{"id":"https://openalex.org/W2300907321","doi":"https://doi.org/10.1038/srep23110","title":"Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model","display_name":"Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model","publication_year":2016,"publication_date":"2016-03-15","ids":{"openalex":"https://openalex.org/W2300907321","doi":"https://doi.org/10.1038/srep23110","mag":"2300907321","pmid":"https://pubmed.ncbi.nlm.nih.gov/26976677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4791555"},"language":"en","primary_location":{"id":"doi:10.1038/srep23110","doi":"https://doi.org/10.1038/srep23110","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep23110","pdf_url":"https://www.nature.com/articles/srep23110.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2300907321"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep23110.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076146973","display_name":"Aeri Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Aeri Shim","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055075196","display_name":"Jae-Hyoung Song","orcid":"https://orcid.org/0000-0002-8150-6091","observed_orcids":["https://orcid.org/0000-0002-8150-6091"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Hyoung Song","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040832154","display_name":"Bo-Eun Kwon","orcid":"https://orcid.org/0000-0002-8748-1171","observed_orcids":["https://orcid.org/0000-0002-8748-1171"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bo-Eun Kwon","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100916018","display_name":"Jeong-Jun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong-Jun Lee","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103624414","display_name":"Jae-Hee Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Hee Ahn","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101466740","display_name":"Yeon\u2010Jeong Kim","orcid":"https://orcid.org/0000-0002-5159-828X","observed_orcids":["https://orcid.org/0000-0002-5159-828X"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon-Jeong Kim","raw_affiliation_strings":["College of Pharmacy, Inje University, Gimhae, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Inje University, Gimhae, South Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069913861","display_name":"Ki\u2010Jong Rhee","orcid":"https://orcid.org/0000-0001-5130-2728","observed_orcids":["https://orcid.org/0000-0001-5130-2728"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4405258769","display_name":"Yonsei University Mirae Campus","ror":"https://ror.org/0160gc229","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966","https://openalex.org/I4405258769"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Jong Rhee","raw_affiliation_strings":["Department of Biomedical Laboratory Science, Yonsei University, Wonju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Science, Yonsei University, Wonju, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4405258769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108572671","display_name":"Sun-Young Chang","orcid":"https://orcid.org/0000-0001-7336-9245","observed_orcids":["https://orcid.org/0000-0001-7336-9245","https://orcid.org/0000-0003-3775-9355"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun-Young Chang","raw_affiliation_strings":["College of Pharmacy, Ajou University, Suwon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ajou University, Suwon, South Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011031561","display_name":"Younggil Cha","orcid":"https://orcid.org/0000-0003-2671-9059","observed_orcids":["https://orcid.org/0000-0003-2671-9059"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Younggil Cha","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086997980","display_name":"Yong Soo Lee","orcid":"https://orcid.org/0000-0002-8550-1925","observed_orcids":["https://orcid.org/0000-0002-8550-1925"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Soo Lee","raw_affiliation_strings":["University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022739081","display_name":"Mi\u2010Na Kweon","orcid":"https://orcid.org/0000-0003-2916-2524","observed_orcids":["https://orcid.org/0000-0003-2916-2524"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi-Na Kweon","raw_affiliation_strings":["University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041188741","display_name":"Kwi Sung Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwi Sung Park","raw_affiliation_strings":["Chungcheongnam-do Institute of Health and Environmental Research, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chungcheongnam-do Institute of Health and Environmental Research, Daejeon, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652259","display_name":"Dong\u2010Eun Kim","orcid":"https://orcid.org/0000-0001-6545-8387","observed_orcids":["https://orcid.org/0000-0001-6545-8387"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Eun Kim","raw_affiliation_strings":["Incurable Diseases Therapeutics Research Center, Korea Research Institute of Bioscience &Biotechnology, Cheongju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Incurable Diseases Therapeutics Research Center, Korea Research Institute of Bioscience &Biotechnology, Cheongju, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058248427","display_name":"Sungchan Cho","orcid":"https://orcid.org/0000-0001-7627-978X","observed_orcids":["https://orcid.org/0000-0001-7627-978X"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungchan Cho","raw_affiliation_strings":["Incurable Diseases Therapeutics Research Center, Korea Research Institute of Bioscience &Biotechnology, Cheongju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Incurable Diseases Therapeutics Research Center, Korea Research Institute of Bioscience &Biotechnology, Cheongju, South Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086925583","display_name":"Hyun\u2010Jong Cho","orcid":"https://orcid.org/0000-0002-5070-9371","observed_orcids":["https://orcid.org/0000-0002-5070-9371"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Jong Cho","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021016946","display_name":"Hyun\u2010Jeong Ko","orcid":"https://orcid.org/0000-0002-3844-928X","observed_orcids":["https://orcid.org/0000-0002-3844-928X"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyun-Jeong Ko","raw_affiliation_strings":["College of Pharmacy, Kangwon National University, Chuncheon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Kangwon National University, Chuncheon, South Korea","institution_ids":["https://openalex.org/I165507594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5021016946"],"corresponding_institution_ids":["https://openalex.org/I165507594"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.2072,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9096625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"23110","last_page":"23110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9189000129699707,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human-rhinovirus","display_name":"human