{"id":"https://openalex.org/W2301038697","doi":"https://doi.org/10.1387/ijdb.7779682","title":"Expression of mesoderm markers in Xenopus laevis Keller explants","display_name":"Expression of mesoderm markers in Xenopus laevis Keller explants","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2301038697","doi":"https://doi.org/10.1387/ijdb.7779682","mag":"2301038697","pmid":"https://pubmed.ncbi.nlm.nih.gov/7779682"},"language":"en","primary_location":{"id":"doi:10.1387/ijdb.7779682","doi":"https://doi.org/10.1387/ijdb.7779682","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.7779682","pdf_url":"https://ijdb.ehu.eus/article/pdf/7779682","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ijdb.ehu.eus/article/pdf/7779682","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010040572","display_name":"Jean\u2010Pierre Saint\u2010Jeannet","orcid":"https://orcid.org/0000-0003-3259-2103","observed_orcids":["https://orcid.org/0000-0003-3259-2103"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J P Saint-Jeannet","raw_affiliation_strings":["Laboratory of Molecular Genetics , National Institute of Child Health and Human Development , Bethesda , Maryland , USA","Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics , National Institute of Child Health and Human Development , Bethesda , Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040446201","display_name":"A. A. Karavanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A A Karavanov","raw_affiliation_strings":["Laboratory of Molecular Genetics , National Institute of Child Health and Human Development , Bethesda , Maryland , USA","National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics , National Institute of Child Health and Human Development , Bethesda , Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I B Dawid","raw_affiliation_strings":["National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1265,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.41876346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"38","issue":"4","first_page":"605","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/xbra","display_name":"Xbra","score":0.7409999966621399},{"id":"https://openalex.org/keywords/convergence-and-extension","display_name":"convergence and extension","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neural-induction","display_name":"neural induction","score":0.5410000085830688},{"id":"https://openalex.org/keywords/mesoderm-patterning","display_name":"mesoderm patterning","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.9459693431854248},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8851301670074463},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.8523339629173279},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.6371339559555054},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.6290640830993652},{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.5795783996582031},{"id":"https://openalex.org/C66332042","wikidata":"https://www.wikidata.org/wiki/Q5425488","display_name":"FGF and mesoderm formation","level":5,"score":0.5386566519737244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5212922096252441},{"id":"https://openalex.org/C162407555","wikidata":"https://www.wikidata.org/wiki/Q6495669","display_name":"Lateral plate mesoderm","level":5,"score":0.4761900007724762},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4264218807220459},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3341004252433777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32116323709487915},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.31954652070999146},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.16614162921905518},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11452421545982361},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11238956451416016}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004475","descriptor_name":"Ectoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005775","descriptor_name":"Gastrula","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1387/ijdb.7779682","doi":"https://doi.org/10.1387/ijdb.7779682","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.7779682","pdf_url":"https://ijdb.ehu.eus/article/pdf/7779682","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},{"id":"pmid:7779682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7779682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of developmental biology","raw_type":"Journal Article"},{"id":"mag:2301038697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7779682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1387/ijdb.7779682","doi":"https://doi.org/10.1387/ijdb.7779682","is_oa":true,"landing_page_url":"https://doi.org/10.1387/ijdb.7779682","pdf_url":"https://ijdb.ehu.eus/article/pdf/7779682","source":{"id":"https://openalex.org/S47908780","display_name":"The International Journal of Developmental Biology","issn_l":"0214-6282","issn":["0214-6282","1696-3547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321029","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/P4310321029"],"host_organization_lineage_names":["University of the Basque Country"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.6100000143051147,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2301038697.pdf","grobid_xml":"https://content.openalex.org/works/W2301038697.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W2010041789","https://openalex.org/W2087835271","https://openalex.org/W2091223115","https://openalex.org/W2094741224","https://openalex.org/W2103168913","https://openalex.org/W2121358530","https://openalex.org/W2136633961","https://openalex.org/W2184976335","https://openalex.org/W2287093169"],"related_works":["https://openalex.org/W2008179424","https://openalex.org/W2088409058","https://openalex.org/W7099419329","https://openalex.org/W2123073901","https://openalex.org/W2112380907","https://openalex.org/W2052848998","https://openalex.org/W2103734027","https://openalex.org/W20264254","https://openalex.org/W2149051763","https://openalex.org/W1977496124"],"abstract_inverted_index":{"In":[0],"an":[1],"attempt":[2],"to":[3,99],"document":[4],"at":[5,74],"the":[6,9,21,49,54,64,71,79,88,101],"molecular":[7,28],"level":[8],"behavior":[10],"of":[11,24,26,30,53,63,104],"mesodermal":[12,43,66],"cells":[13,67],"in":[14,48,90,107],"Keller":[15],"explant":[16],"preparation,":[17],"we":[18],"have":[19],"analyzed":[20],"time":[22,76],"course":[23],"expression":[25,103],"four":[27],"markers":[29,44],"mesoderm":[31,55,82],"gsc,":[32],"Xbra,":[33],"Xnot":[34],"and":[35,61],"XLIM-1.":[36],"Our":[37],"findings":[38],"demonstrate":[39],"that,":[40],"(i)":[41],"all":[42],"tested":[45],"were":[46,96],"expressed":[47],"explants,":[50,65],"but":[51],"patterning":[52],"appeared":[56],"incomplete;":[57],"(ii)":[58],"during":[59],"convergence":[60],"extension":[62],"did":[68],"not":[69,97],"invade":[70],"ectodermal":[72],"tissue":[73],"any":[75],"tested,":[77],"supporting":[78],"view":[80],"that":[81],"establishes":[83],"exclusively":[84],"planar":[85,94],"contacts":[86,95],"with":[87],"ectoderm":[89],"this":[91],"preparation;":[92],"(iii)":[93],"sufficient":[98],"promote":[100],"neural":[102],"XLIM-1":[105],"protein":[106],"these":[108],"explants.":[109]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}