{"id":"https://openalex.org/W2300957697","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.5072","title":"Biweekly schedule of pegylated liposomal doxorubicin (PLD) induces low rates of skin toxicities: Results of a phase-II trial in heavily preteated patients with relapsed ovarian cancer","display_name":"Biweekly schedule of pegylated liposomal doxorubicin (PLD) induces low rates of skin toxicities: Results of a phase-II trial in heavily preteated patients with relapsed ovarian cancer","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W2300957697","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.5072","mag":"2300957697"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.5072","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.5072","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.5072","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002555374","display_name":"Jalid Sehouli","orcid":"https://orcid.org/0000-0002-5963-6623","observed_orcids":["https://orcid.org/0000-0002-5963-6623"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Sehouli","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050727129","display_name":"G\u00fclten Oskay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Oskay","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014453044","display_name":"Ioanna Katsares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Katsares","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036531617","display_name":"Peter Klare","orcid":"https://orcid.org/0009-0003-1733-2634","observed_orcids":["https://orcid.org/0009-0003-1733-2634","https://orcid.org/0000-0002-3195-8620"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Klare","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110475680","display_name":"Hans-Joachim Hindenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. J. Hindenburg","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052269870","display_name":"G. Heinrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Heinrich","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060645594","display_name":"Barbara Schmalfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Schmalfeld","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035000215","display_name":"Dominique Koensgen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Koensgen","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059327156","display_name":"Werner Lichtenegger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. Lichtenegger","raw_affiliation_strings":["Charite, Med. University, Dept. of Gynecology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Med. University, Dept. of Gynecology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"5072","last_page":"5072"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegylated-liposomal-doxorubicin","display_name":"pegylated liposomal doxorubicin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/skin-toxicity","display_name":"skin toxicity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6069999933242798},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/heavily-pretreated-patients","display_name":"heavily pretreated patients","score":0.8240000009536743},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6639999747276306},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9036122560501099},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6350487470626831},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.595180332660675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5690576434135437},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47195544838905334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45526647567749023},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.44650861620903015},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4362528324127197},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4045239984989166},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3554973602294922}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.5072","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.5072","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.5072","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.5072","doi":"https://doi.org/10.1200/jco.2004.22.90140.5072","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.5072","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982763666","https://openalex.org/W2213445629","https://openalex.org/W2016078393","https://openalex.org/W2114461363","https://openalex.org/W2484491509","https://openalex.org/W4245323330","https://openalex.org/W1983790945","https://openalex.org/W2021898807","https://openalex.org/W2590556434","https://openalex.org/W2101094141"],"abstract_inverted_index":{"5072":[0],"Background:":[1],"Pegylated":[2],"liposomal":[3],"doxorubicin":[4],"(":[5],"PLD)":[6],"formulation":[7],"has":[8],"been":[9],"approved":[10],"for":[11],"the":[12,26,47,59,85,101,155,162,183,277,281,283,310],"treatment":[13,117,184,272],"of":[14,36,41,55,79,88,104,133,154,161,216,233,239,271,280,303],"recurrent":[15],"ovarian":[16],"cancer":[17],"(ROC).":[18],"Toxic":[19],"skin":[20,191,305],"reactions":[21],"were":[22,136,145,157,164,171,248],"reported":[23],"as":[24],"being":[25],"dose-limiting":[27],"toxicity":[28,48,102,220],"and":[29,120,174,202,237,252,295],"have":[30],"an":[31,293],"impact":[32],"on":[33],"patients'":[34],"quality":[35],"life":[37],"(QoL).":[38],"The":[39,307],"objective":[40,78],"this":[42,80,89,287],"study":[43,81,98],"was":[44,72,82,149,185,222,228],"to":[45,58,74,83,99,291,329],"optimize":[46],"profile":[49,103,221],"by":[50,250,316,321],"choosing":[51],"a":[52,95,214,258,264,300,317],"biweekly":[53],"schedule":[54,289,312],"PLD":[56,105],"according":[57],"experience":[60],"in":[61,108,158,165,172],"patients":[62,109],"with":[63,111,118,195,199,206],"AIDS-related":[64],"Kaposi":[65],"sarcoma.":[66],"A":[67,131],"specific":[68],"symptom":[69],"check":[70],"list":[71],"used":[73],"investigate":[75],"QoL.":[76],"Secondary":[77],"evaluate":[84],"response":[86,247],"rates":[87],"new":[90,288],"regimen.":[91],"Methods:":[92],"We":[93],"performed":[94],"multi-institutional":[96],"phase-II":[97],"analyze":[100],"(20mg/m2/q":[106],"14d)":[107],"(pts)":[110],"ROC.":[112],"Eligibility":[113],"criteria:":[114],"ROC,":[115],"prior":[116,180],"platinum-":[119],"paclitaxel,":[121],"ECOG":[122],"status":[123],"0\u20132,":[124],"organ":[125],"functioning":[126],"within":[127],"normal":[128],"range.":[129],"Results:":[130],"total":[132],"65":[134],"pts":[135,156,163,170,189,194,205,282],"recruited":[137],"(10/2001\u201311/2003).":[138],"419":[139],"courses":[140],"(median:":[141],"6,":[142],"range:":[143],"1\u201322)":[144],"evaluable.":[146],"Median":[147],"age":[148],"59":[150],"(35\u201380).":[151],"Only":[152,230],"12":[153],"second-line,":[159],"most":[160],"third-":[166],"or":[167],"fourth-line.":[168],"Nine":[169],"fifth-line":[173],"one":[175],"patient":[176,256],"had":[177],"6":[178,217],"different":[179],"regimens.":[181],"Overall,":[182],"well":[186,296],"tolerated.":[187],"24":[188,261],"developed":[190,257,263],"toxicities:":[192],"15":[193],"grade":[196,200,207,226,235,240],"I,":[197],"5":[198],"II":[201],"only":[203],"4":[204],"III.":[208],"These":[209],"side":[210],"effects":[211],"occurred":[212,242],"after":[213,267],"median":[215],"courses.":[218],"Heamatologic":[219],"favourable:":[223],"no":[224],"thrombocytopenia":[225],"III/IV":[227],"observed.":[229],"3.2%":[231],"episodes":[232],"lymphocytopenia":[234],"III":[236],"0.7%":[238],"IV":[241],"without":[243],"clinical":[244],"sequelae.":[245],"Clinical":[246],"evaluable":[249],"CA-125-monitoring":[251],"radiologic":[253],"measurements.":[254],"One":[255],"partial":[259],"response,":[260],"ts":[262],"progressive":[265],"disease":[266],"seven":[268],"cycles":[269],"(median)":[270],"(range:":[273],"5\u201318).":[274],"Conclusions:":[275],"Despite":[276],"heavily":[278],"pretreatment":[279],"results":[284],"suggest":[285],"that":[286],"seems":[290],"be":[292,314],"effective":[294],"tolerated":[297],"regimen,":[298],"showing":[299],"low":[301],"incidence":[302],"toxic":[304],"reactions.":[306],"superiority":[308],"over":[309],"conventional":[311],"must":[313],"clarified":[315],"randomised":[318],"trial.":[319],"Supported":[320],"ESSEX":[322],"Pharma":[323],"Germany.":[324],"No":[325],"significant":[326],"financial":[327],"relationships":[328],"disclose.":[330]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
