{"id":"https://openalex.org/W2300733419","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5017","title":"Clinical characteristics and outcomes of BRCA-associated ovarian cancer (OC): Genotype and survival.","display_name":"Clinical characteristics and outcomes of BRCA-associated ovarian cancer (OC): Genotype and survival.","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2300733419","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5017","mag":"2300733419"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.5017","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5017","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.5017","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084929109","display_name":"Verena Engelstaedter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"V. Engelstaedter","raw_affiliation_strings":["Department of Medical Oncology, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","University Hospital of Ludwig-Maximilians-University, Department of Obstetrics and Gynecology, Campus Innenstadt, Maistrasse 11, 80337 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"University Hospital of Ludwig-Maximilians-University, Department of Obstetrics and Gynecology, Campus Innenstadt, Maistrasse 11, 80337 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046159625","display_name":"Mihaela C. Cristea","orcid":"https://orcid.org/0000-0003-2580-530X","observed_orcids":["https://orcid.org/0000-0003-2580-530X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. C. Cristea","raw_affiliation_strings":["CITY OF HOPE NATIONAL MEDICAL CENTER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CITY OF HOPE NATIONAL MEDICAL CENTER","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005206482","display_name":"Judy Ellen Garber","orcid":"https://orcid.org/0000-0001-9449-3982","observed_orcids":["https://orcid.org/0000-0001-9449-3982"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. E. Garber","raw_affiliation_strings":["CITY OF HOPE NATIONAL MEDICAL CENTER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CITY OF HOPE NATIONAL MEDICAL CENTER","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062123247","display_name":"Susan L. Neuhausen","orcid":"https://orcid.org/0000-0001-5053-0390","observed_orcids":["https://orcid.org/0000-0001-5053-0390"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. L. Neuhausen","raw_affiliation_strings":["Department of Population Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010","Division of Information Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA 91010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]},{"raw_affiliation_string":"Division of Information Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082853715","display_name":"Paul Henry Frankel","orcid":"https://orcid.org/0000-0003-2231-6121","observed_orcids":["https://orcid.org/0000-0003-2231-6121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. H. Frankel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011225415","display_name":"Sharon R. Sand","orcid":"https://orcid.org/0000-0002-9390-5583","observed_orcids":["https://orcid.org/0000-0002-9390-5583"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"S. Sand","raw_affiliation_strings":["Department of Medical Oncology, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","University Hospital of Ludwig-Maximilians-University, Department of Obstetrics and Gynecology, Campus Innenstadt, Maistrasse 11, 80337 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"raw_affiliation_string":"University Hospital of Ludwig-Maximilians-University, Department of Obstetrics and Gynecology, Campus Innenstadt, Maistrasse 11, 80337 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Steele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Steele","raw_affiliation_strings":["Department of Population Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Sciences, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058249824","display_name":"Ursula A. Matulonis","orcid":"https://orcid.org/0000-0002-3103-6992","observed_orcids":["https://orcid.org/0000-0002-3103-6992"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210110999","display_name":"CancerCare","ror":"https://ror.org/01xjn4f21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U. Matulonis","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber/Partners CancerCare, 450 Brookline Avenue, Boston, MA 02215-5450","Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber/Partners