{"id":"https://openalex.org/W2300630602","doi":"https://doi.org/10.1016/j.adaj.2015.12.008","title":"Double-masked, randomized, placebo-controlled study to evaluate the efficacy and tolerability of intranasal K305 (3% tetracaine plus 0.05% oxymetazoline) in anesthetizing maxillary teeth","display_name":"Double-masked, randomized, placebo-controlled study to evaluate the efficacy and tolerability of intranasal K305 (3% tetracaine plus 0.05% oxymetazoline) in anesthetizing maxillary teeth","publication_year":2016,"publication_date":"2016-01-25","ids":{"openalex":"https://openalex.org/W2300630602","doi":"https://doi.org/10.1016/j.adaj.2015.12.008","mag":"2300630602","pmid":"https://pubmed.ncbi.nlm.nih.gov/26822100"},"language":"en","primary_location":{"id":"doi:10.1016/j.adaj.2015.12.008","doi":"https://doi.org/10.1016/j.adaj.2015.12.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.adaj.2015.12.008","pdf_url":null,"source":{"id":"https://openalex.org/S116566766","display_name":"The Journal of the American Dental Association","issn_l":"0002-8177","issn":["0002-8177","1943-4723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the American Dental Association","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027904460","display_name":"Elliot V. Hersh","orcid":"https://orcid.org/0000-0002-3191-1371","observed_orcids":["https://orcid.org/0000-0002-3191-1371"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elliot V. Hersh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595261","display_name":"Andr\u00e9s Pinto","orcid":"https://orcid.org/0000-0003-2101-8886","observed_orcids":["https://orcid.org/0000-0003-2101-8886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andres Pinto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089993592","display_name":"Mana Saraghi","orcid":"https://orcid.org/0000-0001-9742-9951","observed_orcids":["https://orcid.org/0000-0001-9742-9951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mana Saraghi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111583385","display_name":"Najeed Saleh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Najeed Saleh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054949655","display_name":"Lisbeth Pulaski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisbeth Pulaski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108499503","display_name":"Sharon M. Gordon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon M. Gordon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110324818","display_name":"DOUGLAS M. BARNES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Barnes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029928496","display_name":"Gary Kaplowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Kaplowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ira Bloom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ira Bloom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028074598","display_name":"Mohammad Y. Sabti","orcid":"https://orcid.org/0000-0003-1598-1318","observed_orcids":["https://orcid.org/0000-0003-1598-1318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Sabti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023294934","display_name":"Paul A. Moore","orcid":"https://orcid.org/0000-0001-6057-7539","observed_orcids":["https://orcid.org/0000-0001-6057-7539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul A. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027743532","display_name":"Sean J. Lee","orcid":"https://orcid.org/0000-0001-6355-7277","observed_orcids":["https://orcid.org/0000-0001-6355-7277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260919","display_name":"Michael Meharry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Meharry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103404557","display_name":"David Y. He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Y. He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100346312","display_name":"Yiming Li","orcid":"https://orcid.org/0000-0001-6361-6900","observed_orcids":["https://orcid.org/0000-0001-6361-6900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiming Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027904460"],"corresponding_institution_ids":[],"apc_list":{"value":3850,"currency":"USD","value_usd":3850},"apc_paid":null,"fwci":4.4,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93413602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"147","issue":"4","first_page":"278","last_page":"287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12145","display_name":"Dental Anxiety and Anesthesia Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12145","display_name":"Dental Anxiety and Anesthesia Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracaine","display_name":"tetracaine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oxymetazoline","display_name":"oxymetazoline","score":1.0},{"id":"https://openalex.org/keywords/nasal-spray","display_name":"nasal spray","score":0.6589999794960022},{"id":"https://openalex.org/keywords/maxillary-teeth","display_name":"maxillary teeth","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dental-restorative-procedures","display_name":"dental restorative procedures","score":0.7200000286102295},{"id":"https://openalex.org/keywords/rhinorrhea","display_name":"rhinorrhea","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nasal-congestion","display_name":"nasal