{"id":"https://openalex.org/W2300829928","doi":null,"title":"ANTIHYPERGLYCEMIC, ANTIOXIDANT, AND PANCREAS REGENERATION ACTIVITIES OF BLACK CUMIN (NIGELLA SATIVA L.) SEEDS ETHANOL EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS","display_name":"ANTIHYPERGLYCEMIC, ANTIOXIDANT, AND PANCREAS REGENERATION ACTIVITIES OF BLACK CUMIN (NIGELLA SATIVA L.) SEEDS ETHANOL EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS","publication_year":2016,"publication_date":"2016-03-15","ids":{"openalex":"https://openalex.org/W2300829928","mag":"2300829928"},"language":"en","primary_location":{"id":"mag:2300829928","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/9859","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/9859","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109451451","display_name":"Gunawan Pamudji Widodo","orcid":"https://orcid.org/0009-0004-6423-7979","observed_orcids":["https://orcid.org/0009-0004-6423-7979"]},"institutions":[{"id":"https://openalex.org/I4210130532","display_name":"Universitas Setia Budi","ror":"https://ror.org/03gn53446","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210130532"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Gunawan Pamudji Widodo","raw_affiliation_strings":["Faculty of Pharmacy, Setia Budi University, Jalan Letjen Sutoyo Mojosongo, Surakarta,  Indonesia, 57127"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Setia Budi University, Jalan Letjen Sutoyo Mojosongo, Surakarta,  Indonesia, 57127","institution_ids":["https://openalex.org/I4210130532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012706562","display_name":"Rina Herowati","orcid":"https://orcid.org/0009-0004-6423-7979","observed_orcids":["https://orcid.org/0009-0004-6423-7979","https://orcid.org/0000-0001-5497-6701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rina Herowati","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-6423-7979","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030097623","display_name":"Jason Merari Peranginangin","orcid":"https://orcid.org/0009-0001-6962-4490","observed_orcids":["https://orcid.org/0009-0001-6962-4490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Merari Peranginangin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063670129","display_name":"Jefri Edison Yuliaser Kamlasi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jefri Edison Yuliaser Kamlasi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4074,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83248295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"8","issue":"5","first_page":"37","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nigella-sativa","display_name":"Nigella sativa","score":0.9850000143051147},{"id":"https://openalex.org/keywords/black-cumin-seed-extract","display_name":"black cumin seed extract","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.7599999904632568},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pancreatic-regeneration","display_name":"pancreatic regeneration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.628000020980835},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":1.0},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.7670000195503235},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.865667998790741},{"id":"https://openalex.org/C2993714443","wikidata":"https://www.wikidata.org/wiki/Q160575","display_name":"Nigella sativa","level":2,"score":0.8416707515716553},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7681088447570801},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.5835487246513367},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5821688771247864},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5383279323577881},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5281111001968384},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5102329254150391},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5101392865180969},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.48435553908348083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37942442297935486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.369530588388443},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.32879412174224854},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24274799227714539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20781368017196655},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14474555850028992}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2300829928","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/9859","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"mag:2300829928","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/9859","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1975980695","https://openalex.org/W2017794275","https://openalex.org/W2025655168","https://openalex.org/W2028283287","https://openalex.org/W2029132541","https://openalex.org/W2033118457","https://openalex.org/W2035069368","https://openalex.org/W2047626527","https://openalex.org/W2099805775","https://openalex.org/W2127232154","https://openalex.org/W2157745394","https://openalex.org/W2167543749","https://openalex.org/W2286882947","https://openalex.org/W3148954841"],"related_works":["https://openalex.org/W3016086082","https://openalex.org/W4319215481","https://openalex.org/W2331075337","https://openalex.org/W3010569691","https://openalex.org/W2208192937","https://openalex.org/W6930329622","https://openalex.org/W1151277467","https://openalex.org/W7222961534","https://openalex.org/W2291300620","https://openalex.org/W2742334792"],"abstract_inverted_index":{"Objective":[0],":":[1,38,131,223],"The":[4,41,119],"goal":[5],"of":[6,21,24,50,69,91,107,115,136,152,164,180,191,201,212,216,233],"this":[7],"study":[8,106],"was":[9,61,81,86,110],"to":[10],"determine":[11],"the":[12,67,89,108,113,116,144,178,197,210],"antihyperglycemic,":[13],"antioxidant":[14,84,150,242],"as":[15,17,96,98,174,176,244,246],"well":[16,97,175,245],"pancreas":[18,109,198,247],"regeneration":[19,199,248,271],"effects":[20],"ethanol":[22],"extracts":[23],"Nigella":[26,262],"sativa":[27,57,139,159,204,228,263],"L.":[29,265],"seeds":[30,59,141,161,206,230],"in":[31,101,155],"alloxan-induced":[32,254],"diabetic":[33,153,255],"rats.":[34],"Methods":[37],"male":[42],"Wistar":[43],"rats":[44],"were":[45,122],"induced":[46],"by":[47,88,124],"intraperitoneal":[48],"injection":[49],"alloxan":[51],"(150":[52],"mg/kg":[53,73,166,237],"bw).":[54],"N.":[56,138,158,203,227],"extract":[60,142,162,231],"prepared":[62],"and":[63,71,83,104,148,171,183,214,235],"orally":[64],"administrated":[65],"at":[66,112],"dose":[68,163,190,232],"125":[70,192,234],"250":[72,165,236],"bw":[74],"for":[75],"28":[76],"d.":[77],"Blood":[78],"glucose":[79,145,169],"level":[80],"measured,":[82],"status":[85,151],"determined":[87],"activities":[90],"superoxide":[92,181],"dismutase,":[93],"glutathione":[94,184],"peroxidase":[95],"malonyl":[99,172],"aldehyde":[100],"liver.":[102,156],"Histopathological":[103],"immunohistochemistry":[105],"conducted":[111],"end":[114],"experimental":[117],"period.":[118],"data":[120],"obtained":[121],"analyzed":[123],"one-way":[125],"ANOVA":[126],"(p<0.05).":[127],"Results":[130],"Both":[134],"doses":[135],"showed":[143,238],"lowering":[146],"effect":[147],"corrected":[149],"animals":[154],"decreased":[167],"blood":[168],"levels":[170],"aldehyde,":[173],"increased":[177],"activity":[179,200],"dismutase":[182],"peroxidase,":[185],"more":[186],"effective":[187],"than":[188],"a":[189],"mg/kg.":[193],"Immunohistopathology":[194],"profiles":[195],"proved":[196],"extract,":[207,267],"based":[208],"on":[209,252],"enhanced":[211,241],"diameter":[213],"amount":[215],"Langerhans":[217],"islet":[218],"cells.":[219],"Conclusion":[222],"antihyperglycemic":[239],"effect,":[240],"activity,":[243],"from":[249],"organ":[250],"damage":[251],"an":[253],"rat.":[256],"Keywords:":[259],"seed":[266],"Antihyperglycemic,":[268],"Antioxidant,":[269],"Pancreas":[270]},"counts_by_year":[{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