CancerCare, 450 Brookline Avenue, Boston, MA 02215-5450","institution_ids":["https://openalex.org/I4210110999"]},{"raw_affiliation_string":"Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060953135","display_name":"Joyce F. Liu","orcid":"https://orcid.org/0000-0003-3888-3972","observed_orcids":["https://orcid.org/0000-0003-3888-3972"]},"institutions":[{"id":"https://openalex.org/I4210110999","display_name":"CancerCare","ror":"https://ror.org/01xjn4f21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Liu","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber/Partners CancerCare, 450 Brookline Avenue, Boston, MA 02215-5450"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber/Partners CancerCare, 450 Brookline Avenue, Boston, MA 02215-5450","institution_ids":["https://openalex.org/I4210110999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029960276","display_name":"Jeffrey N. Weitzel","orcid":"https://orcid.org/0000-0001-6714-092X","observed_orcids":["https://orcid.org/0000-0001-6714-092X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Weitzel","raw_affiliation_strings":["CITY OF HOPE NATIONAL MEDICAL CENTER"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CITY OF HOPE NATIONAL MEDICAL CENTER","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"5017","last_page":"5017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hereditary-ovarian-cancer","display_name":"hereditary ovarian cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7089999914169312},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.4880000054836273},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.8199999928474426},{"id":"https://openalex.org/keywords/germline-mutation-carriers","display_name":"germline mutation carriers","score":0.6179999709129333},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8872808218002319},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6438330411911011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6421142816543579},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5701770782470703},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5533959269523621},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5248258709907532},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5184309482574463},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47335052490234375},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.46965184807777405},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4577663242816925},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.45006999373435974},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.44307416677474976},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4132727086544037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14619293808937073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09548404812812805},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.5017","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5017","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.5017","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3355877513","display_name":null,"funder_award_id":"RC4-CA153828","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7378251461","display_name":"Clinical Cancer Genetics Community Network: A Sustainable Research Partnership","funder_award_id":"1rc4ca153828-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G926788725","display_name":"Genetic Epidemiology of Breast Cancer: BRCA1 and BRCA2","funder_award_id":"R01CA074415","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1523531555","https://openalex.org/W1571406835","https://openalex.org/W1826136795","https://openalex.org/W1927868261","https://openalex.org/W1992015449","https://openalex.org/W1999659306","https://openalex.org/W2000197817","https://openalex.org/W2007576032","https://openalex.org/W2009740718","https://openalex.org/W2025460005","https://openalex.org/W2036687174","https://openalex.org/W2059000312","https://openalex.org/W2064083593","https://openalex.org/W2065849886","https://openalex.org/W2067117419","https://openalex.org/W2073025417","https://openalex.org/W2073931597","https://openalex.org/W2077419786","https://openalex.org/W2091961739","https://openalex.org/W2100525241","https://openalex.org/W2110017381","https://openalex.org/W2110790489","https://openalex.org/W2114787582","https://openalex.org/W2114860131","https://openalex.org/W2124322375","https://openalex.org/W2135340562","https://openalex.org/W2142397