rhinovirus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/common-cold","display_name":"common cold","score":0.9290000200271606},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/nasal-spray","display_name":"nasal spray","score":0.906000018119812},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cholesterol-transport","display_name":"cholesterol transport","score":0.6370000243186951},{"id":"https://openalex.org/keywords/plasma-membrane-cholesterol","display_name":"plasma membrane cholesterol","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.8932753801345825},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.8676109313964844},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5599856972694397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4988746643066406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4350818991661072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33340126276016235},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3232121467590332},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.20825126767158508},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.1261853277683258}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010850","descriptor_name":"Picornaviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010850","descriptor_name":"Picornaviridae Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010850","descriptor_name":"Picornaviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/srep23110","doi":"https://doi.org/10.1038/srep23110","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep23110","pdf_url":"https://www.nature.com/articles/srep23110.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3762828","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4791555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26976677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26976677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4791555","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4791555/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/13193","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/srep23110","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/13884.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/13193","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1038/srep23110","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/13884.pdf","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/srep23110","doi":"https://doi.org/10.1038/srep23110","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep23110","pdf_url":"https://www.nature.com/articles/srep23110.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1378445631","display_name":null,"funder_award_id":"NRF-2014R1A2A2A01002576","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7289456946","display_name":null,"funder_award_id":"NRF-2014R1A1A2003820","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2300907321.pdf","grobid_xml":"https://content.openalex.org/works/W2300907321.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1968937930","https://openalex.org/W1971219620","https://openalex.org/W1980260667","https://openalex.org/W1988212011","https://openalex.org/W1998429300","https://openalex.org/W2007736853","https://openalex.org/W2011564077","https://openalex.org/W2022959960","https://openalex.org/W2027541119","https://openalex.org/W2029442766","https://openalex.org/W2034780639","https://openalex.org/W2036586511","https://openalex.org/W2042679507","https://openalex.org/W2045213815","https://openalex.org/W2048629875","https://openalex.org/W2053796616","https://openalex.org/W2057434635","https://openalex.org/W2059340661","https://openalex.org/W2065220920","https://openalex.org/W2070762099","https://openalex.org/W2076053525","https://openalex.org/W2076309204","https://openalex.org/W2078796151","https://openalex.org/W2083626146","https://openalex.org/W2095394002","https://openalex.org/W2106284392","https://openalex.org/W2107533173","https://openalex.org/W2109280266","https://openalex.org/W2112956661","https://openalex.org/W2130226958","https://openalex.org/W2132065245","https://openalex.org/W2133570598","https://openalex.org/W2133646471","https://openalex.org/W2135561166","https://openalex.org/W2143414844","https://openalex.org/W2153022420","https://openalex.org/W2154525100","https://openalex.org/W2166567139","https://openalex.org/W2167386045","https://openalex.org/W2169303799","https://openalex.org/W2171584951","https://openalex.org/W2373128289","https://openalex.org/W4211018774"],"related_works":["https://openalex.org/W2157546837","https://openalex.org/W2137273860","https://openalex.org/W2114626540","https://openalex.org/W2909643250","https://openalex.org/W4404105040","https://openalex.org/W2554502224","https://openalex.org/W1157736039","https://openalex.org/W7033365414","https://openalex.org/W2040248326","https://openalex.org/W2087449721"],"abstract_inverted_index":{"Human":[0],"rhinovirus":[1],"(HRV)":[2],"is":[3,13,22,169],"the":[4,14,18,58,121,135,148,162,175],"most":[5],"common":[6,19],"viral":[7],"infectious":[8],"agent":[9,173],"in":[10,57,78,97,120,134,155,158],"humans":[11],"and":[12,74,94],"predominant":[15],"cause":[16],"of":[17,50,60,69,102,116,123,177],"cold.":[20],"There":[21],"a":[23,124,170],"need":[24],"for":[25,174],"appropriate":[26],"vaccines":[27],"or":[28],"therapeutic":[29],"agents":[30],"to":[31,64,90,147],"treat":[32],"HRV":[33,141,178],"infection.":[34,113],"In":[35],"this":[36],"study,":[37],"we":[38],"investigated":[39],"whether":[40],"itraconazole":[41],"(ICZ)":[42],"can":[43,181],"protect":[44],"cells":[45],"from":[46],"HRV-induced":[47],"cytotoxicity.":[48],"Replication":[49],"HRV1B":[51,87,112],"was":[52,138],"reduced":[53,77],"by":[54,83,111],"ICZ":[55,84,107,119,143,168],"treatment":[56,176],"lungs":[59],"HRV1B-":[61],"as":[62,151,153,185,187],"compared":[63],"vehicle-treated":[65],"mice.":[66],"The":[67],"numbers":[68],"immune":[70],"cells,":[71],"including":[72],"granulocytes":[73],"monocytes,":[75],"were":[76],"bronchoalveolar":[79],"lavage":[80],"fluid":[81],"(BALF)":[82],"administration":[85],"after":[86],"infection,":[88,179],"corresponding":[89],"decreased":[91],"pro-inflammatory":[92],"cytokine":[93],"chemokine":[95],"levels":[96],"BALF.":[98],"A":[99],"histological":[100],"analysis":[101],"lung":[103],"tissue":[104],"showed":[105],"that":[106,167],"suppressed":[108],"inflammation":[109],"caused":[110],"Interestingly,":[114],"pretreatment":[115],"mice":[117],"with":[118],"form":[122],"nasal":[125],"spray":[126],"had":[127],"potent":[128],"prophylactic":[129],"antiviral":[130,172],"activity.":[131],"Cholesterol":[132],"accumulation":[133,157],"plasma":[136,149],"membrane":[137],"observed":[139],"upon":[140],"infection;":[142],"blocked":[144],"cholesterol":[145],"trafficking":[146],"membrane,":[150],"well":[152,186],"resulted":[154],"its":[156],"subcellular":[159],"compartments":[160],"near":[161],"nucleus.":[163],"These":[164],"findings":[165],"suggest":[166],"potential":[171],"which":[180],"be":[182],"adopted":[183],"preventatively":[184],"therapeutically.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}