congestion","score":0.9769999980926514},{"id":"https://openalex.org/keywords/articaine","display_name":"articaine","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8746936321258545},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7438346147537231},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6860255002975464},{"id":"https://openalex.org/C2778455913","wikidata":"https://www.wikidata.org/wiki/Q419608","display_name":"Tetracaine","level":3,"score":0.6394524574279785},{"id":"https://openalex.org/C2780973058","wikidata":"https://www.wikidata.org/wiki/Q1755275","display_name":"Nasal spray","level":3,"score":0.6148771643638611},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5962685346603394},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5761423707008362},{"id":"https://openalex.org/C2780042274","wikidata":"https://www.wikidata.org/wiki/Q417813","display_name":"Oxymetazoline","level":4,"score":0.5693962574005127},{"id":"https://openalex.org/C2778994108","wikidata":"https://www.wikidata.org/wiki/Q1868462","display_name":"Local anesthetic","level":2,"score":0.5086565613746643},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.47729408740997314},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47327184677124023},{"id":"https://openalex.org/C2779699568","wikidata":"https://www.wikidata.org/wiki/Q1115038","display_name":"rhinorrhea","level":2,"score":0.4633837938308716},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.4566257894039154},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.4427779018878937},{"id":"https://openalex.org/C2779789940","wikidata":"https://www.wikidata.org/wiki/Q858590","display_name":"Nostril","level":3,"score":0.4346037805080414},{"id":"https://openalex.org/C2910477827","wikidata":"https://www.wikidata.org/wiki/Q430719","display_name":"Nasal decongestant","level":2,"score":0.42544251680374146},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.4219723343849182},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.3404190242290497},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3333205282688141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13033297657966614},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000766","descriptor_name":"Anesthesia, Dental","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000766","descriptor_name":"Anesthesia, Dental","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008437","descriptor_name":"Maxilla","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010109","descriptor_name":"Oxymetazoline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010109","descriptor_name":"Oxymetazoline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010109","descriptor_name":"Oxymetazoline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013748","descriptor_name":"Tetracaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013748","descriptor_name":"Tetracaine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013748","descriptor_name":"Tetracaine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014070","descriptor_name":"Tooth","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D014663","descriptor_name":"Nasal Decongestants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014663","descriptor_name":"Nasal Decongestants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014663","descriptor_name":"Nasal Decongestants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.adaj.2015.12.008","doi":"https://doi.org/10.1016/j.adaj.2015.12.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.adaj.2015.12.008","pdf_url":null,"source":{"id":"https://openalex.org/S116566766","display_name":"The Journal of the American Dental Association","issn_l":"0002-8177","issn":["0002-8177","1943-4723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the American Dental Association","raw_type":"journal-article"},{"id":"pmid:26822100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26822100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Dental Association (1939)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9868999719619751,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W51673791","https://openalex.org/W159671445","https://openalex.org/W168743389","https://openalex.org/W204301463","https://openalex.org/W1741464604","https://openalex.org/W1858706367","https://openalex.org/W1974147917","https://openalex.org/W1975031152","https://openalex.org/W1983609729","https://openalex.org/W1987271774","https://openalex.org/W1990936416","https://openalex.org/W1993300471","https://openalex.org/W2046202850","https://openalex.org/W2054371641","https://openalex.org/W2059850345","https://openalex.org/W2071681089","https://openalex.org/W2100723302","https://openalex.org/W2122624477","https://openalex.org/W2145093466","https://openalex.org/W2332864795","https://openalex.org/W6777380772","https://openalex.org/W6876762876"],"related_works":["https://openalex.org/W2269521124","https://openalex.org/W2522412914","https://openalex.org/W2917252128","https://openalex.org/W2145093466","https://openalex.org/W175749483","https://openalex.org/W2735563228","https://openalex.org/W3045135138","https://openalex.org/W3132160956","https://openalex.org/W2998379269","https://openalex.org/W6986411908"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}