500","https://openalex.org/W2142795777","https://openalex.org/W2142871091","https://openalex.org/W2143934748","https://openalex.org/W2150111967","https://openalex.org/W2156077962","https://openalex.org/W2157899948","https://openalex.org/W2162110703","https://openalex.org/W2171972386","https://openalex.org/W2208114517","https://openalex.org/W2216554257","https://openalex.org/W2276971282","https://openalex.org/W2329417450","https://openalex.org/W2329931367","https://openalex.org/W2335272574","https://openalex.org/W3093265161","https://openalex.org/W4249199995"],"related_works":["https://openalex.org/W2089617691","https://openalex.org/W2330623959","https://openalex.org/W2102004732","https://openalex.org/W1845943907","https://openalex.org/W1894955529","https://openalex.org/W2077419786","https://openalex.org/W2533216796","https://openalex.org/W2599721525","https://openalex.org/W2329931367","https://openalex.org/W2397436984"],"abstract_inverted_index":{"5017":[0],"Background:":[1],"Mutations":[2],"in":[3,12,106,129,170,191,315],"BRCA1":[4,123,182,241],"and":[5,49,56,63,81,86,118,155,183,206,219],"BRCA2,":[6],"tumor-suppressor":[7],"genes":[8],"with":[9,18,31,72,166,173,245,253,275,283,303],"distinct":[10],"roles":[11],"homologous":[13],"recombination":[14],"repair,":[15],"are":[16],"associated":[17,252,302],"an":[19,34],"increased":[20],"risk":[21,227,257],"of":[22,51,67,70,93,104,228,258,291,325],"OC.":[23,40,74],"Prior":[24],"studies":[25,43,109],"have":[26,33,44,278],"suggested":[27],"that":[28,298],"BRCA":[29,82],"carriers":[30,222],"OC":[32,52,98,277,293],"improved":[35],"survival":[36,50,120,280,305],"compared":[37,60,239],"to":[38,240,295,335],"sporadic":[39,284],"However,":[41,195],"few":[42],"examined":[45,128],"whether":[46],"clinical":[47,61],"features":[48,62],"differs":[53],"between":[54,313],"BRCA1-":[55],"BRCA2-deficient":[57],"tumors.":[58],"We":[59],"outcome":[64],"by":[65],"genotype":[66,83],"a":[68,144,224,254,322],"cohort":[69],"women":[71,274],"BRCA-associated":[73,97,276,292],"Methods:":[75],"Clinical":[76,114],"data,":[77],"including":[78,318],"age,":[79],"stage,":[80,220],"were":[84,127,135],"obtained":[85],"treatment":[87],"history":[88],"abstracted":[89],"from":[90],"chart":[91],"review":[92,103],"patient":[94],"records":[95],"for":[96,122,181,186,204,211,217,270],"cases":[99,134,294],"identified":[100,136],"through":[101],"retrospective":[102],"participants":[105],"IRB-approved":[107],"registry":[108],"at":[110,197],"3":[111],"cancer":[112],"centers.":[113],"characteristics,":[115],"event-free":[116],"(EFS)":[117],"overall":[119],"(OS)":[121],"vs.":[124,149,161],"BRCA2":[125,141,205,221,250,299],"mutation":[126],"multivariate":[130,214],"analyses.":[131],"Results:":[132],"164":[133],"(119":[137],"BRCA1;":[138],"45":[139],"BRCA2).":[140,187],"patients":[142,244],"had":[143,223],"higher":[145],"mean":[146],"age":[147,218],"(56.7":[148],"52.2":[150],"years;":[151],"p":[152,163,236,266],"<":[153,164,267],"0.01),":[154],"fewer":[156],"poorly":[157],"differentiated":[158],"tumors":[159],"(69%":[160],"87%;":[162],"0.02),":[165],"no":[167],"significant":[168,189,332],"difference":[169,190],"the":[171,288],"proportion":[172],"advanced":[174,246],"stage":[175,247],"(3":[176],"or":[177,321],"4)":[178],"(85/118":[179],"[72%]":[180],"31/45":[184],"[69%]":[185],"No":[188,331],"EFS":[192],"was":[193,199,251],"observed.":[194],"OS":[196],"5-years":[198],"73%":[200],"(95%":[201,208],"CI":[202,209,234,264],"60-89)":[203],"63%":[207],"54-73)":[210],"BRCA1.":[212,307],"In":[213,243],"analysis,":[215],"adjusting":[216],"nonsignificant":[225],"reduced":[226,256],"death":[229,259],"(HR":[230,260],"=":[231,237,261],"0.6,":[232],"95%":[233,263],"0.31-1.14,":[235],"0.12)":[238],"carriers.":[242],"(>":[248],"3A),":[249],"significantly":[255],"0.45,":[262],"0.21-0.98,":[265],"0.05,":[268],"adjusted":[269],"age).":[271],"Conclusions:":[272],"While":[273],"better":[279,304],"than":[281,306],"those":[282],"disease,":[285],"this":[286],"is":[287],"largest":[289],"set":[290],"date":[296],"indicating":[297],"may":[300,309],"be":[301],"This":[308],"reflect":[310],"important":[311],"differences":[312],"genotypes":[314],"tumor":[316],"characteristics":[317],"chemotherapy":[319],"sensitivity,":[320],"greater":[323],"tendency":[324],"particular":[326],"mutations":[327],"towards":[328],"developing":[329],"platinum-resistance.":[330],"financial":[333],"relationships":[334],"disclose.":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}