f4-397e2b0699c7/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/32597","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/32597","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2301112982","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/32597/11/Li_Peter_Y_201206_MASC_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/32597","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32597","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5fe64f28-b68e-4ebc-a7f4-397e2b0699c7/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307011","display_name":"McLean Foundation","ror":"https://ror.org/041475e22"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2301112982.pdf","grobid_xml":"https://content.openalex.org/works/W2301112982.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W4360673","https://openalex.org/W59031459","https://openalex.org/W1511776621","https://openalex.org/W1525974625","https://openalex.org/W1564324880","https://openalex.org/W1597762351","https://openalex.org/W1606143283","https://openalex.org/W1804208390","https://openalex.org/W1847715912","https://openalex.org/W1855933245","https://openalex.org/W1967687694","https://openalex.org/W1968499092","https://openalex.org/W1970871100","https://openalex.org/W1978104256","https://openalex.org/W1980393312","https://openalex.org/W1981865837","https://openalex.org/W1986154637","https://openalex.org/W1991670075","https://openalex.org/W2006053013","https://openalex.org/W2009943545","https://openalex.org/W2019026460","https://openalex.org/W2025663053","https://openalex.org/W2030776070","https://openalex.org/W2031681107","https://openalex.org/W2047632644","https://openalex.org/W2048031766","https://openalex.org/W2048214825","https://openalex.org/W2052272099","https://openalex.org/W2053837262","https://openalex.org/W2072581977","https://openalex.org/W2075814472","https://openalex.org/W2076262841","https://openalex.org/W2082172840","https://openalex.org/W2085993965","https://openalex.org/W2086209215","https://openalex.org/W2096659908","https://openalex.org/W2098824895","https://openalex.org/W2101127697","https://openalex.org/W2110443726","https://openalex.org/W2130364940","https://openalex.org/W2146209621","https://openalex.org/W2147472054","https://openalex.org/W2147580636","https://openalex.org/W2151015883","https://openalex.org/W2151785115","https://openalex.org/W2156381277","https://openalex.org/W2158427229","https://openalex.org/W2158784643","https://openalex.org/W2160530532","https://openalex.org/W2162373261","https://openalex.org/W2168846334","https://openalex.org/W2317778141"],"related_works":["https://openalex.org/W2440036468","https://openalex.org/W2092513081","https://openalex.org/W3082638094","https://openalex.org/W2700222433","https://openalex.org/W1990378348","https://openalex.org/W2075919068","https://openalex.org/W2079531107","https://openalex.org/W7127299994","https://openalex.org/W2561350903","https://openalex.org/W2112165937"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"a":[3,57,111,121],"genome-scale":[4],"metabolic":[5,115],"model":[6,24,51],"was":[7,25,53,69,126],"constructed":[8,70],"using":[9,71],"published":[10],"genomic":[11],"and":[12,38,74,85,120],"biochemical":[13],"data.":[14],"By":[15],"employing":[16],"the":[17,23,50,54,63,75,92,100,108],"flux":[18],"balance":[19],"analysis":[20],"(FBA)":[21],"framework,":[22],"able":[26],"to":[27],"accurately":[28],"predict":[29],"ethanol":[30],"yields":[31],"on":[32],"various":[33,45],"carbon":[34],"substrates,":[35],"secretion":[36],"profiles,":[37],"key":[39],"characteristics":[40],"of":[41,49,56,62,94,102],"central":[42],"metabolism":[43],"under":[44],"growth":[46],"conditions.\\nA":[47],"by-product":[48],"development":[52],"construction":[55],"pathway":[58],"genome":[59],"data-base":[60],"(PGDB)":[61],"yeast,":[64],"named":[65],"PichCyc.":[66],"The":[67],"PGDB":[68],"Pathway":[72,88,103],"Tools":[73,89],"database":[76,125],"contains":[77],"5,841":[78],"genes,":[79],"1,457":[80],"reactions,":[81,84],"994":[82],"gene-associated":[83],"1,475":[86],"metabolites.":[87],"also":[90],"facilitated":[91],"annotation":[93],"an":[95],"additional":[96],"155":[97],"genes":[98],"through":[99],"use":[101],"Hole":[104],"Filler.":[105],"Together":[106],"with":[107],"constraint-based":[109],"model,":[110],"platform":[112],"for":[113],"model-guided":[114],"engineering,":[116],"high-throughput":[117],"data":[118],"contextualization,":[119],"public-access":[122],"online":[123],"genomic/biochemical":[124],"created.":[127]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}