{"id":"https://openalex.org/W23010048","doi":null,"title":"Synergistic action of doxorubicin and sulindac in human cervix carcinoma cells - studies on possible mechanisms.","display_name":"Synergistic action of doxorubicin and sulindac in human cervix carcinoma cells - studies on possible mechanisms.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W23010048","mag":"23010048","pmid":"https://pubmed.ncbi.nlm.nih.gov/20037485"},"language":"en","primary_location":{"id":"pmid:20037485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20037485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029978947","display_name":"Beata Gruber","orcid":"https://orcid.org/0000-0003-2819-8576","observed_orcids":["https://orcid.org/0000-0003-2819-8576"]},"institutions":[{"id":"https://openalex.org/I4210166577","display_name":"Narodowy Instytut Lek\u00f3w","ror":"https://ror.org/05m2pwn60","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210166577"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Beata Maria Gruber","raw_affiliation_strings":["Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, Warsaw, Poland. b-gruber@il.waw.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, Warsaw, Poland. b-gruber@il.waw.pl","institution_ids":["https://openalex.org/I4210166577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038652134","display_name":"Irena Bubko","orcid":"https://orcid.org/0000-0001-9358-5498","observed_orcids":["https://orcid.org/0000-0001-9358-5498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irena Bubko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087672431","display_name":"Jolanta Krzyszto\u0144-Russjan","orcid":"https://orcid.org/0000-0001-7200-6178","observed_orcids":["https://orcid.org/0000-0001-7200-6178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanta Krzyszton-Russjan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000343896","display_name":"El\u017cbieta Anuszewska","orcid":"https://orcid.org/0000-0001-6740-4905","observed_orcids":["https://orcid.org/0000-0001-6740-4905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elzbieta Lidia Anuszewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3127,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.77513461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"BR45","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.36079999804496765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/sulindac","display_name":"sulindac","score":1.0},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8529999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.699999988079071},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7572939395904541},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7221547961235046},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6839720010757446},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.606898307800293},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5855263471603394},{"id":"https://openalex.org/C2776241388","wikidata":"https://www.wikidata.org/wiki/Q963093","display_name":"Sulindac","level":3,"score":0.5154021978378296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.513170063495636},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.49478715658187866},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4687362313270569},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.4544749855995178},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4436795115470886},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.38962772488594055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32707738876342773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17546451091766357},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14278149604797363},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20037485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20037485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},{"id":"mag:23010048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20037485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W2029749273","https://openalex.org/W2123624166","https://openalex.org/W2013706088","https://openalex.org/W262582492","https://openalex.org/W2050480486","https://openalex.org/W1977367854","https://openalex.org/W2017062022","https://openalex.org/W2071076789","https://openalex.org/W2017866598","https://openalex.org/W1564309939","https://openalex.org/W1980566972","https://openalex.org/W2157638962","https://openalex.org/W2065199512","https://openalex.org/W2013687747","https://openalex.org/W2019631980","https://openalex.org/W2084368884","https://openalex.org/W2063137363","https://openalex.org/W2144417922","https://openalex.org/W2066990963","https://openalex.org/W1993760429","https://openalex.org/W2072229818","https://openalex.org/W2057958245","https://openalex.org/W2088804850","https://openalex.org/W2130225212","https://openalex.org/W1972227250","https://openalex.org/W2092551112","https://openalex.org/W1982610073","https://openalex.org/W1972237096","https://openalex.org/W2144217084","https://openalex.org/W2039647080","https://openalex.org/W2002516695","https://openalex.org/W2133210720","https://openalex.org/W24101640","https://openalex.org/W2062379406","https://openalex.org/W2084582333","https://openalex.org/W2002948180","https://openalex.org/W1976371089","https://openalex.org/W2018129867","https://openalex.org/W2095190165","https://openalex.org/W2068524399"],"related_works":["https://openalex.org/W2051637937","https://openalex.org/W2378714657","https://openalex.org/W2133610610","https://openalex.org/W2152988065","https://openalex.org/W2165488163","https://openalex.org/W2562170297","https://openalex.org/W2014308148","https://openalex.org/W3032453636","https://openalex.org/W2314731261","https://openalex.org/W2371516798"],"abstract_inverted_index":{"BACKGROUND:":[0],"Epidemiologic":[1],"and":[2,38,65,95,116,130,174,185,215],"experimental":[3],"studies":[4],"have":[5],"shown":[6,109,166],"that":[7,110,191],"cyclooxygenase-2":[8],"(COX-2)":[9],"inhibitors":[10,28],"as":[11],"non-steroidal":[12],"anti-inflammatory":[13],"drugs":[14,74],"(NSAIDs)":[15],"are":[16,29,251],"effective":[17,121],"chemopreventive":[18],"agents.":[19],"The":[20,42,160,206],"mechanisms":[21,52,243],"underlying":[22],"the":[23,45,51,73,156,228,242],"antitumor":[24],"activity":[25,37,71],"of":[26,34,40,44,53,72,93,123,149,194,204,213,223,225,244,246],"COX-2":[27,35],"thought":[30],"to":[31,49,140,211,239],"involve":[32],"inhibition":[33],"enzyme":[36],"induction":[39],"apoptosis.":[41],"aim":[43],"current":[46],"work":[47],"was":[48,75,81,89,97,108,158],"study":[50],"synergistic":[54],"action":[55,125,193,248],"noted":[56],"in":[57,128,179,221,231],"HeLa":[58,197],"cervical":[59],"carcinoma":[60],"cells":[61,157,198],"under":[62],"doxorubicin":[63],"(DOX)":[64],"sulindac":[66],"(SUL)":[67],"co-treatment.":[68],"MATERIAL/METHODS:":[69],"Cytotoxic":[70],"defined":[76],"with":[77,83,99,234],"MTT":[78],"test,":[79,85],"apoptosis":[80,144],"detected":[82],"TUNEL":[84],"DOX":[86,127,153,171,195,226,247],"transmembrane":[87],"efflux":[88,154,224],"measured":[90],"fluorometrically,":[91],"expression":[92],"MDR-1":[94,184,214],"MRP-1":[96,216],"determined":[98],"quantitative":[100],"real":[101],"time":[102],"-":[103,162],"PCR":[104,163],"(QRT-PCR).":[105],"RESULTS:":[106],"It":[107,188],"SUL":[111,137,175,250],"at":[112],"non-toxic":[113,202],"concentrations,":[114],"10":[115],"50":[117,141,176],"microM,":[118,132],"is":[119,189,199,209],"an":[120],"enhancer":[122],"cytotoxic":[124,192],"for":[126,136,183],"0.5":[129],"1":[131,147,172],"respectively;":[133],"however,":[134],"only":[135],"concentration":[138],"equal":[139],"microM":[142,148,173,177],"potentiated":[143],"induced":[145],"by":[146,201,249],"DOX.":[150],"Moreover,":[151],"blocking":[152,222],"outside":[155,227],"observed.":[159],"QRT":[161],"analysis":[164],"has":[165],"that,":[167],"when":[168],"used":[169],"simultaneously,":[170],"results":[178,220,241],"decreased":[180],"mRNA":[181],"level":[182],"MRP-1.":[186],"CONCLUSIONS:":[187],"concluded":[190],"against":[196],"enhanced":[200,235],"concentrations":[203],"SUL.":[205],"observed":[207],"effect":[208],"due":[210],"quenching":[212],"genes":[217],"expression,":[218],"which":[219,230],"cells,":[229],"turn":[232],"correlates":[233],"apoptotic":[236],"effects.":[237],"According":[238],"obtained":[240],"potentiating":[245],"dose":[252],"specific.":[253]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
